DENTAL STEM CELL DIFFERENTIATION
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Abstract
Provided is a method of preparing an embryonic stem cell-like cell, a method of preparing an insulin-secreting cell or pancreatic beta-like cell, a method of preparing a chondrocyte-like cell, a method of preparing a myocyte-like cell, and a method of preparing a hair follicle-like cell. A composition comprising a dental stem cell and an insulin-secreting cell or a pancreatic beta-like cell is also provided. Further, a composition comprising (a) a dental stem cell and (b) a chondrocyte-like cell, a myocyte-like cell, or a hair follicle-like cell is provided. Additionally provided is an insulin-secreting cell or a pancreatic beta-like cell differentiated from a dental stem cell. Further provided is a chondrocyte-like cell, a myocyte-like cell, or a hair follicle-like cell, derived from a dental stem cell.
11 Citations
57 Claims
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1-37. -37. (canceled)
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38. A method of differentiating a dental stem cell comprising:
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incubating a dental stem cell in a medium that induces the differentiation of a dental stem cell into an insulin-secreting cell under conditions such that the dental stem cell differentiates into the insulin-secreting cell or pancreatic beta-like cell; incubating a dental stem cell in a medium that induces the differentiation of a dental stem cell into a chondrocyte-like cell under conditions such that the dental stem cell differentiates into the chondrocyte-like cell; incubating a dental stem cell in a medium that induces the differentiation of a dental stem cell into a myocyte-like cell under conditions such that the dental stem cell differentiates into the myocyte-like cell;
orincubating a dental stem cell in a medium that induces the differentiation of a dental stem cell into a hair follicle-like cell under conditions such that the dental stem cell differentiates into the hair follicle-like cell. - View Dependent Claims (39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52)
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53. A composition comprising:
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(i) (a) a dental stem cell and (b) an insulin-secreting cell or a pancreatic beta-like cell; (ii) (a) a dental stem cell and (b) a chondrocyte-like cell, a myocyte-like cell, or a hair follicle-like cell; (iii) a pancreatic beta-like cell differentiated from a dental stem cell;
or(iv) a chondrocyte-like cell, a myocyte-like cell, or a hair follicle-like cell, derived from a dental stem cell.
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54. A method of preparing an embryonic stem cell-like cell comprising:
- culturing a dental stem cell in a medium that maintains an embryonic stem cell under conditions such that the dental stem cell dedifferentiates into the embryonic stem cell-like cell.
- View Dependent Claims (55, 56, 57)
Specification