STXBP1 AS PSYCHIATRIC BIOMARKER IN MURINE MODEL SYSTEM AND THEIR USES
First Claim
1. A transgenic rodent having a polynucleotide encoding an STXBP1 polypeptide, which polynucleotide is operably linked to a brain-specific promoter, wherein said transgenic rodent has greater than wild-type expression of the STXBP1 polypeptide in at least one brain region selected from the group consisting of cortex, striatum, hippocampus, and cerebellum.
4 Assignments
0 Petitions
Accused Products
Abstract
A non-human transgenic animal having a polynucleotide encoding an STXBP1 polypeptide, which polynucleotide is operably linked to a promoter, wherein said transgenic animal has greater than wild-type expression of the STXBP1 polypeptide in at least one brain region, as well as related vectors, methods of producing transgenic animals, in vitro and in vivo screening methods for potential therapeutic agents, and methods for treating and diagnosing neuropsychiatric illness are disclosed.
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Citations
48 Claims
- 1. A transgenic rodent having a polynucleotide encoding an STXBP1 polypeptide, which polynucleotide is operably linked to a brain-specific promoter, wherein said transgenic rodent has greater than wild-type expression of the STXBP1 polypeptide in at least one brain region selected from the group consisting of cortex, striatum, hippocampus, and cerebellum.
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4-5. -5. (canceled)
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8. (canceled)
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10. (canceled)
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12-16. -16. (canceled)
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18-24. -24. (canceled)
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28-39. -39. (canceled)
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42. (canceled)
Specification