MEDICAL IMPLANT INCLUDING A 3D MESH OF OXIDIZED CELLULOSE AND A COLLAGEN SPONGE

• US 20110264119A1
• Filed: 11/06/2009
• Published: 10/27/2011
• Est. Priority Date: 11/07/2008
• Status: Active Grant

• Current Assignee: Sofradim Production
• Original Assignee: Sofradim Production
• Inventors: Ladet, Sébastien, Bayon, Yves, Lefranc, Olivier, Gravagna, Philippe
• Granted Patent: US 9,119,898 B2
• Time in Patent Office: Days
• US Class Current: 606/151
• CPC Class Codes: A61L 27/20 Polysaccharides
• CPC Class Codes: A61L 27/24 Collagen
• CPC Class Codes: A61L 27/56 Porous materials, e.g. foams or sponges
• CPC Class Codes: C08L 1/02 Cellulose; Modified cellulose

Abstract

The present invention relates to A bioresorbable implant comprising: a bioresorbable porous layer including a biopolymer foam and defining first pores, a bioresorbable porous three-dimensional mesh made from a microbial cellulose and defining second pores, wherein the bioresorbable porous layer is disposed in the bioresorbable porous three-dimensional mesh. The invention also relates to a method of making a bioresorbable implant.

Claims

1-16. -16. (canceled)

17. A bioresorbable implant comprising:

a bioresorbable porous layer including a biopolymer foam and defining first pores, a bioresorbable porous three-dimensional mesh made from a microbial cellulose and defining second pores, wherein the bioresorbable porous layer is disposed in the bioresorbable porous three-dimensional mesh.

18. The bioresorbable implant of claim 17, wherein the first and second pores are at least partially interconnected with one another.

19. The bioresorbable implant of claim 17, further comprising a non-porous layer.

20. The bioresorbable implant of claim 17, wherein the microbial cellulose is derived from Acetobacter xylinum as wet pellicles or films.

21. The bioresorbable implant of claim 17, wherein the microbial cellulose is oxidized.

22. The bioresorbable implant of claim 17, wherein the biopolymer foam comprises pores having a size of from about 10 μ

m to about 500 μ

m.

23. The bioresorbable implant of claim 17, wherein the biopolymer foam comprises a natural, bioresorbable material.

24. The bioresorbable implant of claim 17, wherein the biopolymer foam comprises collagen.

25. The bioresorbable implant of claim 17, wherein the biopolymer foam is from about 0.2 to about 1.5 cm thick.

26. The bioresorbable implant of claim 17, wherein the porous layer has a density of from about 1 mg collagen/cm² to about 200 mg collagen/cm².

27. The bioresorbable implant of claim 17, further comprising a bioactive agent.

28. A method of making a bioresorbable implant, comprising:

adding a solution of bioresorbable biopolymer to a bioresorbable porous three-dimensional mesh made from a microbial cellulose, lyophilizing the solution to create a bioresorbable foam layer in the bioresorbable porous three-dimensional mesh.

29. The method of claim 28, wherein the solution of bioresorbable biopolymer comprises an aqueous acid solution or suspension of collagen at a concentration of about 2 g/l to about 100 g/l.

30. The method of claim 28, wherein the biopolymer foam layer is cross-linked.

31. The method of claim 28, further comprising the step of applying a non porous layer to the bioresorbable porous three-dimensional mesh filled with the bioresorbable porous layer.

32. The method of claim 31, wherein the non porous layer comprises a collagenic constituent.