Charged Particle Beam Generator, Charged Particle Irradiation System, Method for Operating Charged Particle Beam Generator and Method for Operating Charged Particle Irradiation System

• US 20110266981A1
• Filed: 04/27/2011
• Published: 11/03/2011
• Est. Priority Date: 04/30/2010
• Status: Active Grant

• Current Assignee: Hitachi, Ltd.
• Original Assignee: Hitachi, Ltd.
• Inventors: UMEZAWA, Masumi, Hojo, Yoshifumi
• Granted Patent: US 8,742,699 B2
• Time in Patent Office: Days
• US Class Current: 315/506
• CPC Class Codes: A61N 2005/1087 Ions; Protons
• CPC Class Codes: G21K 1/093 by magnetic means
• CPC Class Codes: G21K 5/04 with beam-forming means
• CPC Class Codes: H05H 13/04 Synchrotrons
• CPC Class Codes: H05H 7/10 Arrangements for ejecting particles from orbits
• CPC Class Codes: H05H 9/00 Linear accelerators

Abstract

A charged particle beam generator, a charged particle irradiation system, a method for operating the charged particle beam generator and a method for operating the charged particle irradiation system, which allow a charged particle beam to be injected into a circular accelerator at an arbitrary timing and can reduce an irradiation time and a time for a therapy, are provided while maintaining the lower limit of an operation cycle of a linear accelerator. An accelerator control device controls an operation of a synchrotron on the basis of a beam extraction request signal transmitted from a beam utilization system control device. A control device generates a timing signal notifying the linear accelerator of an injection timing of a next operation cycle of the synchrotron after completion of an extraction process performed by the synchrotron, changes an operation timing of the linear accelerator so that the operation timing of the linear accelerator matches the injection timing.

Claims

1. A method for operating a charged particle beam generator that includes a linear accelerator and a circular accelerator,

wherein the linear accelerator operates in a predetermined operation cycle on the basis of a radiofrequency power supply for applying a pulse voltage for acceleration, and accelerates, at an operation timing based on the operation cycle, charged particles extracted from an ion source so as to cause a charged particle beam to be extracted from the linear accelerator;

and

wherein the circular accelerator operates in an operation cycle including a process of causing the charged particle beam to be injected into the circular accelerator, a process of accelerating the charged particle beam, a process of causing the charged particle beam to be extracted from the circular accelerator and a process of decelerating the charged particle beam, causes the charged particle beam accelerated by the linear accelerator to be injected into the circular accelerator at a predetermined timing, and causes the accelerated charged particle beam to be extracted from the circular accelerator,

the method comprising the step of changing the operation timing of the linear accelerator after completion of the process of causing the charged particle beam to be extracted from the circular accelerator in the operation cycle of the circular accelerator so that the operation cycle of the linear accelerator temporarily increases and the operation timing of the linear accelerator matches an injection timing of the next operation cycle of the circular accelerator.

2. The method according to claim 1,

wherein after the completion of the process of causing the charged particle beam to be extracted from the circular accelerator in the operation cycle of the circular accelerator, a timing signal that notifies the linear accelerator of the injection timing of the next operation cycle of the circular accelerator is generated, and the operation timing of the linear accelerator is changed on the basis of the timing signal so that the operation cycle of the linear accelerator temporarily increases.

3. The method according to claim 2,

wherein the timing signal is set so that a time period that ranges from the time of the generation of the timing signal to the injection timing of the next operation cycle of the circular accelerator is equal to an integral multiple of the operation cycle of the linear accelerator, and

wherein the operation timing of the linear accelerator is generated when one operation cycle of the linear accelerator elapses after the generation of the timing signal.

4. The method according to claim 2,

wherein the timing signal is set so that a time period that ranges from the time of the generation of the timing signal to the injection timing of the next operation cycle of the circular accelerator is equal to the sum of an integral multiple of the operation cycle of the linear accelerator and a certain time period that is shorter than the operation cycle of the linear accelerator,

wherein when the operation timing of the linear accelerator is immediately before the generation of the timing signal, and the sum of the certain time period and a time period that ranges from the operation timing of the linear accelerator to the time of the generation of the timing signal is larger than one operation cycle of the linear accelerator, the operation timing of the linear accelerator is generated when the certain time period elapses after the generation of the timing signal, and

wherein when the operation timing of the linear accelerator is immediately before the generation of the timing signal, and the sum of the certain time period and a time period that ranges from the operation timing of the linear accelerator to the time of the generation of the timing signal is not larger than one operation cycle of the linear accelerator, the operation timing of the linear accelerator is generated when the sum of the certain time period and one operation cycle of the linear accelerator elapses after the generation of the timing signal.

5. A method for operating a charged particle irradiation system that includes a linear accelerator, a circular accelerator, and an irradiation device,

wherein the linear accelerator operates in a predetermined operation cycle on the basis of a radiofrequency power supply for applying a pulse voltage for acceleration, and accelerates, at an operation timing based on the operation cycle, charged particles extracted from an ion source so as to cause a charged particle beam to be extracted from the linear accelerator,

wherein the circular accelerator operates in an operation cycle including a process of causing the charged particle beam to be injected into the circular accelerator, a process of accelerating the charged particle beam, a process of causing the charged particle beam to be extracted from the circular accelerator and a process of decelerating the charged particle beam, causes the charged particle beam accelerated by the linear accelerator to be injected into the circular accelerator at a predetermined timing, and causes the accelerated charged particle beam to be extracted from the circular accelerator, and

wherein the irradiation device radiates the charged particle beam extracted from the circular accelerator, the method comprising the steps of:

controlling an extractor of the circular accelerator in the process of causing the charged particle beam to be extracted from the circular accelerator in the operation cycle of the circular accelerator so that the charged particle beam is extracted from the circular accelerator only for a time period requested from the irradiation device; and

changing the operation timing of the linear accelerator after the process of causing the charged particle beam to be extracted from the circular accelerator in the operation cycle of the circular accelerator is completed by the control of the extractor so that the operation cycle of the linear accelerator temporarily increases and the operation timing of the linear accelerator matches an injection timing of the next operation cycle of the circular accelerator.

6. A method for operating a charged particle irradiation system that includes a linear accelerator, a circular accelerator, and irradiation device,

wherein the linear accelerator operates in a predetermined operation cycle on the basis of a radiofrequency power supply for applying a pulse voltage for acceleration, and accelerates, at an operation timing based on the operation cycle, charged particles extracted from an ion source so as to cause a charged particle beam to be extracted from the linear accelerator,

wherein the circular accelerator operates in an operation cycle including a process of causing the charged particle beam to be injected into the circular accelerator, a process of accelerating the charged particle beam, a process of causing the charged particle beam to be extracted from the circular accelerator and a process of decelerating the charged particle beam, causes the charged particle beam accelerated by the linear accelerator to be injected into the circular accelerator at a predetermined timing, and causes the accelerated charged particle beam to be extracted from the circular accelerator, and

wherein the irradiation device has a scanning magnet for deflecting the charged particle beam extracted from the circular accelerator so as to scan a target with the charged particle beam and irradiates the target with the charged particle beam that has passed through the scanning magnet, the method comprising the steps of:

controlling a excitation current to be applied to the scanning magnet, scanning, with the charged particle beam, one of a plurality of layers into which the target to be irradiated with the charged particle beam is divided in a depth direction; and

after completion of the scanning of the one layer with the charged particle beam, outputting an energy switch request indicating a request for a change in the energy of the charged particle beam to be extracted from the circular accelerator in order to scan another one of the layers with the charged particle beam; and

changing the operation timing of the linear accelerator after completion of the process of causing the charged particle beam to be extracted from the circular accelerator in the operation cycle of the circular accelerator so that the operation cycle of the linear accelerator temporarily increases and the operation timing of the linear accelerator matches an injection timing of the next operation cycle of the circular accelerator in order to change the operation cycle of the circular accelerator to the next operation cycle on the basis of the energy switch request.

7. A method for operating a charged particle irradiation system that includes a linear accelerator, a circular accelerator, and an irradiation device,

wherein the linear accelerator operates in a predetermined operation cycle on the basis of a radiofrequency power supply for applying a pulse voltage for acceleration, and accelerates, at an operation timing based on the operation cycle, charged particles extracted from an ion source so as to cause a charged particle beam to be extracted from the linear accelerator,

wherein the circular accelerator operates in an operation cycle including a process of causing the charged particle beam to be injected into the circular accelerator, a process of accelerating the charged particle beam, a process of causing the charged particle beam to be extracted from the circular accelerator and a process of decelerating the charged particle beam, causes the charged particle beam accelerated by the linear accelerator to be injected into the circular accelerator at a predetermined timing, and causes the accelerated charged particle beam to be extracted from the circular accelerator, and

wherein the irradiation device has a scanning magnet for deflecting the charged particle beam extracted from the circular accelerator so as to scan a target with the charged particle beam and irradiates the target with the charged particle beam that has passed through the scanning magnet, the method comprising the steps of:

controlling an excitation current to be applied to the scanning magnet, scanning a target with the charged particle beam, when charged particles that are stored in the circular accelerator are depleted during the scanning with the charged particle beam or when a time for irradiation that can be performed during one cycle of the circular accelerator is not sufficient and elapses during the scanning with the charged particle beam, stopping the process of causing the charged particle beam to be extracted from the circular accelerator in the operation cycle of the circular accelerator, and outputting an operational pattern transition request indicating a request for a transition to an operational pattern of the next operation cycle; and

changing the operation timing of the linear accelerator after completion of the process of causing the charged particle beam to be extracted from the circular accelerator in the operation cycle of the circular accelerator so that the operation cycle of the linear accelerator temporarily increases and the operation timing of the linear accelerator matches an injection timing of the next operation cycle of the circular accelerator in order to change the operation cycle of the circular accelerator to the next operation cycle on the basis of the operational pattern transition request.

8. A method for operating a charged particle irradiation system that includes a linear accelerator, a circular accelerator, and an irradiation device,

wherein the linear accelerator operates in a predetermined operation cycle on the basis of a radiofrequency power supply for applying a pulse voltage for acceleration, and accelerates, at an operation timing based on the operation cycle, charged particles extracted from an ion source so as to cause a charged particle beam to be extracted from the linear accelerator,

wherein the circular accelerator operates in an operation cycle including a process of causing the charged particle beam to be injected into the circular accelerator, a process of accelerating the charged particle beam, a process of causing the charged particle beam to be extracted from the circular accelerator and a process of decelerating the charged particle beam, causes the charged particle beam accelerated by the linear accelerator to be injected into the circular accelerator at a predetermined timing, and causes the accelerated charged particle beam to be extracted from the circular accelerator, and

wherein the irradiation device temporally or spatially forms the charged particle beam extracted from the circular accelerator and irradiates a target with the charged particle beam so that the shape of the target matches a region to be irradiated with the charged particle beam, the method comprising the steps of:

setting, on the basis of a signal obtained by a detection of a movement of the target to be irradiated, a timing of a time period for which the target can be irradiated, and outputting a beam request that indicates a request to extract the charged particle beam only for the time period; and

changing the operation timing of the linear accelerator after completion of the process of causing the charged particle beam to be extracted from the circular accelerator in the operation cycle of the circular accelerator so that the operation cycle of the linear accelerator temporarily increases and the operation timing of the linear accelerator matches an injection timing of the next operation cycle of the circular accelerator in order to change the operation cycle of the circular accelerator to the next operation cycle on the basis of the beam request.

9. A charged particle beam generator comprising:

a linear accelerator that operates in a predetermined operation cycle on the basis of a radiofrequency power supply for applying a pulse voltage for acceleration, and accelerates, at an operation timing based on the operation cycle, charged particles extracted from an ion source so as to cause a charged particle beam to be extracted from the linear accelerator;

a circular accelerator that operates in an operation cycle including a process of causing the charged particle beam to be injected into the circular accelerator, a process of accelerating the charged particle beam, a process of causing the charged particle beam to be extracted from the circular accelerator and a process of decelerating the charged particle beam, causes the charged particle beam accelerated by the linear accelerator to be injected into the circular accelerator at a predetermined timing and causes the accelerated charged particle beam to be extracted from the circular accelerator; and

a control device that changes the operation timing of the linear accelerator after completion of the process of causing the charged particle beam to be extracted from the circular accelerator in the operation cycle of the circular accelerator so that the operation cycle of the linear accelerator temporarily increases and the operation timing of the linear accelerator matches an injection timing of the next operation cycle of the circular accelerator.

10. The charged particle beam generator according to claim 9,

wherein the control device generates a timing signal notifying the linear accelerator of the injection timing of the next operation cycle of the circular accelerator after completion of the process of causing the charged particle beam to be extracted from the circular accelerator in the operation cycle of the circular accelerator, and changes the operation timing of the linear accelerator so that the operation cycle of the linear accelerator temporarily increases.

11. The charged particle beam generator according to claim 10,

wherein the control device sets the timing signal so that a time period that ranges from the time of the generation of the timing signal to the injection timing of the next operation cycle of the circular accelerator is equal to an integral multiple of the operation cycle of the linear accelerator, and

wherein the control device generates the operation timing of the linear accelerator when one operation cycle of the linear accelerator elapses after the generation of the timing signal.

12. The charged particle beam generator according to claim 10,

wherein the control device sets the timing signal so that a time period that ranges from the time of the generation of the timing signal to the injection timing of the next operation cycle of the circular accelerator is equal to the sum of an integral multiple of the operation cycle of the linear accelerator and a certain time period that is shorter than the operation cycle of the linear accelerator,

wherein when the operation timing of the linear accelerator is immediately before the generation of the timing signal, and the sum of the certain time period and a time period ranging from the operation timing of the linear accelerator to the time of the generation of the timing signal is larger than one operation cycle of the linear accelerator, the control device generates the operation timing of the linear accelerator when the certain time period elapses after the generation of the timing signal, and

wherein the operation timing of the linear accelerator is immediately before the generation of the timing signal, and the sum of the certain time period and a time period ranging from the operation timing of the linear accelerator to the time of the generation of the timing signal is not larger than one operation cycle of the linear accelerator, the control device sets the operation timing of the linear accelerator to the time when the sum of one operation cycle of the linear accelerator and the certain time period elapses after the generation of the timing signal.

13. The charged particle beam generator according to claim 9,

wherein the control device includes:

a storage device that stores an injection pretrigger signal timing notifying the linear accelerator of the injection timing of the next operation cycle of the circular accelerator and timings related to an operational pattern including the process of causing the charged particle beam to be injected into the circular accelerator, the process of accelerating the charged particle beam, the process of causing the charged particle beam to be extracted from the circular accelerator and the process of decelerating the charged particle beam;

a timing control device that receives a request to update the operational pattern and receives information on the timings stored in the storage device;

a constant cycle generator that generates a basic operation cycle of the linear accelerator; and

a radiofrequency device timing generator that adjusts the basic operation cycle received from the constant cycle setting device on the basis of the injection pretrigger signal timing generated by the timing control device, and generates the operation timing of the linear accelerator.

14. A charged particle irradiation system comprising:

a linear accelerator that operates in a predetermined operation cycle on the basis of a radiofrequency power supply for applying a pulse voltage for acceleration, and accelerates, at an operation timing based on the operation cycle, charged particles extracted from an ion source so as to causes a charged particle beam to be extracted from the linear accelerator;

a circular accelerator that operates in an operation cycle including a process of causing the charged particle beam to be injected into the circular accelerator, a process of accelerating the charged particle beam, a process of causing the charged particle beam to be extracted from the circular accelerator, and a process of decelerating the charged particle beam, causes the charged particle beam accelerated by the linear accelerator to be injected into the circular accelerator at a predetermined timing, accelerates the charged particle beam, and causes the accelerated charged particle beam to be extracted from the circular accelerator;

an irradiation device that radiates the charged particle beam extracted from the circular accelerator;

a first control device that controls an extractor of the circular accelerator in the process of causing the charged particle beam to be extracted from the circular accelerator in the operation cycle of the circular accelerator so that the charged particle beam is extracted from the circular accelerator only for a time period requested from the irradiation device; and

a second control device that changes the operation timing of the linear accelerator after the process of causing the charged particle beam to be extracted from the circular accelerator is completed by the control of the extractor in the operation cycle of the circular accelerator so that the operation cycle of the linear accelerator temporarily increases and the operation timing of the linear accelerator matches an injection timing of the next operation cycle of the circular accelerator.

18. The charged particle irradiation system according to claim 14,

wherein the second control device sets the timing signal so that a time period that ranges from the time of the generation of the timing signal to the injection timing of the next operation cycle of the circular accelerator is equal to an integral multiple of the operation cycle of the linear accelerator, and

wherein the second control device generates the operation timing of the linear accelerator when one operation cycle of the linear accelerator elapses after the generation of the timing signal.

19. The charged particle irradiation system according to claim 14,

wherein the second control device sets the timing signal so that a time period that ranges from the time of the generation of the timing signal to the injection timing of the next operation cycle of the circular accelerator is equal to the sum of an integral multiple of the operation cycle of the linear accelerator and a certain time period that is shorter than the operation cycle of the linear accelerator,

wherein when the operation timing of the linear accelerator is immediately before the generation of the timing signal, and the sum of the certain time period and a time period ranging from the operation timing of the linear accelerator to the time of the generation of the timing signal is larger than one operation cycle of the linear accelerator, the second control device generates the operation timing of the linear accelerator when the certain time period elapses after the generation of the timing signal, and

wherein when the operation timing of the linear accelerator is immediately before the generation of the timing signal, and the sum of the certain time period and the time period ranging from the operation timing of the linear accelerator to the time of the generation of the timing signal is not larger than one operation cycle of the linear accelerator, the second control device generates the operation timing of the linear accelerator when the sum of one operation cycle of the linear accelerator and the certain time period elapses after the generation of the timing signal.

15. A charged particle irradiation system comprising:

a linear accelerator that operates in a predetermined operation cycle on the basis of a radiofrequency power supply for applying a pulse voltage for acceleration, and accelerates, at an operation timing based on the operation cycle, charged particles extracted from an ion source so as to causes a charged particle beam to be extracted from the linear accelerator;

a circular accelerator that operates in an operation cycle including a process of causing the charged particle beam to be injected into the circular accelerator, a process of accelerating the charged particle beam, a process of causing the charged particle beam to be extracted from the circular accelerator, and a process of decelerating the charged particle beam, causes the charged particle beam accelerated by the linear accelerator to be injected into the circular accelerator at a predetermined timing, accelerates the charged particle beam, and causes the accelerated charged particle beam to be extracted from the circular accelerator;

an irradiation device that has a scanning magnet for deflecting the charged particle beam extracted from the circular accelerator so as to scan a target with the charged particle beam and irradiates the target with the charged particle beam that has passed through the scanning magnet;

a first control device that controls a excitation current to be applied to the scanning magnet, scans, with the charged particle beam, one of a plurality of layers, into which the target to be irradiated with the charged particle beam is divided in a depth direction, and outputs, after completion of the scanning of the one layer with the charged particle beam, an energy switch request indicating a request for a change in the energy of the charged particle beam to be extracted from the circular accelerator in order to scan another one of the layers with the charged particle beam; and

a second control device that changes the operation timing of the linear accelerator after completion of the process of causing the charged particle beam to be extracted from the circular accelerator in the operation cycle of the circular accelerator so that the operation cycle of the linear accelerator temporarily increases and the operation timing of the linear accelerator matches the injection timing of the next operation cycle of the circular accelerator in order to change the operation cycle of the circular accelerator to the next operation cycle on the basis of the energy switch request.

16. A charged particle irradiation system comprising:

a linear accelerator that operates in a predetermined operation cycle on the basis of a radiofrequency power supply for applying a pulse voltage for acceleration, and accelerates, at an operation timing based on the operation cycle, charged particles extracted from an ion source so as to causes a charged particle beam to be extracted from the linear accelerator;

a circular accelerator that operates in an operation cycle including a process of causing the charged particle beam to be injected into the circular accelerator, a process of accelerating the charged particle beam, a process of causing the charged particle beam to be extracted from the circular accelerator and a process of decelerating the charged particle beam, causes the charged particle beam accelerated by the linear accelerator to be injected into the circular accelerator at a predetermined timing, accelerates the charged particle beam, and causes the accelerated charged particle beam to be extracted from the circular accelerator;

an irradiation device that has a scanning magnet for deflecting the charged particle beam extracted from the circular accelerator so as to scan a target with the charged particle beam and irradiates the target with the charged particle beam that has passed through the scanning magnet;

a first control device that controls an excitation current to be applied to the scanning magnet and scans the target with the charged particle beam, and that stops the process of causing the charged particle beam to be extracted from the circular accelerator in the operation cycle of the circular accelerator and outputs an operational pattern transition request indicating a request for a transition to an operational pattern of the next operation cycle when charged particles that are stored in the circular accelerator are depleted during the scanning with the charged particle beam or when a time for irradiation that can be performed during one cycle of the circular accelerator is not sufficient and elapses during the scanning with the charged particle beam; and

a second control device that changes the operation timing of the linear accelerator after completion of the process of causing the charged particle beam to be extracted from the circular accelerator in the operation cycle of the circular accelerator so that the operation cycle of the linear accelerator temporarily increases and the operation timing of the linear accelerator matches the injection timing of the next operation cycle of the circular accelerator in order to change the operation cycle of the circular accelerator to the next operation cycle on the basis of the operational pattern transition request.

17. A charged particle irradiation system comprising:

a linear accelerator that operates in a predetermined operation cycle on the basis of a radiofrequency power supply for applying a pulse voltage for acceleration, and accelerates, at an operation timing based on the operation cycle, charged particles extracted from an ion source so as to causes a charged particle beam to be extracted from the linear accelerator;

a circular accelerator that operates in an operation cycle including a process of causing the charged particle beam to be injected into the circular accelerator, a process of accelerating the charged particle beam, a process of causing the charged particle beam to be extracted from the circular accelerator, and a process of decelerating the charged particle beam, causes the charged particle beam accelerated by the linear accelerator to be injected into the circular accelerator at a predetermined timing, accelerates the charged particle beam, and causes the accelerated charged particle beam to be extracted from the circular accelerator;

an irradiation device that temporally or spatially forms the charged particle beam extracted from the circular accelerator and irradiates a target with the charged particle beam so that the shape of the target matches a region to be irradiated with the charged particle beam;

a first control device that sets, on the basis of a signal obtained by a detection of a movement of the target to be irradiated, a timing of a time period for which the target can be irradiated, and that outputs a beam request indicating a request to extract the charged particle beam only for the time period for which the target can be irradiated; and

a second control device that changes the operation timing of the linear accelerator after completion of the process of causing the charged particle beam to be extracted from the circular accelerator in the operation cycle of the circular accelerator so that the operation cycle of the linear accelerator temporarily increases and the operation timing of the linear accelerator matches an injection timing of the next operation cycle of the circular accelerator in order to change the operation cycle of the circular accelerator to the next operation cycle on the basis of the beam request.