SYSTEM AND METHOD FOR TREATING A THERAPEUTIC SITE

• US 20110230796A1
• Filed: 05/27/2011
• Published: 09/22/2011
• Est. Priority Date: 10/20/2005
• Status: Abandoned Application

• Current Assignee: Otsuka Medical Devices Co., Ltd. (Otsuka Holdings Company Limited)
• Original Assignee: Kona Medical, Inc.
• Inventors: Lahman, Robyn, Augustine, Larry, Emery, Charles, Zhang, Jimin, Perozek, David M.
• Application Number:
  US13/118,245
• Publication Number:
  US 20110230796A1
• Time in Patent Office: Days
• US Class Current: 601/2
• CPC Class Codes: A61B 17/0057 Implements for plugging an opening in the wall of a hollow or tubular organ, e.g. for sealing a vessel puncture or closing a cardiac septal defect sutures A61B17/04; closing rectum or urethra near body surface A61F2/0009
• CPC Class Codes: A61B 18/02 by cooling, e.g. cryogenic techniques devices for cooling specific reflex points of the body within cell-life limits A61H39/06
• CPC Class Codes: A61B 2017/00557 inflatable A61B2017/22051 takes precedence
• CPC Class Codes: A61B 2017/00637 for sealing trocar wounds through abdominal wall
• CPC Class Codes: A61B 2017/00641 for closing fistulae, e.g. anorectal fistulae
• CPC Class Codes: A61B 2090/372 Details of monitor hardware
• CPC Class Codes: A61B 2090/3784 both receiver and transmitter being in the instrument or receiver being also transmitter
• CPC Class Codes: A61B 2090/3929 Active markers
• CPC Class Codes: A61B 2090/3958 emitting a signal
• CPC Class Codes: A61B 2090/397 electromagnetic other than visible, e.g. microwave
• CPC Class Codes: A61B 34/25 User interfaces for surgical systems
• CPC Class Codes: A61B 5/026 Measuring blood flow A61B3/1233, A61B3/1241 take precedence
• CPC Class Codes: A61B 50/13 Trolleys, e.g. carts
• CPC Class Codes: A61B 8/0833 involving detecting or locating foreign bodies or organic structures
• CPC Class Codes: A61B 8/0841 for locating instruments
• CPC Class Codes: A61B 8/12 in body cavities or body tracts, e.g. by using catheters catheters per se A61M25/00
• CPC Class Codes: A61B 8/4405 Device being mounted on a trolley
• CPC Class Codes: A61B 8/445 Details of catheter construction
• CPC Class Codes: A61F 2/82 Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents stent-grafts for tubular structures of the body other than blood vessels A61F2/04; stent-grafts for blood vessels A61F2/07; instruments specially adapted for placement or removal of stents or stent-grafts A61F2/95; for closing wounds, or holding wounds closed A61B17/04 - A61B17/115; dilators A61M29/00
• CPC Class Codes: A61M 25/10 Balloon catheters A61M25/0125 takes precedence; embolectomy A61B17/22032; retractors A61B17/02; inflatable balloons for placing stents or stent-grafts A61F2/958 ; stomach balloons for treatment of obesity A61F5/0003; oesophagal tubes A61J15/00
• CPC Class Codes: A61N 7/02 : Localised ultrasound hyperthermia hyperthermia in general A61F7/00

Abstract

A targeting catheter is used to locate an arteriotomy, such as is formed during a femoral artery catheterization procedure. The targeting catheter includes one or more targeting aids, such as an inflatable balloon or sensor (e.g., Doppler or temperature sensor), to locate the arteriotomy. The targeting aid may be positioned at the arteriotomy. An ultrasonic beacon on the catheter may then be located relative to a therapeutic ultrasonic applicator (e.g., by using acoustic time-of-flight) so that the focus of ultrasonic energy from the applicator can be aligned with the arteriotomy.

Claims

1. A method of treating a therapeutic site adjacent a blood vessel within a patient, comprising:

inserting a targeting catheter into a patient;

emitting at least one signal from the targeting catheter from within the patient;

determining a location of a portion of the targeting catheter relative to a therapeutic ultrasound applicator based at least in part on the at least one signal; and

adjusting a focus of the therapeutic ultrasound applicator based on the determined location of the portion of the targeting catheter.

2. The method of claim 1, further comprising emitting a dose of high intensity focused ultrasound from the therapeutic applicator to the determined location.

3. The method of claim 1, further comprising identifying a location of the therapeutic site using the targeting catheter.

4. The method of claim 3, further comprising positioning the targeting catheter proximate to the therapeutic site adjacent the blood vessel.

5. The method of claim 1, wherein determining the location of the portion of the targeting catheter relative to the therapeutic applicator comprises using triangulation of the at least one signal emitted from the targeting catheter.

6. The method of claim 5, wherein the triangulation is based on magnetic fields.

7. The method of claim 5, wherein the triangulation is based on acoustic signals.

8. The method of claim 5, wherein the triangulation is based on an acoustic time-of-flight determination.

9. The method of claim 1, wherein determining the location of the portion of the targeting catheter relative to the therapeutic applicator comprises determining an acoustic time-of-flight from the targeting catheter to the therapeutic applicator.

10. The method of claim 9, wherein the at least one signal is emitted from a beacon disposed on the targeting catheter.

11. The method of claim 10, wherein the at least one signal comprises a tone burst of sound.

12. The method of claim 11, wherein the therapeutic applicator comprises a plurality of receivers disposed about one or more therapeutic ultrasonic transducers and further comprising receiving the at least one signal by the plurality of receivers.

13. The method of claim 1, wherein the at least one signal is an ultrasound signal.

14. The method of claim 1, further comprising providing a user interface to assist a user in adjusting the focus of the therapeutic applicator.

15. The method of claim 14, further comprising displaying graphical elements on the user interface.

16. A method of treating a therapeutic site within a patient, comprising:

inserting a targeting catheter into a patient, the targeting catheter comprising a receiver;

emitting at least one signal from a therapeutic ultrasound applicator that is disposed external to the patient;

receiving the at least one signal with the receiver;

determining a location of a portion of the targeting catheter relative to a therapeutic applicator based at least in part on the at least one signal; and

adjusting a focus of the therapeutic ultrasound applicator based on the determined location of the portion of the targeting catheter.

17. The method of claim 16, further comprising emitting a dose of high intensity focused ultrasound from the therapeutic applicator to the determined location.

18. The method of claim 16, further comprising identifying a location of the therapeutic site using the targeting catheter.

19. The method of claim 18, further comprising positioning the targeting catheter proximate to the therapeutic site.

20. A system for treating a therapeutic site within a patient, the system comprising:

a targeting catheter configured to be positioned within the patient and comprising a beacon configured to emit at least one signal from within the patient; and

a therapeutic applicator comprising one or more therapeutic ultrasound transducers and a plurality of receivers disposed about the therapeutic ultrasound transducers, wherein the receivers are configured to receive the at least one signal, and wherein the therapeutic ultrasound transducers are configured to determine a location of the portion of the targeting catheter relative to the therapeutic applicator based at least in part on the received signals.

21. The system of claim 20, wherein the therapeutic applicator comprises at least three receivers.

22. The system of claim 20, wherein the beacon is configured to emit a tone burst of sound.