SYSTEM AND METHOD FOR DELIVERY OF SUSPENSIONS AND OTHER MICROPARTICLE COMPOSITIONS
First Claim
Patent Images
1. A system for delivery of a suspension, comprising:
- a needle;
a cartridge having an internal cavity into which a predetermined amount of the suspension is sealed therein, the cartridge having an outer surface and a distal end configured for fluid-tight connection to the needle;
an axially movable plunger positioned in a friction fit within the internal cavity of the cartridge; and
sonic energy-generating means configured to contact at least a portion of the outer surface of the cartridge,wherein, during movement of the axially movable plunger, the sonic energy-generating means can be selectively activated to eliminate blockages within the internal cavity of the cartridge.
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0 Petitions
Accused Products
Abstract
Disclosed herein are systems and methods useful for delivery of suspensions and other microparticle compositions, and, in particular, for delivering microparticles at desired dosing levels and eliminating blockages within microparticle suspensions positioned within a delivery device.
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Citations
62 Claims
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1. A system for delivery of a suspension, comprising:
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a needle; a cartridge having an internal cavity into which a predetermined amount of the suspension is sealed therein, the cartridge having an outer surface and a distal end configured for fluid-tight connection to the needle; an axially movable plunger positioned in a friction fit within the internal cavity of the cartridge; and sonic energy-generating means configured to contact at least a portion of the outer surface of the cartridge, wherein, during movement of the axially movable plunger, the sonic energy-generating means can be selectively activated to eliminate blockages within the internal cavity of the cartridge. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12)
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13. A system for delivery of a microparticle composition, comprising:
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a first cartridge having an internal cavity into which a predetermined amount of a suspension vehicle is sealed therein; a second cartridge having an internal cavity into which a predetermined amount of microparticles is sealed therein; a connector having an internal bore extending between a first end and a second end, the connector configured to selectively connect to a distal end of the first cartridge and into communication with the internal cavity of the first cartridge and to selectively connect to a distal end of the second cartridge and into communication with the internal cavity of the second cartridge; means for introducing the suspension vehicle from the first cartridge through the connector and into the internal cavity of the second cartridge; and means for substantially uniformly mixing the predetermined amount of microparticles and the predetermined amount of suspension vehicle to form a heterogeneous mixture in which the microparticles are distributed substantially uniformly throughout the suspension vehicle, wherein the heterogeneous mixture has a predetermined dosing level of microparticles. - View Dependent Claims (14)
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38. A method for delivering a suspension, comprising:
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providing a cartridge having an internal cavity into which a predetermined amount of the suspension is sealed therein, the cartridge having an outer surface and a distal end configured for fluid-tight connection to a needle; selectively axially moving a plunger positioned in a friction fit within the internal cavity of the cartridge; contacting at least a portion of the outer surface of the cartridge with sonic energy-generating means; and selectively activating the sonic energy-generating means to eliminate blockages within the internal cavity of the cartridge. - View Dependent Claims (39, 40, 41, 42, 43, 44, 45, 46, 47)
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Specification