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SELECTIVE OXIDATION OF 5-METHYLCYTOSINE BY TET-FAMILY PROTEINS

  • US 20110236894A1
  • Filed: 09/28/2009
  • Published: 09/29/2011
  • Est. Priority Date: 09/26/2008
  • Status: Active Grant
First Claim
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1. A method for improving the generation of stable human Foxp3+ T cells, the method comprising contacting with, or delivering to, a human T cell an effective 5-methylcytosine to 5-hydroxymethylcytosine converting amount of at least one catalytically active TET family enzyme, functional TET family derivative, TET family catalytically active fragment thereof, or combination thereof.

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