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MODULATION OF TRANSTHYRETIN EXPRESSION FOR THE TREATMENT OF CNS RELATED DISORDERS

  • US 20110237646A1
  • Filed: 08/07/2009
  • Published: 09/29/2011
  • Est. Priority Date: 08/07/2008
  • Status: Abandoned Application
First Claim
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1. A method of inhibiting transthyretin in the brain of an animal comprising;

  • administering a modified oligonucleotide consisting of 12 to 30 linked nucleosides, wherein the modified oligonucleotide is complementary to human transthyretin; and

    thereby inhibiting transthyretin in the brain of an animal.

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