PEPTIDE AGONISTS OF GLP-1 ACTIVITY
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Abstract
Novel peptide agonists of GLP-1 activity useful for lowering blood glucose levels. The novel peptides comprise variants of the GLP-1 or the exendin-4 polypeptide sequence and are pharmacologically active and stable. These peptides are useful in the treatment of diseases that benefit from regulation of excess levels of blood glucose and/or regulation of gastric emptying, such as diabetes and eating disorders.
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Citations
18 Claims
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1. (canceled)
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2. A method for treating type 2 diabetes mellitus in a subject in need thereof, said method comprising administering to said subject (i) a peptide conjugate comprising an exendin-4 variant coupled via its C-terminus to an amino acid sequence Z, wherein said exendin-4 variant comprises a sequence characterized by deletion of between 1 and 5 amino acid residues at positions corresponding to positions 34-38 of exendin-4(1-39) and wherein Z comprises from 4 to 20 Lys amino acid residues, or a pharmaceutically acceptable salt thereof;
- and (ii) an antidiabetic agent each in an amount that together is effective for the treatment of type 2 diabetes mellitus.
- View Dependent Claims (3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18)
Specification