SILVER/WATER, SILVER GELS AND SILVER-BASED COMPOSITIONS; AND METHODS FOR MAKING AND USING THE SAME

• US 20110262556A1
• Filed: 12/30/2005
• Published: 10/27/2011
• Est. Priority Date: 01/05/2005
• Status: Abandoned Application

• Current Assignee: American Silver LLC
• Original Assignee: American Silver LLC
• Inventors: Holladay, Robert J., Moeller, William, Brooks, Julian H.J., Mehta, Dillip, Roy, Rustum, Mortenson, Mark G.
• Application Number:
  US11/813,408
• Publication Number:
  US 20110262556A1
• Time in Patent Office: Days
• US Class Current: 424/616
• CPC Class Codes: A01N 2300/00 Combinations or mixtures of active ingredients covered by classes A01N27/00 - A01N65/48 with other active or formulation relevant ingredients, e.g. specific carrier materials or surfactants, covered by classes A01N25/00 - A01N65/48
• CPC Class Codes: A01N 25/04 Dispersions, emulsions, suspoemulsions, suspension concentrates or gels foams A01N25/16
• CPC Class Codes: A01N 59/00 Biocides, pest repellants or attractants, or plant growth regulators containing elements or inorganic compounds
• CPC Class Codes: A01N 59/16 Heavy metals; Compounds thereof
• CPC Class Codes: A61K 31/28 Compounds containing heavy metals
• CPC Class Codes: A61K 31/65 Tetracyclines
• CPC Class Codes: A61K 33/24 Heavy metals; Compounds thereof
• CPC Class Codes: A61K 33/243 Platinum; Compounds thereof
• CPC Class Codes: A61K 33/30 Zinc; Compounds thereof
• CPC Class Codes: A61K 33/34 Copper; Compounds thereof
• CPC Class Codes: A61K 33/38 Silver; Compounds thereof
• CPC Class Codes: A61K 45/06 Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
• CPC Class Codes: A61P 11/00 Drugs for disorders of the respiratory system
• CPC Class Codes: A61P 13/00 Drugs for disorders of the urinary system
• CPC Class Codes: A61P 15/00 Drugs for genital or sexual disorders for disorders of sex hormones A61P5/24; Contraceptives
• CPC Class Codes: A61P 15/02 for disorders of the vagina
• CPC Class Codes: A61P 17/00 Drugs for dermatological disorders
• CPC Class Codes: A61P 27/00 Drugs for disorders of the senses
• CPC Class Codes: A61P 31/00 Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
• CPC Class Codes: A61P 31/02 Local antiseptics
• CPC Class Codes: A61P 31/04 : Antibacterial agents
• CPC Class Codes: A61P 31/06 : for tuberculosis
• CPC Class Codes: A61P 31/10 : Antimycotics
• CPC Class Codes: A61P 31/12 : Antivirals
• CPC Class Codes: Y02A 50/30 : Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Abstract

We disclose a colorless composition comprising metal particles (e.g., silver nanoparticles) and water, wherein said particles comprise an interior of elemental metal (e.g., silver) and an exterior of metal oxide (e.g., one or more silver oxide(s)), wherein the metal nanoparticles are present in the water at a level of about 5-40 ppm, and wherein the composition manifests significant antimicrobial properties. Methods of use of the composition are described. The composition can be incorporated into a hydrogel with essentially no loss of antimicrobial properties. Various metal-containing compositions with unexpected biological efficacy are also disclosed.

Claims

1. A composition of silver in water comprising a total concentration of silver of between about 5 and 40 parts per million, said silver in the form of silver nanoparticles having an interior of elemental silver and a surface of at least one silver oxide, wherein a majority of the silver particles have a maximum diameter less than 0.015 micrometers, wherein a majority of the colloidal silver particles have a minimum diameter greater than 0.005 micrometers, and wherein the composition manifests antimicrobial properties.

2. The composition according to claim 1, further comprising hydrogen peroxide.

3. The composition according to claim 2, wherein the hydrogen peroxide concentration is between about 1% wght/v and about 3.0% wght/v.

4. The composition according to claim 1, further comprising EDTA.

5. The composition according to claim 4, wherein said EDTA comprises disodium EDTA.

6. The composition according to claim 1, wherein the composition comprises hydrogel formed by dissolving a hydrophilic polymer into the composition of silver in water.

7. The composition according to claim 6 formulated as an amorphous gel.

8. The composition according to claim 6 formulated as a solid gel sheet.

9. The composition according to claim 8, wherein the hydrophilic polymer is selected from the group consisting of gelatin, carbohydrate polymers and acrylic acid copolymers.

10. The composition according to claim 9, wherein the carbohydrate polymer comprises at least one polymer selected from the group consisting of cellulose derivatives, alginate, carrageenan, and plant gums.

11. A method of treating a disease selected from the group consisting of malaria, fungal infections of the skin, bacterial infections of the skin, vaginal infections, urinary tract infections, tonsillitis, pelvic inflammatory disease, pharyngitis, gonorrhea, conjunctivitis, otitis, respiratory tract infections, and nasal infections, comprising the step of administering an aliquot of the composition according to claim 1 to a person afflicted with the disease.

23. The method of claim 21, wherein said AgEDTA is added to the composition of claim 1 in an amount less than 20 ppm.

30. The method of claim 11, further comprising adding a selected antibiotic dose, said selected antibiotic dose being based on antibiotics having at least some known efficacy against said disease.

31. The composition of claim 1, further comprising at least one material selected from the group consisting of AgEDTA, silver EDDS, silver curcuminate, silver berberine, and silver tetracycline.

12. A method of treating a disease selected from the group consisting of malaria, fungal infections of the skin, bacterial infections of the skin, vaginal infections, urinary tract infections, tonsillitis, pelvic inflammatory disease, pharyngitis, gonorrhea, conjunctivitis, otitis, respiratory tract infections, and nasal infections, comprising the step of administering silver EDTA.

13. A method for eliminating microbes selected from the group consisting of Bacillus anthracis, Bacillus subtilis, Candida albicans, Mycobacteria bovis, Mycobacteria tuberculosis, Pseudomonas aeruginosa, Salmonella choleraesius, Staphylococcus aureus, Trichomonas vaginalis, and Yersinia pestis comprising exposing said microbes to silver EDTA.

14. The method of claim 13, wherein said exposing comprises ingesting silver EDTA.

15. A method for eliminating microbes selected from the group consisting of Bacillus anthracis, Bacillus subtilis, Candida albicans, Mycobacteria bovis, Mycobacteria tuberculosis, Pseudomonas aeruginosa, Salmonella choleraesius, Staphylococcus aureus, Trichomonas vaginalis, and Yersinia pestis comprising exposing said microbes to at least one composition selected from the group consisting of silver EDTA, silver EDDS, silver curcuminate, silver berberine, and silver tetracycline.

16. A method for delivering at least one metal to a biologic organism comprising attaching at least one metal selected from the group of metals consisting of silver, copper, zinc, platinum, titanium, and mixtures and alloys thereof to at least one clathrate to form a metal/clathrate structure, and exposing said biologic organism to said metal/clathrate structure.

17. The method of claim 16, wherein said clathrate comprises at least one kaolinite.

18. The method of claim 16, wherein said clathrate comprises at least one zeolite.

19. The method of claim 16, wherein said at least one metal comprises silver.

20. A prophylactic treatment for livestock comprising adding AgEDTA to at least one of the livestock feed and livestock water.

21. A prophylactic treatment for humans and animals comprising adding AgEDTA to anything that said human or animal ingests.

22. The method of claim 21, wherein said AgEDTA is added in an amount sufficient to prevent infections.

24. A method for treatment of human and animal infections comprising ingesting Ag EDTA in a quantity sufficient to ameliorate said infection.

25. A method for treatment of human or animal infection comprising ingesting at least one member selected from the group consisting of AgEDTA, silver EDDS, silver curcuminate, silver berberine, and silver tetracycline.

26. A method for treatment of human or animal skin surfaces comprising forming a paste or gel from at least one member selected from the group consisting of AgEDTA, silver EDDS, silver curcuminate, silver berberine, and silver tetracycline and contacting said paste or gel with said human or animal skin surface.

27. A gel or paste product comprising at least one member selected from the group consisting of AgEDTA, silver EDDS, silver curcuminate, silver berberine, and silver tetracycline.

28. A method of enhancing antibiotic dose efficacy comprising adding to said antibiotic dose at least one material selected from the group consisting of EDTA and AgEDTA.

29. The method of claim 28, wherein AgEDTA is added to said antibiotic dose.