Antimicrobial polysiloxane materials containing metal species

• US 20110236343A1
• Filed: 03/25/2010
• Published: 09/29/2011
• Est. Priority Date: 09/28/2007
• Status: Active Grant

• Current Assignee: Ndsu-Research Foundation
• Original Assignee: Ndsu-Research Foundation
• Inventors: Majumdar, Partha, Chisholm, Bret Ja
• Granted Patent: US 8,709,394 B2
• Time in Patent Office: Days
• US Class Current: 424/78.17
• CPC Class Codes: A01N 2300/00 Combinations or mixtures of active ingredients covered by classes A01N27/00 - A01N65/48 with other active or formulation relevant ingredients, e.g. specific carrier materials or surfactants, covered by classes A01N25/00 - A01N65/48
• CPC Class Codes: A01N 25/04 Dispersions, emulsions, suspoemulsions, suspension concentrates or gels foams A01N25/16
• CPC Class Codes: A01N 25/10 Macromolecular compounds
• CPC Class Codes: A01N 25/28 Microcapsules or nanocapsules
• CPC Class Codes: A01N 33/12 Quaternary ammonium compounds
• CPC Class Codes: A01N 43/90 having two or more relevant hetero rings, condensed among themselves or with a common carbocyclic ring system
• CPC Class Codes: A01N 55/00 Biocides, pest repellants or attractants, or plant growth regulators, containing organic compounds containing elements other than carbon, hydrogen, halogen, oxygen, nitrogen and sulfur containing organo-phosphorus compounds A01N57/00
• CPC Class Codes: A01N 59/16 Heavy metals; Compounds thereof

Abstract

Polysiloxane-based materials, which include metal species, are provided. The polysiloxane-based compositions and materials generally include (i) amino-functional polysiloxane material and (ii) a plurality of metal species distributed within the polymeric material. Polymer based compositions in which the amino-functional polysiloxane material includes quaternary ammonium groups, e.g., tetraalkyl ammonium groups, are examples of suitable materials which may be used to form the present compositions. The metal species, which may be in an oxidized and/or neutral state, may be bonded, coordinated, chelated, suspended, and/or dispersed within the polymeric material.

Claims

1. A polymer-based composition comprising:

(A) quaternary amino functionalized cross-linked polysiloxane; and

(B) a plurality of silver species distributed within the polysiloxane.

2. The polymer-based composition of claim 1, wherein the silver species include silver(I) ions.

3. The polymer-based composition of claim 1 wherein the silver species include silver nanoparticles.

4. The polymer-based composition of claim 1, comprising an antimicrobially-effective amount of the silver species.

5. The polymer-based composition of claim 4, wherein the silver species are in releasable form.

6. The polymer-based composition of claim 4, further comprising a second antimicrobial agent.

7. The polymer-based composition of claim 6, wherein the second antimicrobial agent comprises chlorhexidine, triclosan, gramicidin, polymixin, norfloxacin, sulfamylon, polyhexamethylene biguanide, alexidine, levofloxacin, minocycline, iodine, benzalkonium chloride, rifampicin, or a combination thereof.

8. The polymer-based composition of claim 1, further comprising an antifungal agent.

9. The polymer-based composition of claim 1, wherein the silver species are distributed throughout the polysiloxane.

10. The polymer-based composition of claim 1, wherein the quaternary amino functionalized cross-linked polysiloxane comprises polymer formed by reacting a mixture which includes alkoxysilyl functionalized quaternary amine and silanol terminated polysiloxane.

11. The polymer-based composition of claim 1, wherein the quaternary amino functionalized cross-linked polysiloxane comprises a quaternary ammonium salt of a polyamine cross-linked polysiloxane.

12. A coating comprising the polymer-based composition of claim 1.

13. The coating of claim 12, wherein the silver species are predominantly concentrated in an outer portion of the coating.

14. The coating of claim 12, wherein the silver species are distributed throughout the coating.

15. The coating of claim 14, wherein the silver species comprise silver nanoparticles.

16. An antimicrobial polymer-based composition comprising:

(A) quaternary amino functionalized cross-linked polysiloxane; and

(B) a plurality of metal species distributed within the crosslinked polysiloxane.

17. The polymer-based composition of claim 16, wherein the metal species include silver, zinc, cadmium, mercury, antimony, gold, aluminum, copper, platinum, titanium and/or palladium species.

18. The polymer-based composition of claim 16, further comprising an antimicrobial agent selected from chlorhexidine, triclosan, gramicidin, levofloxacin, polymixin, norfloxacin, sulfamylon, polyhexamethylene biguanide, alexidine, minocycline, iodine, benzalkonium chloride and/or rifampicin.

19. A method of forming an antimicrobial coating comprising:

forming a coating layer on the surface of a substrate;

wherein the coating layer includes quaternary amino functionalized cross-linked polysiloxane; and

exposing the coating layer to a solution containing metal species.