PERFLUOROCARBON EYE CREAM FORMULATIONS

• US 20110230566A1
• Filed: 03/18/2011
• Published: 09/22/2011
• Est. Priority Date: 03/19/2010
• Status: Abandoned Application

• Current Assignee: Tenax Therapeutics, Inc.
• Original Assignee: Tenax Therapeutics, Inc.
• Inventors: Kiral, Richard, Tamargo, Maria Isabel, Grossman, Aharon
• Application Number:
  US13/051,112
• Publication Number:
  US 20110230566A1
• Time in Patent Office: Days
• US Class Current: 514/759
• CPC Class Codes: A61K 8/315 Halogenated hydrocarbons
• CPC Class Codes: A61P 17/00 Drugs for dermatological disorders
• CPC Class Codes: A61Q 19/08 Anti-ageing preparations

Abstract

Disclosed are perfluorocarbon compositions for cosmetic applications, in particular, for application to the periocular skin, and methods for using the same.

Claims

1. A method of delivering oxygen to a periocular skin of a subject comprising topically administering to a facial area consisting of the periocular skin of the subject a composition comprising a perfluorocarbon effective to deliver oxygen to the periocular skin.

3. The method of claim 1, wherein the molecular formula of the perfluorocarbon consists fluorine atoms and 9-12 carbon atoms.

4. The method of claim 3, wherein the perfluorocarbon is perfluoro(tert-butylcyclohexane).

5. The method of claim 1, wherein the composition is in the form of a cream.

6. The method of claim 1, wherein the composition is administered periodically.

7. The method of claim 6, wherein the composition is administered twice daily.

8. The method of claim 6, wherein the administration is for a period of greater than 3 weeks.

9. The method of claims 8, wherein the administration is for a period of 8 weeks or more.

10. The method of any one of claim 1, wherein the subject'"'"'s Fitzpatrick Wrinkle Assessment Scale score is decreased.

11. The method of claim 10, wherein the subject'"'"'s Fitzpatrick Wrinkle Assessment Scale score is decreased by at least 1 point.

12. The method of claim 10, wherein the subject'"'"'s Fitzpatrick Wrinkle Assessment Scale score is decreased by at least 2 points.

13. The method of claim 1, wherein the subject'"'"'s Global Aesthetic Improvement Scale score is improved.

14. The method of claim 1, wherein the improvement in appearance is the reduction of the severity of fine lines, wrinkles, skin elastosis, puffiness, dark circles, under-eye circles, bags and/or dark blemishes.

33. The method of claim 1, comprising topically administering to the subject the perfluorocarbon cream composition of claim 15.

2. A method of improving the appearance of a periocular skin of a subject comprising topically administering to a facial area consisting of the periocular skin of the subject a composition comprising a perfluorocarbon effective to improve the appearance of the periocular skin.

15. A perfluorocarbon cream composition comprising 1) a perfluorocarbon, 2) ascorbyl glucoside, 3) a first mixture comprising butylene glycol, water, niacinamide, Fraxinus excelsior bark extract, silanetriol, and potassium citrate, 4) a second mixture comprising water, glycerin, steareth-20, N-hydroxysuccinimide, chrysin, palmitoyl oligopeptide and palmitoyl tetrapeptide-7 and 5) a third mixture comprising glycerin, water, butylene glycol, carbomer, polysorbate 20, palmitoyl oligopeptide, and palmitoyl tetrapeptide-7.

34. The method of claim 2, comprising topically administering to the subject the perfluorocarbon cream composition of claim 15.

16-32. -32. (canceled)