ANTIMICROBIAL LENSES, PROCESSES TO PREPARE THEM AND METHODS OF THEIR USE
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Abstract
This invention relates to solutions for packaging ophthalmic devices comprising at least one antimicrobial metal salt which prevent the loss of said antimicrobial metal salt during autoclaving and storage.
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Citations
22 Claims
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1-3. -3. (canceled)
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11. (canceled)
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13. (canceled)
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15-16. -16. (canceled)
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- 19. A method for reducing loss of an antimicrobial metal from an ophthalmic lens comprising at least one antimicrobial metal salt having a Ksp packaged in a packaging solution comprising the step of packaging said ophthalmic lens in a packaging solution having an osmolality of about 220 mOsm/kg or greater which is substantially free from packaging solution salts which have anions which when combined with cations from said antimicrobial metal form a salt having a Ksp between the Ksp of said antimicrobial metal salt and about 10−
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21. An article comprising
(a) an ophthalmic device comprising at least one antimicrobial metal salt having a Ksp of less than about 10− - 10
(b) stored in a packaging solution having an osmolality of about 220 mOsm/kg or greater and comprising only packaging solution salts which, upon autoclaving and storage of said ophthalmic device in said packaging solution, result in said ophthalmic device losing less than about 30% by weight of said antimicrobial metal salt.
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22. A solution for packaging an ophthalmic device comprising at least one antimicrobial metal salt having a Ksp wherein said solution has an osmolality of about 220 mOsm/kg or greater and comprises packaging solution salts, wherein said packaging solution salts have at least one anion which when combined with a cation from said antimicrobial metal salt forms a second salt having a Ksp which is at least about six orders of magnitude greater than said Ksp of said antimicrobial metal salt.
Specification