BLOOD BAG SYSTEM AND CASSETTE

• US 20110238029A1
• Filed: 11/18/2009
• Published: 09/29/2011
• Est. Priority Date: 11/28/2008
• Status: Abandoned Application

• Current Assignee: Terumo Kabushiki Kaisha
• Original Assignee: Terumo Kabushiki Kaisha
• Inventors: Biset, Roland, Hirabuki, Makoto
• Application Number:
  US13/131,054
• Publication Number:
  US 20110238029A1
• Time in Patent Office: Days
• US Class Current: 604/410
• CPC Class Codes: A61J 1/10 Bag-type containers
• CPC Class Codes: A61M 1/0218 with filters
• CPC Class Codes: A61M 1/0227 and means for securing the filter against damage, e.g. during centrifugation
• CPC Class Codes: A61M 1/029 Separating blood components present in distinct layers in a container, not otherwise provided for containers for storing blood or blood components A61J1/05; sampling or analysing blood by separating blood components G01N33/491
• CPC Class Codes: A61M 1/36222 Details related to the interface between cassette and machine
• CPC Class Codes: A61M 1/36224 with sensing means or components thereof
• CPC Class Codes: A61M 1/36226 Constructional details of cassettes, e.g. specific details on material or shape
• CPC Class Codes: A61M 1/362265 Details of valves
• CPC Class Codes: A61M 1/3693 using separation based on different densities of components, e.g. centrifuging
• CPC Class Codes: A61M 2205/12 with interchangeable cassettes forming partially or totally the fluid circuit
• CPC Class Codes: B01D 21/262 by using a centrifuge
• CPC Class Codes: B04B 2005/0435 with adapters for centrifuge tubes or bags
• CPC Class Codes: B04B 2005/0478 with filters in the separation chamber
• CPC Class Codes: B04B 5/0428 with flexible receptacles
• CPC Class Codes: B04B 7/16 Sieves or filters filters in general B01D; sieves in general B07B

Abstract

A blood bag system includes a BC pooling bag for centrifugation of a buffy coat, a filter for removing white blood cells from a supernatant liquid transferred from the BC pooling bag, a platelet preserving bag for reserving the supernatant liquid that has passed through the filter, a first tube connecting the BC pooling bag and an inlet of the filter, a second tube connecting the platelet preserving bag and an outlet of the filter, and a cassette to be fixed in the centrifugation and separation apparatus. The first tube and the second tube are disposed within the cassette. The cassette includes a first clamp section for closing and opening the first tube, and a second clamp section for closing and opening the second tube.

Claims

1. A blood bag system comprising:

a first bag for reserving whole blood or a blood component;

a filter having a filter medium for removing predetermined cells from a blood component obtained by centrifugation of the liquid contained in the first bag;

a second bag for reserving a blood component obtained upon removal of the predetermined cells by the filter;

a first tube for connecting the first bag and an inlet of the filter;

a second tube for connecting the second bag and an outlet of the filter; and

a cassette for holding a part of the first tube and a part of the second tube,

wherein the cassette has a first clamp section for closing and opening the first tube and a second clamp section for closing and opening the second tube.

2. The blood bag system according to claim 1, wherein the first clamp section and the second clamp section are configured integrally with the cassette.

3. The blood bag system according to claim 1, wherein the first clamp section and the second clamp section each includes:

a pressing section which can be elastically advanced and retracted, and which presses the first tube or the second tube from a lateral side thereof;

an acute-angular engaged portion provided at a tip of the pressing section;

a latch section which can be elastically tilted; and

an engaging portion which is provided on the latch section and which engages with the engaged portion of the pressing section while in a state of pressing the first tube or the second tube.

8. The blood bag system according to claim 1, wherein whole blood or a blood component collected from a plurality of donors is reserved in the first bag, and

the blood bag system is mounted in a centrifugation and separation apparatus for centrifuging the liquid contained in the first bag into a supernatant liquid and a sedimentary liquid, removing a predetermined component from the supernatant liquid by the filter, and for transferring the supernatant liquid, deprived of the predetermined component, into the second bag.

9. The blood bag system according to claim 2, wherein the centrifugation and separation apparatus includes a first sensor and a second sensor, each of which has a light emitting section and a light receiving section, and which detects the kind of liquid passing between the light emitting section and the light receiving section,

the cassette has a sensor hole in which the first sensor and the second sensor are inserted, and

the first tube is located so as to pass between the light emitting section and the light receiving section of the first sensor, whereas the second tube is located so as to pass between the light emitting section and the light receiving section of the second sensor.

4. A blood bag system comprising:

a first bag for reserving whole blood or a blood component;

a filter having a filter medium for removing predetermined cells from a blood component obtained by centrifugation of the liquid contained in the first bag;

a second bag for reserving a blood component obtained upon removal of the predetermined cells by the filter;

a first tube for connecting the first bag and an inlet of the filter;

a second tube for connecting the second bag and an outlet of the filter;

a first clamp for closing and opening the first tube;

a second clamp for closing and opening the second tube; and

a cassette for holding a part of the first tube, a part of the second tube, the first clamp and the second clamp,

wherein the cassette has a first clamp operating section for operating the first clamp and a second clamp operating section for operating the second clamp.

5. The blood bag system according to claim 4, wherein the first clamp operating section and the second clamp operating section are configured integrally with the cassette.

6. The blood bag system according to claim 4, wherein the first clamp operating section and the second clamp operating section each includes:

a pressing section which can be elastically advanced and retracted, and which presses the first tube or the second tube from a lateral side thereof through the first clamp and the second clamp;

an acute-angular engaged portion provided at a tip of the pressing section;

a latch section which can be elastically tilted; and

an engaging portion, which is provided on the latch section, and which engages with the engaged portion of the pressing section while in a state of pressing the first tube or the second tube through the first clamp and the second clamp.

7. The blood bag system according to claim 4, wherein the first clamp and the second clamp are arranged in parallel within the cassette.

12. The blood bag system according to claim 4, wherein whole blood or a blood component collected from a plurality of donors is reserved in the first bag, and

the blood bag system is mounted in a centrifugation and separation apparatus for centrifuging the liquid contained in the first bag into a supernatant liquid and a sedimentary liquid, removing a predetermined component from the supernatant liquid by the filter, and for transferring the supernatant liquid, deprived of the predetermined component, into the second bag.

13. The blood bag system according to claim 5, wherein the centrifugation and separation apparatus includes a first sensor and a second sensor, each of which has a light emitting section and a light receiving section, and which detects the kind of liquid passing between the light emitting section and the light receiving section,

the cassette has a sensor hole in which the first sensor and the second sensor are inserted, and

the first tube is located so as to pass between the light emitting section and the light receiving section of the first sensor, whereas the second tube is located so as to pass between the light emitting section and the light receiving section of the second sensor.

10. A cassette mounted to a multiple bag comprising:

a first bag for reserving whole blood or a blood component;

a filter having a filter medium for removing predetermined cells from a blood component obtained by centrifugation of the liquid contained in the first bag;

a second bag for reserving a blood component obtained upon removal of the predetermined cells by the filter;

a first tube for connecting the first bag and an inlet of the filter; and

a second tube for connecting the second bag and an outlet of the filter,

wherein the cassette holds a part of the first tube and a part of the second tube, and includes a first clamp section for closing and opening the first tube and a second clamp section for closing and opening the second tube.

11. A cassette mounted to a multiple bag comprising:

a first bag for reserving whole blood or a blood component;

a filter having a filter medium for removing predetermined cells from a blood component obtained by centrifugation of the liquid contained in the first bag;

a second bag for reserving a blood component obtained upon removal of the predetermined cells by the filter;

a first tube for connecting the first bag and an inlet of the filter;

a second tube for connecting the second bag and an outlet of the filter;

a first clamp for closing and opening the first tube; and

a second clamp for closing and opening the second tube,

wherein the cassette holds a part of the first tube, a part of the second tube, the first clamp and the second clamp, and includes a first clamp operating section for operating the first clamp and a second clamp operating section for operating the second clamp.