Flux Enhancement in Continuous Glucose Monitoring
First Claim
1. A method of in vivo monitoring of an individual'"'"'s interstitial fluid analyte concentration comprising:
- creating a plurality of fluid paths through a stratum corneum layer of an area of the individual'"'"'s skin, said fluid paths each comprising a distal end in fluid communication with interstitial fluid of the individual, a proximal end in fluid communication with a sensing zone located outside of the patient'"'"'s body, an interior space extending between the distal and proximal ends of the fluid paths, and a sensing fluid filling substantially the entire interior space;
allowing at least one analyte to passively diffuse from the patient'"'"'s interstitial fluid through the fluid paths and into the sensing zone; and
sensing a concentration of the at least one analyte in a sensing fluid within the sensing zone using a sensor located at least partially in the sensing zone, wherein the sensing fluid comprises an agent adapted to increase an analyte flux through the fluid paths and to mitigate a decrease over time of the analyte flux through the fluid paths.
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Accused Products
Abstract
One aspect of the invention is a method of in vivo monitoring of an individual'"'"'s interstitial fluid glucose concentration comprising inserting a plurality of tissue piercing elements through a stratum corneum layer of an area of the individual'"'"'s skin. The tissue piercing elements each comprise a distal end in fluid communication with interstitial fluid of the individual, and a proximal end in fluid communication with a sensing zone located outside of the patient'"'"'s body. An interior space extends between the distal and proximal ends of the tissue piercing elements. A sensing fluid fills substantially the entire interior space and the sensing fluid concentration comprises a concentration of citrate in a buffer solution. The concentration of citrate may range from 100 mM to 200 mM, preferably 135-165 mM.
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Citations
13 Claims
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1. A method of in vivo monitoring of an individual'"'"'s interstitial fluid analyte concentration comprising:
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creating a plurality of fluid paths through a stratum corneum layer of an area of the individual'"'"'s skin, said fluid paths each comprising a distal end in fluid communication with interstitial fluid of the individual, a proximal end in fluid communication with a sensing zone located outside of the patient'"'"'s body, an interior space extending between the distal and proximal ends of the fluid paths, and a sensing fluid filling substantially the entire interior space; allowing at least one analyte to passively diffuse from the patient'"'"'s interstitial fluid through the fluid paths and into the sensing zone; and sensing a concentration of the at least one analyte in a sensing fluid within the sensing zone using a sensor located at least partially in the sensing zone, wherein the sensing fluid comprises an agent adapted to increase an analyte flux through the fluid paths and to mitigate a decrease over time of the analyte flux through the fluid paths. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8)
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9. An analyte monitor comprising:
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a plurality of fluid paths, each fluid path comprising a distal opening adapted to be disposed on one side of a stratum corneum layer of a user'"'"'s skin, a proximal opening adapted to be disposed on another side of the stratum corneum layer and an interior space extending between the distal and proximal openings; a sensing zone in fluid communication with the proximal openings of the fluid paths; sensing fluid extending from the sensing zone into substantially the entire interior space of the fluid paths, wherein the sensing fluid comprises an agent adapted to increase an analyte flux through the fluid paths and to mitigate a decrease over time of the analyte flux through the fluid paths; and an analyte sensor adapted to detect a concentration of analyte in the sensing fluid within the sensing zone. - View Dependent Claims (10, 11, 12, 13)
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Specification