EPITHELIALIZATION METHODS, DRESSINGS, AND SYSTEMS

• US 20110230848A1
• Filed: 03/11/2011
• Published: 09/22/2011
• Est. Priority Date: 03/16/2010
• Status: Active Grant

• Current Assignee: KCI Licensing Incorporated (3M Company)
• Original Assignee: KCI Licensing Incorporated (3M Company)
• Inventors: Wilkes, Robert Peyton, Manwaring, Michael, Leung, Braden K.
• Granted Patent: US 8,808,258 B2
• Time in Patent Office: Days
• US Class Current: 604/290
• CPC Class Codes: A61F 13/00063 comprising medicaments or additives, e.g. odor control, PH control, debriding, antimicrobic drug delivery dressings A61K9/70; chemical aspect of the additives A61L15/00
• CPC Class Codes: A61F 13/01021 characterised by the structure of the dressing
• CPC Class Codes: A61F 13/05 specially adapted for use with sub-pressure or over-pressure therapy, wound drainage or wound irrigation, e.g. for use with negative-pressure wound therapy [NPWT]
• CPC Class Codes: A61F 2013/00089 Wound bandages A61F2013/00361 takes precedence;
• CPC Class Codes: A61M 1/915 Constructional details of the pressure distribution manifold
• CPC Class Codes: A61M 2210/04 Skin
• CPC Class Codes: A61P 17/02 for treating wounds, ulcers, burns, scars, keloids, or the like

Abstract

Methods, dressings, and systems for promoting epithelialization of a wound or other tissue are presented. The methods, dressings, and systems help form simulated rete pegs. In one instance, an epithelialization dressing is disclosed that may include a dressing body having a plurality of projections. A plurality of apertures is formed on a portion of the dressing body. The dressing helps manage fluids on the wound and the projections form cavities into which epithelial tissue migrates to from epithelial columns that function like rete pegs. Other dressings, methods, and systems are disclosed.

Claims

1. A method for treating a wound having granulation tissue in a wound bed, the method comprising the steps of:

deploying an epithelialization dressing proximate the granulation tissue in the wound bed, wherein the epithelialization dressing comprises;

a dressing body having a first side and a second, tissue-facing side, and

a plurality of projections, each projection having a proximal end and a distal end, the proximal end coupled to second, tissue-facing side of the dressing body;

causing a compression force on the epithelialization dressing such that the plurality of projections impinge upon the granulation tissue; and

allowing sufficient time for epithelium tissue to form proximate the projections.

2. The method of claim 1, further comprising:

wherein the epithelialization dressing further comprises a first plurality of apertures formed on a portion of the dressing body for allowing fluid communication between the first side of the dressing body and the second, tissue-facing side of the dressing body;

causing a fluid seal over the epithelialization dressing; and

providing reduced pressure to the epithialization dressing.

5. The method of claim 1, wherein the plurality of projections comprises a plurality of conically shaped projections having pores on the distal end.

6. The method of claim 1, wherein the plurality of projections further comprise supply reservoirs formed in an interior portion of the projections.

8. The method of claim 1, wherein the plurality of projections further comprise supply reservoirs formed in an interior portion of the projections and wherein the plurality of projections and the dressing body are formed of a bioresorbable material.

11. The method of claim 1, further comprising sub-features formed on the distal end of the plurality of projections and wherein the sub-features comprise ridges formed on the distal end of the projections of the plurality of projections.

13. The method of claim 1, wherein the projections of the plurality of projections have an aspect ratio (longer dimension for an average projection of the plurality of projections divided by a shorter dimension for the average projection of the plurality of projections) in the range of 1/10 to 10.

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17. A method of forming simulated rete pegs in a wound between granulation tissue and epithelium, the method comprising:

providing a plurality of projections;

placing the plurality of projections proximate the granulation tissue;

causing the plurality of projections to impinge upon the granulation tissue; and

allowing sufficient time for epithelial migration around the plurality of projections whereby simulated rete pegs are formed.

18. The method of claim 17, wherein the step of providing a plurality of projections comprises providing a epithelialization dressing having a dressing body to which the plurality of projections are coupled.

19. The method of claim 17, wherein the step of causing the plurality of projections to impinge upon the granulation tissue comprises:

deploying a sealing member over the epithelialization dressing and a portion of intact epidermis; and

providing reduced pressure to the epithelialization dressing.

20. An epithelialization dressing for forming anchor points between neo-epithelium tissue and an adjacent layer of tissue, the epithelialization dressing comprising:

a dressing body having a first side and a second, tissue-facing side;

a plurality of projections, each projection having a proximal end and a distal end, each proximal end coupled to the second, tissue-facing side of the dressing body, and wherein each projection has a longitudinal length in the range of 10 to 5000 microns;

a first plurality of apertures formed on a portion of the dressing body; and

sub-features formed on the distal end of each of the plurality of projections.

21. The epithelialization dressing of claim 20, wherein the sub-features comprise grooves formed on the distal end of the projections of the plurality of projections.

22. The epithelialization dressing of claim 20, wherein the sub-features comprise a plurality of ridges formed on the distal end of the projections of the plurality of projections.

25. The epithelialization dressing of claim 20, wherein the plurality of projections comprise a plurality of conically shaped projections, wherein each projection has an interior portion and a plurality of pores on the distal end, and wherein the pores provide fluid communication between the interior portion and an exterior of the projection for each projection.

27. The epithelialization dressing of claim 20, wherein the plurality of projections further comprise supply reservoirs formed in an interior portion of the projections.

28. The epithelialization dressing of claim 20, wherein the plurality of projections further comprise supply reservoirs formed in an interior portion of the projections and wherein the reservoirs contain soluble factors.

29. The epithelialization dressing of claim 20, wherein the plurality of projections further comprise supply reservoirs formed in an interior portion of the projections and wherein the plurality of projections and the dressing body are formed of a bioresorbable material.

30. The epithelialization dressing of claim 20, wherein the projections of the plurality of projections have an aspect ratio (longer dimension for an average projection of the plurality of projections divided by a shorter dimension for the average projection of the plurality of projections) in the range of 1/10 to 10.

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31. A system for promoting epithelialization of a wound, the system comprising:

an epithelialization dressing, the epithelialization dressing comprising;

a dressing body having a first side and a second, tissue-facing side,

a plurality of projections, each projection having a proximal end and a distal end, the proximal end coupled to the second, tissue-facing side of the dressing body, and wherein each projection has a longitudinal length in the range of 10 to 5000 microns,

a plurality of apertures formed on a portion of the dressing body, and

sub-features formed on the distal end of each of the plurality of projections;

a sealing member for forming a fluid seal over the wound and epithelialization dressing;

a reduced-pressure interface for providing reduced pressure to the epithelialization dressing; and

a reduced-pressure source fluidly coupled to the reduced-pressure interface.

32. The system for promoting epithelialization of a wound of claim 31, wherein the sub-features comprise grooves formed on the distal end of the projections of the plurality of projections.

34. The system for promoting epithelialization of a wound of claim 31, wherein the plurality of apertures comprise a plurality of slits.

36. The system for promoting epithelialization of a wound of claim 31, wherein the plurality of projections comprise a plurality of conically shaped projections having pores on the distal end.

37. The system for promoting epithelialization of a wound of claim 31, wherein the plurality of projections further comprise supply reservoirs formed in an interior portion of the projections.

39. The system for promoting epithelialization of a wound of claim 31, wherein the plurality of projections further comprise supply reservoirs formed in an interior portion of the projections and wherein the plurality of projections and the dressing body are formed of a bioresorbable material.

40. The system for promoting epithelialization of a wound of claim 31, wherein the projections of the plurality of projections have an aspect ratio (longer dimension for an average projection of the plurality of projections divided by a shorter dimension for the average projection of the plurality of projections) in the range of 1/10 to 10.

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