MEDICAL INSTRUMENTS AND TECHNIQUES FOR TREATING PULMONARY DISORDERS

• US 20110264090A1
• Filed: 11/16/2010
• Published: 10/27/2011
• Est. Priority Date: 03/27/1998
• Status: Active Grant

• Current Assignee: Canon Anelva Corporation (Canon Inc.), Tsunami MedTech, LLC
• Original Assignee: Tsunami MedTech, LLC
• Inventors: HOEY, Michael, SHADDUCK, John H.
• Granted Patent: US 8,187,269 B2
• Time in Patent Office: Days
• US Class Current: 606/41
• CPC Class Codes: A61B 17/32037 for removing obstructions from inner organs or blood vessels, e.g. for atherectomy
• CPC Class Codes: A61B 18/04 by heating by applying electromagnetic radiation A61B18/18; hyperthermia using electric or magnetic fields, radiation or ultrasound A61N
• CPC Class Codes: A61B 2017/00809 Lung operations
• CPC Class Codes: A61B 2018/00315 for treatment of particular body parts
• CPC Class Codes: A61B 2018/048 in gaseous form

Abstract

A surgical instrument for delivering energy to lung tissue, for example to cause lung volume reduction. In one embodiment, an elongated catheter has a handle portion that includes an interior chamber that is supplied with a biocompatible liquid media under pressure. An energy source delivers energy to the media to cause a liquid-to-vapor phase change within the interior chamber and ejects a flow of vapor media from the working end of the catheter. The delivery of energy and the flow of vapor are controlled by a computer controller to cause a selected pressure and selected volume of vapor to propagate to the extremities of the airways. Contemporaneously, the vapor undergoes a vapor-to-liquid phase transition which delivers large amount of energy to the airway tissue. The thermal energy delivered is equivalent to the heat of vaporization of the fluid media, which shrinks and collapses the treated airways. The treated tissue is the maintained in a collapsed state by means of aspiration for a short interval to enhance tissue remodeling. Thereafter, the patient'"'"'s wound healing response causes fibrosis and further remodeling to cause permanent lung volume reduction.

Claims

1. A method of applying energy to lung tissue in a lung to treat a lung disorder comprising:

generating a flow of vapor, and introducing a flow of vapor into lung wherein the vapor delivers thermal energy sufficient to modify lung tissue and

controlling the temperature of the heat of vaporization of the vapor.

2. The method of claim 1 wherein the introducing the flow of vapor includes the vapor undergoing a vapor-to-liquid phase transition thereby delivering thermal energy.

3. The method of claim 1 wherein introducing the flow of vapor includes delivering the heat of vaporization of the vapor to the lung tissue.

4. The method of claim 1 further comprising generating the flow of vapor by at least one of resistive heating means, radiofrequency (Rf) energy means, microwave energy means, photonic energy means, magnetic induction energy means, compression and decompression means, and ultrasonic energy means.

5. The method of claim 1, further comprising controlling at least one of the pressure of the flow of vapor, the volume of the flow of vapor and the duration of the flow of vapor.

7. The method of claim 1 wherein modifying lung tissue includes at least one of shrinkage, denaturation, damage, ablation, sealing, occlusion, an immune response and remodeling of lung tissue.

8. The method of claim 7 wherein the lung tissue includes at least one of bronchi, bronchioles, alveoli, parenchyma, diseased lung tissue, normal lung tissue, collagenous lung tissue and interalveolar collateral ventilation tissue.

9. The method of claim 1 wherein the flow of vapor is introduced within a targeted airway.

10. The method of claim 9 wherein introducing the flow of vapor includes pressurizing the flow of vapor sufficiently to extend the flow to airway extremities.

11. The method of claim 1 wherein introducing the flow of vapor is performed over an interval timed to substantially prevent conductive heat transfer to body structure external to a targeted airway.

12. The method of claim 1 wherein introducing the flow of vapor includes providing a vapor having a mass average temperature that is lower than about 100°

C.

13. The method of claim 12 wherein the mass average temperature is provided by introducing a selected media into the flow of vapor, the selected media consisting of at least one of a gas, a liquid or particulate matter.

14. The method of claim 13 wherein the selected media includes at least one of depressurized CO₂, N₂, O₂ or H₂O.

15. The method of claim 1 wherein generating the flow of vapor includes generating the vapor or at least one of water, saline and alcohol.

16. The method of claim 1 wherein introducing the flow of vapor includes introducing at least one substance with the vapor.

17. The method of claim 1 including introducing at least one active agent with the vapor.

18. The method of claim 17 wherein the active agent is selected from a group consisting of an anesthetic an antibiotic, a toxin, a sclerosing agent, alcohol, and an enhancing media.

24. The method of claim 1 further comprising the step of imaging the flow of vapor.

25. The method of claim 1 wherein introducing the flow of vapor is preceded by the step of expanding an expansion structure in a proximal portion of a targeted airway for controlling the direction of the flow of vapor.

26. The method of claim 25 wherein the step of expanding the expansion structure includes evacuating air from the airway distal to the expansion structure prior to introducing the flow of vapor.

27. The method of claim 25 further comprising the step of applying negative pressure to the targeted airway after terminating the flow of vapor.

28. The method of claim 27 wherein the step of applying negative pressure is performed for an interval sufficient for tissue cooling.

29. The method of claim 27 wherein the step of applying negative pressure is performed for an interval sufficient for tissue remodeling.

30. The method of claim 1 wherein the heat of vaporization of the vapor is above about 80°

C.

31. The method of claim 1 wherein the heat of vaporization of the vapor is at least about 500 calories per gram.

32. The method of claim 1 further comprising coupling electrical energy to the flow of vapor.

33. The method of claim 32 wherein the flow of vapor includes a plasma.

34. The method of claim 1 wherein the flow of vapor is introduced interstitially.

6. (canceled)

19-23. -23. (canceled)

35-63. -63. (canceled)