TELOMERASE INHIBITORS AND METHODS OF USE THEREOF
First Claim
Patent Images
1. A telomerase inhibitor, the telomerase inhibitor comprising a nucleic acid or analog thereof, which binds to the CR4-CR5 domain of the RNA component of human telomerase.
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Abstract
One object of the present invention is to provide methods and compositions for inhibiting human telomerase, by providing inhibitors that bind to the CR4-CR5 or pseudoknot/template domains of the RNA component of human telomerase.
20 Citations
54 Claims
- 1. A telomerase inhibitor, the telomerase inhibitor comprising a nucleic acid or analog thereof, which binds to the CR4-CR5 domain of the RNA component of human telomerase.
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3-4. -4. (canceled)
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6. The telomerase inhibitor of claim, wherein said nucleic acid or analog thereof comprises a binding sequence length of 4-20 nucleotides.
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8. (canceled)
- 9. A method of inhibiting telomerase activity, the method comprising contacting a telomerase with a nucleic acid or analog thereof, which binds to the CR4-CR5 domain of the RNA component of human telomerase.
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11-12. -12. (canceled)
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16-25. -25. (canceled)
- 26. A method of treating a proliferative disorder in a subject in need thereof, the method comprising administering to the subject an effective amount of a telomerase inhibitor, wherein said telomerase inhibitor comprises a nucleic acid or analog thereof, which binds to the CR4-CR5 domain of the RNA component of human telomerase.
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28-29. -29. (canceled)
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33-34. -34. (canceled)
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36-42. -42. (canceled)
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43. A telomerase inhibitor, the inhibitor comprising a nucleic acid molecule or analog thereof, which binds to the pseudoknot/template domain of the RNA component of human telomerase, wherein said nucleic acid molecule or analog thereof comprises a binding sequence selected from the group consisting of SEQ ID NO:
- 11-SEQ. ID NO;
45. - View Dependent Claims (44, 53)
- 11-SEQ. ID NO;
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45. (canceled)
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46. A method of inhibiting telomerase activity in a cell, the method comprising contacting a cell with a ribonucleic acid molecule or analog thereof, which binds to the pseudoknot/template domain of the RNA component of human telomerase, wherein said ribonucleic acid molecule or analog thereof comprises a binding sequence selected from the group consisting of SEQ ID NO:
- 11-SEQ. ID NO;
45.
- 11-SEQ. ID NO;
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47-52. -52. (canceled)
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54-55. -55. (canceled)
Specification