PERSONALISED PHARMACEUTICAL COMPOSITION CONTAINING RETINOIC ACID, FOR ANTI-AGING OF THE SKIN

• US 20110262373A1
• Filed: 04/09/2009
• Published: 10/27/2011
• Est. Priority Date: 04/23/2008
• Status: Abandoned Application

• Current Assignee: Ignacio Umbert Millet
• Original Assignee: Ignacio Umbert Millet
• Inventors: Umbert Millet, Ignacio
• Application Number:
  US12/988,963
• Publication Number:
  US 20110262373A1
• Time in Patent Office: Days
• US Class Current: 424/62
• CPC Class Codes: A61K 8/671 Vitamin A; Derivatives thereof, e.g. ester of vitamin A acid, ester of retinol, retinol, retinal
• CPC Class Codes: A61P 17/00 Drugs for dermatological disorders
• CPC Class Codes: A61P 29/00 Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
• CPC Class Codes: A61Q 19/08 Anti-ageing preparations

Abstract

The invention relates to a personalised pharmaceutical composition for anti-aging of the skin, in the form of an ointment, comprising a first group of common active principles present in any formulation, formed by retinoic acid, at least one anti-inflammatory agent, at least one additional depigmenting agent, at least one anti-oxidant and at least one vitamin; and a second group of variable active principles present in variable quantities formulated according to the metabolic characteristics of the particular user. The anti-inflammatory agent is indomethacin. The depigmenting agents can be selected from the group consisting of hydroquinone, kojic acid, mequinol, phytic acid and alpha-arbutin. The anti-oxidants can be selected from the group consisting of lipoic acid, lycopene, coenzyme Q10, resveratrol, pycnogenol®, L-carnosine, taurine, N-acetylglucosamine, ascorbic acid, isoflavones and tocotrienol. The second group of variable active principles can comprise hyaluronic acid, aloe vera, bilberry glycolic extract, centella glycolic extract, allantoin, organic silicon, niacinamide and a cicatrizant.

Claims

1. A personalized pharmaceutical composition for skin rejuvenation comprising a first group of common active ingredients comprising retinoic acid, one or more anti-inflammatory agents, one or more depigmenting agents, one or more antioxidants, and one or more vitamins;

and a second group of variable active ingredients, wherein at least one anti-inflammatory agent is indomethacin.

2. The personalized pharmaceutical composition for skin rejuvenation of claim 1, wherein said depigmenting agents are selected from the group consisting of hydroquinone, kojic acid, mequinol, phytic acid, and alpha-arbutin.

3. The personalized pharmaceutical composition for skin rejuvenation of claim 1, wherein said antioxidant is selected from the group consisting of lipoic acid, lycopene, coenzyme Q 10, resveratrol, pycnogenol®

, L-carnosine, taurine, N-acetylglucosamine, ascorbic acid, isoflavones, and tocotrienol.

4. The personalized pharmaceutical composition for skin rejuvenation of claim 1, wherein said vitamins are selected from the group consisting of vitamin E acetate, and vitamin C.

5. The personalized pharmaceutical composition for skin rejuvenation of claim 1, wherein said first group of common active ingredients comprises

between 0.010 and 1% by weight of retinoic acid;

between 1 and 4% by weight of indomethacin;

between 1 and 6% hydroquinone;

between 1 and 5% kojic acid;

between 1 and 3% mequinol;

between 1 and 6% lipoic acid;

between 2 and 6% vitamin E acetate, and

between 1 and 6% vitamin C.

6. The personalized pharmaceutical composition for skin rejuvenation of claim 5, wherein the second group of variable active ingredients comprises hyaluronic acid.

7. The personalized pharmaceutical composition for skin rejuvenation of claim 6, wherein said hyaluronic acid is present in an amount between 0.1 and 1.5% by weight.

8. The personalized pharmaceutical composition for skin rejuvenation of claim 1, wherein said second group of variable active ingredients comprises up to 15% by weight of aloe vera.

9. The personalized pharmaceutical composition for skin rejuvenation of claim 1, wherein said second group of variable active ingredients comprises between 1 and 5% of bilberry glycolic extract.

10. The personalized pharmaceutical composition for skin rejuvenation of claim 1, wherein said second group of variable active ingredients comprises between 1 and 5% of Centella glycolic extract.

11. The personalized pharmaceutical composition for skin rejuvenation of claim 1, wherein said second group of variable active ingredients comprises up to 2% by weight of allantoin.

12. The personalized pharmaceutical composition for skin rejuvenation of claim 1, wherein said second group of variable active ingredients comprises up to 15% by weight of organic silicon.

13. The personalized pharmaceutical composition for skin rejuvenation of claim 1, wherein said second group of variable active ingredients comprises niacinamide.

14. The personalized pharmaceutical composition for skin rejuvenation of claim 13, wherein the niacinamide is present in a proportion of 4 to 6% by weight.

15. The personalized pharmaceutical composition for skin rejuvenation of claim 1, wherein said second group of variable active ingredients comprises vitamin F.

16. The personalized pharmaceutical composition for skin rejuvenation of claim 15, wherein said vitamin F is present in a proportion of 0.1 to 4% by weight.

17. The personalized pharmaceutical composition for skin rejuvenation of claim 1, wherein said second group of variable active ingredients comprises a cicatrizant.

18. The personalized pharmaceutical composition for skin rejuvenation of claim 17, wherein said cicatrizant is rosehip oil.

19. The personalized pharmaceutical composition for skin rejuvenation of claim 18, wherein said rosehip oil is present in a proportion of between 2 and 6% by weight.

20. The personalized pharmaceutical composition for skin rejuvenation of claim 1, wherein said second group of variable active ingredients comprises one or more hormones.

21. The personalized pharmaceutical composition for skin rejuvenation of claim 20, wherein said hormones are selected from the group consisting of oestrogen and progesterone, and wherein said hormones are present in a proportion of between 1 and 3% by weight.

22. The personalized pharmaceutical composition for skin rejuvenation of claim 1, wherein said second group of variable active ingredients comprises one or more topical antibiotics.

23. The personalized pharmaceutical composition for skin rejuvenation of claim 22, wherein said antibiotics are non-antagonistic antibiotics selected from the group consisting of sodium sulfacetamide, clindamycin, ciprofloxacin and erythromycin.

24. The personalized pharmaceutical composition for skin rejuvenation, of claim 1, wherein said second group of variable active ingredients comprises at least one coenzyme for energy production.

25. The personalized pharmaceutical composition for skin rejuvenation, of claim 24, wherein said coenzyme is selected from the group consisting of Co10 and NADH,

26. The personalized pharmaceutical composition for skin rejuvenation, of claim 1, wherein said second group of variable active ingredients comprises a preservative antioxidant.

27. The personalized pharmaceutical composition for skin rejuvenation of claim 1, wherein said second group of variable active ingredients comprises a moisturizing agent.

28. The personalized pharmaceutical composition for skin rejuvenation of claim 1 wherein the composition comprises suitable excipients to be formulated as a topical ointment.

29. A process for skin rejuvenation using the composition of claim 1 comprising the following steps:

(a) producing a controlled inflammation of a tissue;

(b) producing biostimulation of the tissue; and

(c) regenerating dermal and epidermal tissue,

wherein the dermal and epidermal tissue are rejuvenated.