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METHODS OF ASSAYING URINARY NEUTROPHIL GELATINASE-ASSOCIATED LIPOCALIN (uNGAL) IN THE PROGNOSIS OF CADAVERIC KIDNEY TRANSPLANT FUNCTION IN A PATIENT, INCLUDING A PATIENT DIAGNOSED WITH DELAYED GRAFT FUNCTION (DGF), A METHOD OF ASSAYING uNGAL IN THE ASSESSMENT OF RISK OF DGF IN A PATIENT DIAGNOSED WITH EARLY GRAFT FUNCTION (EGF), AND RELATED KITS

  • US 20110229921A1
  • Filed: 06/09/2010
  • Published: 09/22/2011
  • Est. Priority Date: 03/18/2010
  • Status: Abandoned Application
First Claim
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1. A method of prognosticating cadaveric kidney transplant function in a patient, which method comprises:

  • assaying urine samples from the patient for urinary neutrophil gelatinase-associated lipocalin (uNGAL) to allow detection of a change in the level of uNGAL in a urine sample from the patient at about 24 hours after cadaveric kidney transplantation in comparison to the level of uNGAL in a urine sample from the patient at within about 24 hours before cadaveric kidney transplantation, wherein assaying comprises detecting the level of uNGAL in the urine sample, wherein;

    detecting a decrease in the level of uNGAL of less than or equal to about 55% in the level of uNGAL in a urine sample from the patient at about 24 hours after cadaveric kidney transplantation in comparison to the level of uNGAL in a urine sample from the patient at within about 24 hours before cadaveric kidney transplantation predicts delayed graft function (DGF), whereas detecting a decrease in the level of uNGAL of greater than about 55% in a urine sample from the patient at about 24 hours after cadaveric kidney transplantation in comparison to the level of uNGAL in a urine sample from the patient at within about 24 hours before cadaveric kidney transplantation predicts early graft function (EGF),whereupon cadaveric kidney transplant function in a patient is prognosticated.

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