OPTIMIZED METHOD FOR LID BIOSENSOR RESONANCE DETECTION
First Claim
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1. An optical interrogation system comprising:
- a launch system that emits an optical beam towards a biosensor;
a receive system that collects an optical beam from the biosensor and then outputs a signal which corresponds to the collected optical beam; and
the receive system includes a spectrometer which has a misaligned entrance spectrometer slit or fiber.
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Abstract
An optical interrogation system is described herein that can interrogate a label-independent-detection (LID) biosensor and monitor a biological event on top of the biosensor without suffering from problematical parasitic reflections and/or problematical pixelation effects.
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Citations
23 Claims
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1. An optical interrogation system comprising:
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a launch system that emits an optical beam towards a biosensor; a receive system that collects an optical beam from the biosensor and then outputs a signal which corresponds to the collected optical beam; and the receive system includes a spectrometer which has a misaligned entrance spectrometer slit or fiber.
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2. An optical interrogation system comprising:
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a launch system that emits an optical beam towards a biosensor; a receive system that collects an optical beam from the biosensor and then outputs a signal which is representative of the collected optical beam; and a processor that reduces pixelation oscillations in an optical resonance of the signal by oversampling at least a portion of the optical resonance, smoothing the optical resonance and calculating a resonance location or centroid that is based on the smoothed-oversampled optical resonance. - View Dependent Claims (3, 4, 5, 6, 7)
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8. A method for interrogating a biosensor, said method comprising the steps of:
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emitting an optical beam towards a biosensor; collecting an optical beam from the biosensor generating a signal which corresponds to the collected optical; and reducing oscillations in an optical resonance of the signal caused by a problematical pixelation effect by; oversampling at least a portion of the optical resonance; smoothing the optical resonance; and calculating a resonance location or centroid that is based on the smoothed-oversampled optical resonance. - View Dependent Claims (9, 10, 11, 12, 13, 14, 15)
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16. An optical interrogation system comprising:
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a launch system that emits an optical beam towards a biosensor; a receive system that collects an optical beam from the biosensor and then outputs a signal which corresponds to the collected optical beam; and a processor that applies a low pass filter to the signal, wherein the low pass filter has a low pass filter width wide enough to suppress detrimental effects of parasitic fringes located on each side of an optical resonance represented within the signal by applying the low pass filter to the signal, wherein the parasitic fringes are generated at least by presence of linearly polarized parasitic reflections, and wherein the linearly polarized parasitic reflections are caused by the optical beam which passes through a substrate of the biosensor and is then reflected from a top surface of the biosensor. - View Dependent Claims (17, 18)
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19. A method for interrogating a biosensor, said method comprising the steps of:
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emitting an optical beam towards the biosensor; collecting an optical beam from the biosensor; generating a signal which corresponds to the collected optical beam; and applying a low pass filter to the signal, wherein the low pass filter has a low pass filter width wide enough to suppress detrimental effects of parasitic fringes located on each side of an optical resonance represented within the signal by applying the low pass filter to the signal, wherein the parasitic fringes are generated at least by presence of linearly polarized parasitic reflections, and wherein the linearly polarized parasitic reflections are caused by the optical beam which passes through a substrate of the biosensor and is then reflected from a top surface of the biosensor. - View Dependent Claims (20, 21, 22, 23)
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Specification