SYSTEM AND APPARATUS FOR THE NON-INVASIVE MEASUREMENT OF GLUCOSE LEVELS IN BLOOD
First Claim
1. Apparatus for a non-invasive measurement of glucose levels in blood of a patient, comprising:
- an autoregressive mobile average type (ARMA) pre-processing system element to pre-process an input signal;
a stochastic model system element that provides a model of an autoregressive mobile average type (ARMA) blood pressure pulse on a Teager-Kaiser operator of an input signal;
clinical data of a patient, including one or more of sex, age, height, and body mass index and its functions; and
a function estimation system based on random forests.
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Abstract
A system for estimating the glucose levels in blood is developed in the present invention. Said system establishes a physiological model of the pulse wave and its energy, which are also correlated with the glucose metabolic function, for generating a fixed length vector containing the values of the previous model combined with other variables related to the user such as, for example, age, sex, height, weight, etc. . . . This fixed length vector is used as an excitation of a function estimation system based on “random forests” for the calculation of the interest variable. The main advantage of this parameter estimation system lays in the fact that it does not apply any restriction a priori on the function to be estimated, and that it is robust in front of heterogeneous data, such as in the case of the present invention.
49 Citations
43 Claims
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1. Apparatus for a non-invasive measurement of glucose levels in blood of a patient, comprising:
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an autoregressive mobile average type (ARMA) pre-processing system element to pre-process an input signal; a stochastic model system element that provides a model of an autoregressive mobile average type (ARMA) blood pressure pulse on a Teager-Kaiser operator of an input signal; clinical data of a patient, including one or more of sex, age, height, and body mass index and its functions; and a function estimation system based on random forests. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13)
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14. A computer-implemented, non-invasive method of measuring a glucose level of a patient, comprising:
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receiving clinical parameters of the patient; receiving an electronic photoplethysmography (PPG) signal captured from a measurement location of the patient; extracting measurement parameters from the electronic PPG signal; identifying, by a processor, a fixed length vector based on the clinical parameters and the measurement parameters; performing, by a processor, a function estimation using the fixed length vector as a seed vector; and outputting the result of the function estimation as a glucose level. - View Dependent Claims (15, 16, 17, 18, 19, 20, 21, 22, 23)
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24. A computer readable storage medium having instructions stored thereon that, when executed by a processor, cause the processor to execute a method comprising:
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receiving clinical parameters of the patient; receiving a photoplethysmography (PPG) signal captured from a measurement location of the patient; extracting measurement parameters from the PPG signals; identifying a fixed length vector based on the clinical parameters and the measurement parameters; performing a function estimation using the fixed length vector as a seed vector; and outputting the result of the function estimation as an estimated glucose level. - View Dependent Claims (25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43)
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Specification