OPHTHALMIC SOLUTIONS, INCLUDING CONTACT LENS CARE AND EYE DROPS COMPRISING CARNOSINE, PREFERABLY IN COMBINATION WITH DEXPANTHENOL AND/OR HYALURONIC ACID

• US 20110230424A1
• Filed: 11/17/2009
• Published: 09/22/2011
• Est. Priority Date: 11/17/2008
• Status: Abandoned Application

• Current Assignee: Louis Johan Wagenaar
• Original Assignee: Louis Johan Wagenaar
• Inventors: Wagenaar, Louis Johan
• Application Number:
  US13/129,709
• Publication Number:
  US 20110230424A1
• Time in Patent Office: Days
• US Class Current: 514/20.8
• CPC Class Codes: A61K 2300/00 Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
• CPC Class Codes: A61K 31/164 of a carboxylic acid with an aminoalcohol, e.g. ceramides
• CPC Class Codes: A61K 31/198 Alpha-amino acids, e.g. alanine or edetic acid [EDTA] betaine A61K31/205; proline A61K31/401; tryptophan A61K31/405; histidine A61K31/4172; peptides not degraded to individual amino acids A61K38/00
• CPC Class Codes: A61K 31/4172 Imidazole-alkanecarboxylic acids, e.g. histidine
• CPC Class Codes: A61K 31/728 Hyaluronic acid
• CPC Class Codes: A61L 12/141 Biguanides, e.g. chlorhexidine
• CPC Class Codes: A61L 12/142 Polymeric biguanides
• CPC Class Codes: A61L 12/145 Polymeric quaternary ammonium compounds
• CPC Class Codes: A61P 27/02 Ophthalmic agents
• CPC Class Codes: C11D 3/0078 Compositions for cleaning contact lenses, spectacles or lenses
• CPC Class Codes: C11D 3/222 Natural or synthetic polysaccharides, e.g. cellulose, starch, gum, alginic acid or cyclodextrin
• CPC Class Codes: C11D 3/33 Amino carboxylic acids
• CPC Class Codes: C11D 3/48 Medical, disinfecting agents, disinfecting, antibacterial, germicidal or antimicrobial compositions
• CPC Class Codes: C11D 7/3245 Aminoacids

Abstract

The current invention relates to a contact lens care solution comprising a compound suitable for treating the eye, or the contact lens, use of such compound in such contact lens care solutions, and methods for introducing such compound in the eye of a person wearing contact lenses. With the current invention damage to the eye, in particular the cornea, in particular damage to the eye, in particular the cornea, of a person wearing a contact lens, or as a consequence of wearing a contact lens is prevented or reduced./esp.

Claims

1. Ophthalmic composition comprising carnosine preferably said ophthalmic composition further comprises a compound selected from the group consisting of dexpanthenol and hyaluronic acid, even more preferably said composition comprises carnosine, dexpanthenol and hyaluronic acid.

2. Ophthalmic composition according to claim 1, wherein said ophthalmic solution is a contact lens care solution or an eye drop, preferably a contact lens care solution.

3. Ophthalmic composition according to claim 1, wherein said ophthalmic composition is a contact lens care solution, and wherein said contact lens care solution comprises (% by weight)

4. Contact lens care solution according to claim 2 wherein the composition comprises (% by weight)

5. Eye drop according to claim 2 comprising (in weight %, based on the total eye drop composition):

carnosine;

0.05-10 weight %, preferably 0.1-5 weight %, even more preferably 0.5-4 weight %; and

dexpanthenol;

0.05-10 weight %, preferably 0.1-4 weight %, even more preferably 0.5-2 weight %; and

, optionally

hyaluronic acid;

0.001-0.4%, preferably 0.005-0.2, even more preferably 0.005-0.1%.

6. Ophthalmic composition, preferably a contact lens care solution, according to claim 1 further comprising a disinfectant, preferably selected from the group consisting of biguanides, biguanide polymers, salts thereof, N-alkyl-2-pyrrolidone, polyquaternium-1, bronopol and hydrogen peroxide, hexamethylene biguanide polymer (PHMB).

7. Ophthalmic composition, preferably a contact lens care solution, according to claim 1 wherein the composition further comprises ophthalmically acceptable surface active ingredient(s), preservatives, germicides, disinfectants, salts and/or buffers.

17. Method for preparing a contact lens comprising carnosine, carnosine and hyaluronic acid, preferably carnosine and dexpanthenol or even more preferably carnosine, dexpanthenol and hyaluronic acid characterized in that the method comprises the steps of incubating a contact lens with carnosine, carnosine and hyaluronic acid, preferably carnosine and dexpanthenol or even more preferably carnosine, dexpanthenol and hyaluronic acid, preferably the carnosine, preferably carnosine and dexpanthenol or even more preferably carnosine, dexpanthenol and hyaluronic acid is provided in the form of a contact lens care solution as defined in claim 1.

18. A method for the administration of carnosine, carnosine and hyaluronic acid, preferably carnosine and dexpanthenol or even more preferably carnosine, dexpanthenol and hyaluronic acid to the eye of a person wearing a contact lens, wherein the administration comprises, at least once,

a) incubation of a contact lens in a contact lens care solution as defined in claim 1;

b) introducing said incubated lens in the eye of the person;

c) removing the contact lens from the eye of the person.

19. The method according to claim 18 wherein the administration further comprises after step c,

d) re-incubating the contact lens in a contact lens care solution as defined in claim 1;

e) re-introducing the contact lens in the eye of the person.

20. The method according to claim 18, wherein the contact lens is incubated in the contact lens care solution for a period of at least 1 hour, preferably at least 3 hours, more preferably at least 4 hours, most preferably at least 6 hours.

21. The method according to claim 18 wherein the contact lens is present in the eye of the person for a period of at least 1 hours, preferably at least 2 hours, preferably at least 4 hours, and preferably at least 16 hours.

8. In a method of treating the eye using an eye drop or of maintaining a contact lens using a contact lens care solution, the improvement wherein said eye drop or said contact lens care solution comprises carnosine, or carnosine and hyaluronic acid, preferably carnosine and dexpanthenol, even more preferably carnosine, dexpanthenol and hyaluronic acid.

9. The method according to claim 8 wherein the carnosine is not N-acetyl-carnosine.

10. The method according to claim 8 wherein carnosine is comprised in the contact lens care solution or eye drop in a concentration of between 0.01-5% by weight, preferably of between 0.1-2.5% by weight, more preferably of between 0.15-0.5% by weight.

11. The method according to claim 8 wherein the contact lens care solution is for reducing corneal staining, preferably for reducing corneal staining in the eye of a contact lens wearer.

12. The method according to claim 8, wherein the contact lens care solution further comprises a disinfectant.

13. The method according to claim 8 wherein the solution comprises ophthalmically acceptable surface active ingredient(s), disinfectants, preservatives, salts and buffers.

14. The method of a ophthalmic composition, preferably a contact lens care solution according to claim 8 for reducing corneal staining.

15. The method according to claim 8 wherein the use comprises treating a contact lens, preferably a day contact lens or a night contact lens, with the contact lens care solution.

16. A pharmaceutical composition comprising carnosine, preferably carnosine and a compound selected from the group consisting of dexpanthenol and hyaluronic acid (or acceptable salts thereof), preferably carnosine and dexpanthenol, even preferably carnosine, dexpanthenol and hyaluronic acid wherein the pharmaceutical composition is suitable for administration to the eye, preferably wherein the pharmaceutical composition is in the form of a contact lens care solution or an eye drop.