THERAPY PREDICTION AND OPTIMIZATION FOR RENAL FAILURE BLOOD THERAPY, ESPECIALLY HOME HEMODIALYSIS
First Claim
1. A method of predicting serum phosphorus concentrations in a patient during hemodialysis, the method comprising:
- measuring serum phosphorus concentrations (“
C”
) of the patient over a hemodialysis treatment session time and an ultrafiltration rate (“
QUF”
) calculated by a difference between pre- and post-dialytic body weight of the patient during an initial hemodialysis treatment session divided by a total treatment time of the treatment session;
estimating KM and VPRE for the patient using a non-linear least squares fitting to the equations;
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Abstract
A method of predicting serum phosphorus concentrations in a patient during hemodialysis includes measuring serum phosphorus concentrations of the patient over a hemodialysis treatment session time and an ultrafiltration rate calculated by a difference between pre- and post-dialytic body weight of the patient during an initial hemodialysis treatment session divided by a total treatment time of the treatment session and estimating a phosphorous mobilization clearance and a pre-dialysis distribution volume of phosphorus for the patient. Serum phosphorus concentrations of the patient can then be predicted at any time during any hemodialysis treatment session with the estimated phosphorous mobilization clearance and pre-dialysis distribution volume of phosphorus of the patient.
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Citations
50 Claims
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1. A method of predicting serum phosphorus concentrations in a patient during hemodialysis, the method comprising:
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measuring serum phosphorus concentrations (“
C”
) of the patient over a hemodialysis treatment session time and an ultrafiltration rate (“
QUF”
) calculated by a difference between pre- and post-dialytic body weight of the patient during an initial hemodialysis treatment session divided by a total treatment time of the treatment session;estimating KM and VPRE for the patient using a non-linear least squares fitting to the equations; - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12)
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13. A method of predicting serum phosphorus concentrations in a patient during hemodialysis, the method comprising:
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measuring serum phosphorus concentrations (“
C”
) of the patient over a hemodialysis treatment session time for an ultrafiltration rate (“
QUF”
)=0 during an initial hemodialysis treatment session;estimating KM and VPRE for the patient using a non-linear least squares fitting to the equations; - View Dependent Claims (14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24)
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25. A computing device comprising:
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a display device; an input device; a processor; and a memory device that stores a plurality of instructions, which when executed by the processor, cause the processor to operate with the display device and the input device to; (a) receive data relating to serum phosphorus concentrations (“
C”
) of a hemodialysis patient over a hemodialysis treatment session time and an ultrafiltration rate (“
QUF”
) calculated by a difference between pre- and post-dialytic body weight of the hemodialysis patient during a hemodialysis treatment session divided by a total treatment time of the treatment session;(b) estimate KM and VPRE for the patient using a non-linear least squares fitting to the equations; - View Dependent Claims (26, 27)
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28. A method of determining steady state, pre-dialysis serum phosphorus levels in a hemodialysis patient, the method comprising:
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obtaining a net generation of phosphorus (“
G”
) of the hemodialysis patient;determining steady state, pre-dialysis serum phosphorus levels (“
CSS-PRE”
) of the hemodialysis patient using the equation; - View Dependent Claims (29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44)
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45. A computing device comprising:
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a display device; an input device; a processor; and a memory device that stores a plurality of instructions, which when executed by the processor, cause the processor to operate with the display device and the input device to; (a) receive data relating to a net generation of phosphorus (“
G”
) from at least a dietary phosphorus intake of a hemodialysis patient or a urea kinetic modeling of the hemodialysis patient;(b) determine steady state, pre-dialysis serum phosphorus levels (“
CSS-PRE”
) of the patient using the equation; - View Dependent Claims (46, 47)
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48. A computing device comprising:
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a display device; an input device; a processor; and a memory device that stores a plurality of instructions, which when executed by the processor, cause the processor to operate with the display device and the input device to; (a) determine a net generation of phosphorus (“
G”
) using the equation; - View Dependent Claims (49, 50)
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Specification