OXIDIZABLE SPECIES AS AN INTERNAL REFERENCE IN CONTROL SOLUTIONS FOR BIOSENSORS
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Accused Products
Abstract
Testing of the performance of an electrochemical meter used to measure the presence of an analyte in a biological sample, particularly glucose in whole blood, includes introducing a control solution containing a predetermined amount of the analyte and a predetermined amount of an internal reference compound. The internal reference compound is selected such that it is oxidized at a potential greater than that used to oxidize the analyte, thereby making it possible to distinguish the control solution from a biological sample.
5 Citations
31 Claims
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1-21. -21. (canceled)
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22. A control solution for use in testing an electrochemical system for measuring the amount of an analyte in a sample, the control solution comprising:
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(a) a predetermined amount of said analyte; and (b) a predetermined amount of an internal reference compound, said internal reference compound being adapted to be oxidized at a potential higher than the potential required to oxidize said analyte, said predetermined amount of said internal reference compound being dependent upon said predetermined amount of analyte such the control solution is associated with a Differential Index (DI) sufficiently greater than 1, the DI being defined as DI=ihigh volt/ilow volt where;
ihigh volt is an electrical current resulting from the application of a first potential sufficient to oxidize said internal reference compound and said analyte, andilow volt is an electrical current resulting from the application of a second potential sufficient to measure oxidation of said analyte and insufficient to oxidize said internal reference compound. - View Dependent Claims (23, 24, 25, 26, 27, 28, 29, 30)
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31-37. -37. (canceled)
Specification