IMPLANTABLE BIOMEDICAL DEVICES ON BIORESORBABLE SUBSTRATES

• US 20110230747A1
• Filed: 09/28/2010
• Published: 09/22/2011
• Est. Priority Date: 03/17/2010
• Status: Active Grant

• Current Assignee: Northwestern University, Trustees of Tufts College, Trustees Of The University Of Pennsylvania (University of Pennsylvania)
• Original Assignee: Trustees of Tufts College
• Inventors: KAPLAN, David, VIVENTI, Jonathan, KIM, Dae-Hyeong, OMENETTO, Fiorenzo, LITT, Brian, HUANG, Yonggang, ROGERS, John A.
• Granted Patent: US 8,666,471 B2
• Time in Patent Office: Days
• US Class Current: 600/377
• CPC Class Codes: A61B 2562/0285 Nanoscale sensors
• CPC Class Codes: A61B 5/05 Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fields; Measuring using microwaves or radio waves impedance plethysmography A61B5/0295; measuring movement of the entire body or parts thereof A61B5/11; detecting, measuring or recording bioelectric or biomagnetic signals of the body or parts thereof A61B5/24
• CPC Class Codes: A61B 5/24 Detecting, measuring or recording bioelectric or biomagnetic signals of the body or parts thereof
• CPC Class Codes: A61B 5/6867 specially adapted to be attached or implanted in a specific body part A61B5/6847 takes precedence
• CPC Class Codes: A61L 31/047 Other specific proteins or polypeptides not covered by A61L31/044 - A61L31/046
• CPC Class Codes: A61L 31/148 Materials at least partially resorbable by the body
• CPC Class Codes: A61N 1/0529 Electrodes for brain stimulation
• CPC Class Codes: A61N 1/0551 Spinal or peripheral nerve electrodes
• CPC Class Codes: B82Y 15/00 Nanotechnology for interacting, sensing or actuating, e.g. quantum dots as markers in protein assays or molecular motors
• CPC Class Codes: H01L 2924/00 Indexing scheme for arrangements or methods for connecting or disconnecting semiconductor or solid-state bodies as covered by H01L24/00
• CPC Class Codes: H01L 2924/0002 Not covered by any one of groups H01L24/00, H01L24/00 and H01L2224/00
• CPC Class Codes: H05K 1/0283 Stretchable printed circuits
• CPC Class Codes: H05K 3/20 by affixing prefabricated conductor pattern H05K1/187, H05K3/046, H05K3/4658, H05K3/4682 takes precedence

Abstract

Provided herein are implantable biomedical devices and methods of administering implantable biomedical devices, making implantable biomedical devices, and using implantable biomedical devices to actuate a target tissue or sense a parameter associated with the target tissue in a biological environment.

Claims

1. An implantable biomedical device for actuating a target tissue or sensing a parameter associated with the target tissue in a biological environment, said device comprising:

a bioresorbable substrate;

an electronic device comprising a plurality of inorganic semiconductor components supported by said bioresorbable substrate, wherein at least one of said inorganic semiconductor components has at least one physical dimension less than or equal to 100 microns; and

a barrier layer encapsulating at least a portion of said inorganic semiconductor components,

wherein upon contact with said biological environment said bioresorbable substrate is at least partially resorbed, thereby establishing conformal contact between said implantable biomedical device and said target tissue in said biological environment.

2. The device of claim 1 further comprising a biocompatible layer provided on said bioresorbable substrate, wherein the biocompatible layer is position between the electronic device and the bioresorbable substrate.

3. The device of claim 1, wherein said biological environment is an in-vivo biological environment.

4. The device of claim 1, wherein said target tissue in said biological environment comprises heart tissue, brain tissue, muscle tissue, epithelial tissue, nerve tissue, or vascular tissue.

5. The device of claim 1, wherein said bioresorbable substrate is completely resorbed upon contact with said biological environment.

6. The device of claim 1, wherein said bioresorbable substrate is not completely resorbed upon contact with said biological environment.

7. The device of claim 1, wherein resorption of said bioresorbable substrate establishes conformal contact, physical contact, or electrical contact between said electronic device and said target tissue.

8. The device of claim 1, wherein resorption of said bioresorbable substrate provides the electronic device in optical communication with said target tissue.

9. The device of claim 1, wherein said bioresorbable substrate comprises a biopolymer, a synthetic polymer, a protein, a polysaccharide, silk or any combination of these.

10. The device of claim 1, wherein said bioresorbable substrate comprises a poly(glycerol-sebacate) (PGS), polydioxanone, poly(lactic-co-glycolic acid) (PLGA), polylactic acid (PLA), collagen, chitosan, fibroin, silkworm fibroin, modified silkworm fibroin, spider silk, insect silk, recombinant silk, or any combination of these.

11. The device of claim 1, wherein said bioresorbable substrate has a thickness selected from the range of 100 nanometers to 10000 μ

m.

12. The device of claim 1, wherein said bioresorbable substrate has a Young'"'"'s modulus selected from the range of 0.5 MPa and 10 GPa.

13. The device of claim 1, wherein said bioresorbable substrate has a net bending stiffness selected from the range of 0.1×

10⁴ GPa μ

m⁴ and 1×

10⁹ GPa μ

m⁴.

14. The device of claim 1, wherein the bioresorbable substrate has a degree of crystallinity selected over the range of 0 to 55%.

15. The device of claim 1, wherein said implantable biomedical device has a neutral mechanical plane and at least a portion of said plurality of inorganic semiconductor components is positioned proximate to said neutral mechanical plane.

16. The device of claim 1, wherein at least one of said inorganic semiconductor components is a flexible semiconductor structure or a stretchable semiconductor structure.

17. The device of claim 1, wherein at least one of said inorganic semiconductor components is a nanoribbon, a nanomembrane, a nanowire, a transistor channel, a diode, a p-n junction, a photodiode, a light emitting diode, a laser or a combination of these.

18. The device of claim 1, wherein at least one of said inorganic semiconductor components of the electronic device has a thickness less than or equal to 10 microns.

19. The device of claim 1, wherein at least one of said inorganic semiconductor components of the electronic device has a thickness selected from the range of 50 nanometers to 10 microns.

20. The device of claim 1, wherein at least one of said inorganic semiconductor components of the electronic device has a Young'"'"'s modulus selected from the range of 0.5 MPa to 10 GPa.

21. The device of claim 1, wherein at least one of said inorganic semiconductor components of the electronic device has a net bending stiffness less than or equal to 1×

10⁸ GPa μ

m⁴.

22. The device of claim 1, wherein at least one of said inorganic semiconductor components comprises a single crystal inorganic semiconductor material.

23. The device of claim 1, wherein said electronic device comprises a plurality of island and bridge structures, wherein said island structures comprise one or more semiconductor circuit components of said electronic device, and wherein said bridge structures comprise one or more flexible electrical interconnects.

24. The device of claim 1, wherein said barrier layer comprises material selected from the group consisting of a polymer, an organic polymer, SU-8, an insulator, a polyimide, a dielectric, an inorganic dielectric, Si₃N₄, and any combination of these.

25. The device of claim 1, wherein said barrier layer has a thickness selected from the range of 1 μ

m to 100 μ

m.

26. The device of claim 1, wherein said bioresorbable substrate, said electronic device, and said barrier layer provide a net bending stiffness of the implantable biomedical device of less than 1×

10⁹ GPa μ

m⁴.

27. The device of claim 1, wherein said barrier layer has a mesh structure.

28. A method for administering an implantable biomedical device, said method comprising:

providing the implantable biomedical device comprising;

a bioresorbable substrate;

an electronic device comprising a plurality of inorganic semiconductor components supported by said bioresorbable substrate, wherein at least one of said inorganic semiconductor components has at least one physical dimension less than or equal to 100 microns; and

a barrier layer encapsulating at least a portion of said inorganic semiconductor components;

contacting said implantable biomedical device with a target tissue in a biological environment; and

at least partially resorbing said bioresorbable substrate in said biological environment, thereby establishing conformal contact between said implantable biomedical device and said target tissue in said biological environment.

29. The method of claim 28, wherein the Young'"'"'s modulus of said implantable biomedical device decreases by at least 50% upon resorption of the bioresorbable substrate.

30. The method of claim 28, wherein the net bending stiffness of said implantable biomedical device decreases by at least 50% upon resorption of the bioresorbable substrate.

31. A method of actuating a target tissue or sensing a parameter associated with the target tissue in a biological environment, said method comprising:

providing an implantable biomedical device comprising;

a bioresorbable substrate;

an electronic device comprising a plurality of inorganic semiconductor components supported by said bioresorbable substrate, wherein at least one of said inorganic semiconductor components has at least one physical dimension less than or equal to 100 microns; and

a barrier layer encapsulating at least a portion of said inorganic semiconductor components;

contacting said implantable biomedical device with the target tissue in a biological environment;

at least partially resorbing said bioresorbable substrate in said biological environment, thereby establishing conformal contact between said implantable biomedical device and said target tissue in said biological environment; and

actuating the target tissue or sensing the parameter associated with the target tissue that is in conformal contact with the implantable biomedical device.

32. The method of claim 31, wherein resorption of said bioresorbable substrate establishes physical contact, conformal contact, or electrical contact between said electronic device and said target tissue.

33. The method of claim 31, wherein said step of sensing the parameter associated with the target tissue that is in conformal contact with the implantable biomedical device comprises measuring voltage at a surface of the target tissue, measuring electromagnetic radiation at a surface of the target tissue or measuring a current at a surface of the target tissue.

34. The method of claim 31, wherein said step of actuating the target tissue that is in conformal contact with the implantable biomedical device comprises generating a voltage at a surface of the target tissue, generating electromagnetic radiation at a surface of the target tissue or generating a current at a surface of the target tissue.

35. An implantable biomedical device for actuating a target tissue or sensing a parameter associated with the target tissue in a biological environment, said device comprising:

an electrode array comprising a plurality of individually addressable metal electrodes, wherein each metal electrode has at least one physical dimension less than or equal to 100 microns;

a barrier layer having a mesh structure, wherein said barrier layer at least partially supports said electrode array; and

a bioresorbable substrate supporting said electrode array, said barrier layer or both of said electrode array and said barrier layer;

wherein upon contact with said biological environment said bioresorbable substrate is at least partially resorbed, thereby establishing conformal contact between said electrode array and said target tissue in said biological environment.

36. The device of claim 35, wherein said electrodes of said electrode array are physically separated from each other.

37. The device of claim 35, wherein said barrier layer is in physical contact with at least a portion of said electrodes of said electrode array or wherein said bioresorbable substrate is in physical contact with at least a portion of said electrode array or in physical contact with at least a portion of said barrier layer.

38. The device of claim 35, wherein each of said electrodes of said array is in electrical contact with at least one electronic interconnect.

39. The device of claim 35, wherein said bioresorbable substrate comprises a poly(glycerol-sebacate) (PGS), polydioxanone, poly(lactic-co-glycolic acid) (PLGA), polylactic acid (PLA), collagen, chitosan, fibroin, or any combination of these.

40. The device of claim 35, wherein said bioresorbable substrate comprises a silkworm fibroin, spider silk, insect silk, recombinant silk, or any combination of these.

41. The device of claim 35, wherein said bioresorbable substrate has a thickness selected from the range of 100 nanometers to 10000 μ

m.

42. The device of claim 35, wherein resorption of said bioresorbable substrate establishes physical contact, conformal contact, or electrical contact between said electrode array and said target tissue.

43. The device of claim 35, wherein said mesh structure is a perforated mesh structure or a tentacle mesh structure.

44. The device of claim 35, wherein said electrode array comprises 10 to 1000 electrodes.

45. The device of claim 35, wherein each of said metal electrodes has a thickness selected over the range of 100 nanometers to 10 microns.

46. The device of claim 35, wherein said metal electrodes comprise a bioinert metal or a biocompatible metal.

47. The device of claim 35, wherein said barrier layer has a thickness selected from the range of 1 μ

m to 100 μ

m.

48. A method for actuating a target tissue or sensing a parameter associated with the target tissue in a biological environment, the method comprising:

providing an implantable biomedical device comprising;

an electrode array comprising a plurality of individually addressable metal electrodes, wherein each metal electrode has at least one physical dimension less than or equal to 100 microns;

a barrier layer having a mesh structure, wherein said barrier layer at least partially supports said electrode array; and

a bioresorbable substrate supporting said electrode array, said barrier layer or both of said electrode array and said barrier layer;

contacting said implantable biomedical device with the target tissue in a biological environment;

wherein upon contact with said biological environment said bioresorbable substrate is at least partially resorbed, thereby establishing conformal contact between said electrode array and said target tissue in said biological environment; and

actuating the target tissue or sensing the parameter associated with the target tissue that is in conformal contact with the implantable biomedical device.

49. The method of claim 48, wherein said biological environment is an in-vivo biological environment.

50. The method of claim 48, wherein resorption of said bioresorbable substrate establishes physical contact, conformal contact, or electrical contact between said electronic device and said target tissue.

51. The method of claim 48, wherein said step of sensing the parameter associated with the target tissue that is in conformal contact with the implantable biomedical device comprises measuring voltage at a surface of the target tissue, measuring electromagnetic radiation at a surface of the target tissue or measuring a current at a surface of the target tissue.

52. The method of claim 48, wherein said step of actuating the target tissue that is in conformal contact with the implantable biomedical device comprises generating a voltage at a surface of the target tissue, generating electromagnetic radiation at a surface of the target tissue or generating a current at a surface of the target tissue.