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SEMI-SYNTHETIC ANTIBODIES AS RECOGNITION ELEMENTS

  • US 20110229415A1
  • Filed: 08/06/2008
  • Published: 09/22/2011
  • Est. Priority Date: 08/06/2007
  • Status: Abandoned Application
First Claim
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1. A biosensor for detecting a molecule of interest, comprising:

  • (a) a probe, including a purine molecule and a fluorophore bound to the purine molecule; and

    (b) an antibody, including an antigen-binding site that selectively binds the molecule of interest and a purine-binding site, wherein the probe is covalently bound at the purine molecule to the purine-binding site,wherein binding of the molecule of interest to the antibody causes a conformational change in the antibody, which detectably alters a fluorescence intensity of the fluorophore such that the molecule of interest can be detected.

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