SYSTEM AND METHOD FOR TREATING A THERAPEUTIC SITE

• US 20110230763A1
• Filed: 05/27/2011
• Published: 09/22/2011
• Est. Priority Date: 10/20/2005
• Status: Abandoned Application

• Current Assignee: Otsuka Medical Devices Co., Ltd. (Otsuka Holdings Company Limited)
• Original Assignee: Kona Medical, Inc.
• Inventors: Zhang, Jimin, Perozek, David M., Lahman, Robyn, Augustine, Larry, Emery, Charles
• Application Number:
  US13/118,144
• Publication Number:
  US 20110230763A1
• Time in Patent Office: Days
• US Class Current: 600/439
• CPC Class Codes: A61B 17/0057 Implements for plugging an opening in the wall of a hollow or tubular organ, e.g. for sealing a vessel puncture or closing a cardiac septal defect sutures A61B17/04; closing rectum or urethra near body surface A61F2/0009
• CPC Class Codes: A61B 18/02 by cooling, e.g. cryogenic techniques devices for cooling specific reflex points of the body within cell-life limits A61H39/06
• CPC Class Codes: A61B 2017/00557 inflatable A61B2017/22051 takes precedence
• CPC Class Codes: A61B 2017/00637 for sealing trocar wounds through abdominal wall
• CPC Class Codes: A61B 2017/00641 for closing fistulae, e.g. anorectal fistulae
• CPC Class Codes: A61B 2090/372 Details of monitor hardware
• CPC Class Codes: A61B 2090/3784 both receiver and transmitter being in the instrument or receiver being also transmitter
• CPC Class Codes: A61B 2090/3929 Active markers
• CPC Class Codes: A61B 2090/3958 emitting a signal
• CPC Class Codes: A61B 2090/397 electromagnetic other than visible, e.g. microwave
• CPC Class Codes: A61B 34/25 User interfaces for surgical systems
• CPC Class Codes: A61B 5/026 Measuring blood flow A61B3/1233, A61B3/1241 take precedence
• CPC Class Codes: A61B 50/13 Trolleys, e.g. carts
• CPC Class Codes: A61B 8/0833 involving detecting or locating foreign bodies or organic structures
• CPC Class Codes: A61B 8/0841 for locating instruments
• CPC Class Codes: A61B 8/12 in body cavities or body tracts, e.g. by using catheters catheters per se A61M25/00
• CPC Class Codes: A61B 8/4405 Device being mounted on a trolley
• CPC Class Codes: A61B 8/445 Details of catheter construction
• CPC Class Codes: A61F 2/82 Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents stent-grafts for tubular structures of the body other than blood vessels A61F2/04; stent-grafts for blood vessels A61F2/07; instruments specially adapted for placement or removal of stents or stent-grafts A61F2/95; for closing wounds, or holding wounds closed A61B17/04 - A61B17/115; dilators A61M29/00
• CPC Class Codes: A61M 25/10 Balloon catheters A61M25/0125 takes precedence; embolectomy A61B17/22032; retractors A61B17/02; inflatable balloons for placing stents or stent-grafts A61F2/958 ; stomach balloons for treatment of obesity A61F5/0003; oesophagal tubes A61J15/00
• CPC Class Codes: A61N 7/02 : Localised ultrasound hyperthermia hyperthermia in general A61F7/00

Abstract

A targeting catheter is used to locate an arteriotomy, such as is formed during a femoral artery catheterization procedure. The targeting catheter includes one or more targeting aids, such as an inflatable balloon or sensor (e.g., Doppler or temperature sensor), to locate the arteriotomy. The targeting aid may be positioned at the arteriotomy. An ultrasonic beacon on the catheter may then be located relative to a therapeutic ultrasonic applicator (e.g., by using acoustic time-of-flight) so that the focus of ultrasonic energy from the applicator can be aligned with the arteriotomy.

Claims

1. A system for delivering focused ultrasound to a therapeutic site adjacent a blood vessel, the system comprising:

an imaging transducer;

a plurality of receivers configured to receive one or more signals; and

at least one annular therapeutic transducer disposed proximate the imaging transducer and the plurality of receivers, wherein a focus of the at least one therapeutic transducer is adjusted based at least in part on the one or more signals received by the plurality of receivers.

2. The system of claim 1, wherein the imaging transducer comprises a Doppler transducer.

3. The system of claim 1, wherein each of the plurality of receivers comprises an acoustic time of flight receiver.

4. The system of claim 3, wherein each of the receivers is configured to receive one or more signals from a piezoelectric beacon configured to emit a sonic signal.

5. The system of claim 3, wherein each of the receivers is configured to receive one or more electromagnetic signals.

6. The system of claim 1, further comprising a targeting catheter having a locating beacon.

7. The system of claim 6, wherein each of the plurality of receivers is configured to receive one or more signals from the locating beacon.

8. The system of claim 7, wherein each of the plurality of receivers is configured to receive one or more signals from the locating beacon at least when the locating beacon is disposed within a blood vessel and when the receivers are disposed outside of the blood vessel.

9. A method of detecting tissue movement relative to an ultrasound applicator, the method comprising:

emitting a first set of ultrasonic pulses from one or more ultrasonic transducers, wherein the one or more ultrasonic transducers are located outside of a patient, and wherein the first set of pulses are directed towards a therapeutic site in tissue disposed inside the patient;

detecting a first set of ultrasonic echoes with the one or more ultrasonic transducers;

emitting a second set of ultrasonic pulses from the one or more ultrasonic transducers, wherein the one or more ultrasonic transducers are located outside of the patient, and wherein the second set of pulses are directed towards the therapeutic site;

detecting a second set of ultrasonic echoes with the one or more ultrasonic transducers;

comparing the first and second ultrasonic echoes; and

determining an amount of relative tissue movement based at least in part on the comparison and directional vectors between the one or more ultrasonic transducers and the therapeutic site; and

adjusting a focus of the ultrasound applicator based at least in part on the determined amount of relative tissue movement; and

emitting a dose of therapeutic ultrasonic energy from the ultrasound applicator.

10. The method of claim 9, wherein an intravascular catheter is disposed within a blood vessel.

11. A method of determining a location of a therapeutic site adjacent a blood vessel in a body relative to a therapeutic applicator, the method comprising:

inserting a targeting catheter into the body;

identifying the location of the therapeutic site using the targeting catheter; and

determining a position of the targeting catheter relative to the therapeutic applicator.

12. The method of claim 11, further comprising aligning the targeting catheter with the therapeutic applicator.

13. The method of claim 11, wherein the determining step utilizes triangulation.

14. The method of claim 11, wherein the targeting catheter comprises a transmitter.

15. The method of claim 14, wherein the transmitter comprises a piezoelectric emitter.

16. The method of claim 14, wherein the therapeutic applicator comprises a plurality of receivers configured to receive one or more signals emitted from the targeting catheter.

17. The method of claim 16, wherein the plurality of receivers are disposed about the at least one transducer.

18. The method of claim 11, wherein the targeting catheter comprises a receiver.

19. The method of claim 11, further comprising adjusting a focus of the therapeutic applicator based at least in part on the determined position of the targeting catheter.

20. The method of claim 19, further comprising emitting a dose of therapy from the therapeutic applicator such that the therapeutic site is exposed to the dose.

21. The method of claim 11, wherein the therapeutic applicator comprises at least one annular transducer.