IMPLANTABLE MEDICAL ARTICLES HAVING LAMININ COATINGS AND METHODS OF USE
First Claim
1. An implantable medical article having a coating comprisinga first component comprising laminin, an active portion thereof, or a binding member thereof, anda second component comprising collagen I or collagen IV, an active portion thereof, or a binding member thereof,wherein the coating further comprises a polymeric component, a first group reacted to form a layer comprising the polymeric component, and second groups reacted to individually bond first and second components to the polymeric component,wherein upon implantation in a subject, the coating enhances adhesion of endothelial cells to the implantable medical article.
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Accused Products
Abstract
Laminin-containing coatings for the surfaces of implantable medical devices are disclosed. The coatings promote the formation of vessels in association with the coated surfaces with minimal fibrotic response.
31 Citations
20 Claims
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1. An implantable medical article having a coating comprising
a first component comprising laminin, an active portion thereof, or a binding member thereof, and a second component comprising collagen I or collagen IV, an active portion thereof, or a binding member thereof, wherein the coating further comprises a polymeric component, a first group reacted to form a layer comprising the polymeric component, and second groups reacted to individually bond first and second components to the polymeric component, wherein upon implantation in a subject, the coating enhances adhesion of endothelial cells to the implantable medical article.
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18. An implantable medical article having a coating comprising
a first component comprising laminin, an active portion thereof, or a binding member thereof, and a second component comprising an adhesion factor, an active portion thereof, or a binding member thereof, wherein the coating further comprises a polymeric component, a first group reacted to form a layer comprising the polymeric component, and second groups reacted to individually bond first and second components to the polymeric component.
- 19. An implantable medical article comprising a stably denucleated porous portion.
Specification