LOW-OIL PHARMACEUTICAL EMULSION COMPOSITIONS COMPRISING PROGESTOGEN
First Claim
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1. A sterile, ready-to-use, pharmaceutical oil-in-water emulsion composition for parenteral administration comprising:
- 0.015 to 0.5% wt/vol progesterone;
0.5 to 10% wt/vol oil, wherein the oil comprises at least 85% wt/wt triglyceride;
0.0425 to 4.1% wt/vol phospholipid; and
80-99.4% wt/vol aqueous medium;
wherein the composition has an osmolality in the range of 200-1000 mOsm/kg.
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Abstract
Described are sterile, ready-to-use, pharmaceutical oil-in-water emulsion compositions for parenteral administration comprising:
- 0.015 to 0.5% wt/vol progesterone;
- 0.5 to 10% wt/vol oil, wherein the oil comprises at least 85% wt./wt. triglyceride;
- 0.0425 to 4.1% wt/vol phospholipid;
- 80-99.4% wt/vol aqueous medium;
wherein the composition has an osmolality in the range of 200-1000 mOsm/kg.
Also described are methods of making such compositions and method of using such compositions in therapeutic or prophylactic treatment, such as treatments comprising intravenous administration of the pharmaceutical composition.
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Citations
20 Claims
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1. A sterile, ready-to-use, pharmaceutical oil-in-water emulsion composition for parenteral administration comprising:
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0.015 to 0.5% wt/vol progesterone; 0.5 to 10% wt/vol oil, wherein the oil comprises at least 85% wt/wt triglyceride; 0.0425 to 4.1% wt/vol phospholipid; and 80-99.4% wt/vol aqueous medium; wherein the composition has an osmolality in the range of 200-1000 mOsm/kg. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20)
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Specification