PATTERNED NEO-EPITHELIALIZATION DRESSINGS, SYSTEMS, AND METHODS

• US 20110230809A1
• Filed: 03/10/2011
• Published: 09/22/2011
• Est. Priority Date: 03/16/2010
• Status: Active Grant

• Current Assignee: KCI Licensing Incorporated (3M Company)
• Original Assignee: KCI Licensing Incorporated (3M Company)
• Inventors: Manwaring, Michael, Leung, Braden K.
• Granted Patent: US 9,358,158 B2
• Time in Patent Office: Days
• US Class Current: 602/43
• CPC Class Codes: A61F 13/00063 comprising medicaments or additives, e.g. odor control, PH control, debriding, antimicrobic drug delivery dressings A61K9/70; chemical aspect of the additives A61L15/00
• CPC Class Codes: A61F 13/01021 characterised by the structure of the dressing
• CPC Class Codes: A61F 13/05 specially adapted for use with sub-pressure or over-pressure therapy, wound drainage or wound irrigation, e.g. for use with negative-pressure wound therapy [NPWT]
• CPC Class Codes: A61F 2013/00089 Wound bandages A61F2013/00361 takes precedence;
• CPC Class Codes: A61M 1/915 Constructional details of the pressure distribution manifold
• CPC Class Codes: A61M 2210/04 Skin
• CPC Class Codes: A61P 17/02 for treating wounds, ulcers, burns, scars, keloids, or the like

Abstract

Systems, methods, and apparatuses are presented that involve forming patterns on neo-epithelium that allow increased functionality and may more nearly resemble the original epithelium. In one instance, a patterned neo-epithelium dressing for treating a tissue site having granulation tissue includes an interface member for placing proximate the granulation tissue and a plurality of three-dimensional features formed on a second, patient-facing side of the interface member. Other systems, methods, and apparatuses are disclosed.

Claims

1. A system for treating a tissue site having granulation tissue on a patient, the system comprising:

a patterned neo-epithelium dressing for disposing proximate to granulation tissue on the tissue site, wherein the patterned neo-epithelium dressing comprises;

an interface member having a first side and a second, patient-facing side for placing proximate the granulation tissue, and

a plurality of three-dimensional features formed on the second, patient-facing side of the interface member and comprising a pattern that mimics human skin;

a sealing member for placing over the patterned neo-epithelium dressing and the patient'"'"'s epidermis;

a reduced-pressure interface fluidly coupled to the sealing member;

a reduced-pressure source fluidly coupled to the reduced-pressure interface; and

wherein the three-dimensional features are adapted to promote epithelium growth with a pattern analogous to human skin.

2. The system of claim 1, wherein the interface member is formed with a fluid passageway that fluidly couples the first side and the second, patient-facing side.

5. The system of claim 1, the interface member has a plurality of pores having an average pore size larger than 5 μ

m and smaller than 1000 μ

m.

8. The system of claim 1, wherein the plurality of three-dimensional features comprises an intact analogous human skin pattern.

9. The system of claim 1, wherein the plurality of three-dimensional features comprises a location-specific human skin pattern.

10. The system of claim 1, wherein the interface member comprises a medical-grade polymer.

13. The system of claim 1, wherein the interface member comprises a polyurethane film bonded to a foam.

14. The system of claim 1, wherein the interface member comprises a foam having rigid portions and less rigid portions, wherein, under reduced pressure, the less rigid portions compress more than the more rigid portions.

15. The system of claim 1, further comprising a protein coated on the plurality of three-dimensional features.

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20. A patterned neo-epithelium dressing for treating a tissue site having granulation tissue, the patterned neo-epithelium dressing comprising:

an interface member having a first side and a second, patient-facing side for placing proximate to the granulation tissue; and

a plurality of three-dimensional features formed on the second, patient-facing side of the interface member and comprising a pattern that mimics human skin.

21. The patterned neo-epithelium dressing of claim 20, wherein the interface member is formed with a fluid passageway that fluidly couples the first side and the second, patient-facing side.

23. The patterned neo-epithelium dressing of claim 20, wherein the interface member has a plurality of pores having an average pore size greater than 5 μ

m and smaller than 1000 μ

m.

26. The patterned neo-epithelium dressing of claim 20, wherein the plurality of three-dimensional features comprises an intact analogous human skin pattern.

27. The patterned neo-epithelium dressing of claim 20, wherein the plurality of three-dimensional features comprises a location-specific human skin pattern.

28. The patterned neo-epithelium dressing of claim 20, wherein the interface member comprises a medical-grade polymer.

31. The patterned neo-epithelium dressing of claim 20, wherein the interface member comprises a thin member bonded to a foam.

33. The patterned neo-epithelium dressing of claim 20, wherein the interface member comprises:

a thin member having a first side and a second, patient-facing side;

a hydrophilic material having a first side and a second, patient-facing side; and

wherein the second, patient-facing side of the hydrophilic material is coupled to the first side of the thin member.

34. The patterned neo-epithelium dressing of claim 20, further comprising a protein coated on the plurality of three-dimensional features.

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35. A method of treating a tissue site of a patient, the method comprising:

locating granulation tissue at the tissue site;

deploying a patterned neo-epithelium dressing comprising;

an interface member having a first side and a second, patient-facing side for placing proximate the granulation tissue, and

a plurality of three-dimensional features formed on the second, patient-facing side of the interface member, wherein the plurality of three-dimensional features comprises ridges mimicking human skin; and

applying a contact pressure on the patterned neo-epithelium dressing.

36. The method of claim 35, further comprising the step of promoting the formation of granulation tissue using reduced pressure.

37. The method of claim 36, wherein the step of promoting the formation of granulation tissue comprises applying a reduced-pressure manifold proximate to the tissue site, covering the reduced-pressure manifold with a sealing member, and providing reduced pressure to the reduced-pressure manifold.

38. The method of claim 35, wherein applying the contact pressure comprises:

deploying a sealing member over the patterned neo-epithelium dressing and a portion of the patient'"'"'s skin, the sealing member having a first side and a second, patient-facing side; and

providing reduced pressure to the second, patient-facing side of the sealing member.

39. The method of claim 35, wherein applying the contact pressure comprises deploying a pressure wrap over the first side of the patterned neo-epithelium dressing.

40. The method of claim 35, wherein the interface member has a plurality of pores having an average pore size greater than 5 μ

m and smaller than 1000 μ

m.

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