MINIMALLY INVASIVE DETERMINATION OF COLLATERAL VENTILATION IN LUNGS

• US 20110270116A1
• Filed: 10/27/2010
• Published: 11/03/2011
• Est. Priority Date: 12/07/2005
• Status: Active Grant

• Current Assignee: Pulmonx Corp.
• Original Assignee: Pulmonx Corp.
• Inventors: Aljuri, Nikolai, Freitag, Lutz
• Granted Patent: US 8,523,782 B2
• Time in Patent Office: Days
• US Class Current: 600/538
• CPC Class Codes: A61B 5/087 Measuring breath flow
• CPC Class Codes: A61B 5/097 Devices for facilitating collection of breath or for directing breath into or through measuring devices
• CPC Class Codes: A61B 5/6852 Catheters

Abstract

Minimally invasive methods, systems and devices are provided for assessing collateral ventilation in the lungs. In particular, collateral ventilation of a target compartment within a lung of a patient is assessed by advancement of a catheter through the tracheobronchial tree to a feeding airway of the target compartment. The feeding airway is occluded by the catheter and the opening and closing of a one-way valve coupled with the catheter is observed. If the valve ceases opening and closing over time, this may indicate that significant collateral ventilation into the target compartment is absent. If the valve continues to open and close over time, significant collateral ventilation into the compartment may be present. Based on the collateral ventilation assessment, a treatment plan may be generated.

Claims

1. A method for determining presence or absence of collateral ventilation between lung compartments in a patient, the method comprising:

introducing a catheter transtracheally to an airway feeding into a target lung compartment;

deploying an occlusion member on the catheter in the airway to prevent inhaled air from traveling into the target lung compartment through the airway while allowing exhaled air to leave the target lung compartment through a lumen of the catheter;

allowing the patient to breathe;

observing opening and closing of a one-way valve coupled with a proximal portion of the catheter and in fluid communication with the catheter lumen, wherein the one-way valve is located outside the patient; and

determining the presence or absence of collateral ventilation into the target lung compartment from one or more adjacent lung compartments, based on the observed opening and closing of the one-way valve over time.

2. A method as in claim 1, wherein the observing step is performed over a period of time sufficient to allow breathing by the patient to significantly empty the target lung compartment of air if there is no collateral ventilation into the target lung compartment.

3. A method as in claim 2, wherein determining comprises deciding that significant collateral ventilation into the target lung compartment is absent if the one-way valve stops opening and closing during the period of time.

4. A method as in claim 2, wherein determining comprises deciding that significant collateral ventilation into the target lung compartment is present if the one-way valve continues opening and closing throughout the period of time.

5. A method as in claim 2, wherein observing comprises viewing the opening and closing via a video camera aimed at the valve and a video monitor displaying the video image captured by the camera.

6. A method as in claim 1, further comprising measuring at least one parameter via the catheter.

7. A method as in claim 6, wherein measuring the parameter comprises measuring collateral resistance.

8. A system for detecting collateral ventilation into a lung compartment in a patient, the system comprising:

a catheter having a lumen and adapted to be introduced transtracheally to a bronchus leading to a target lung compartment;

an occlusion member on a distal region of the catheter, said occlusion member being adapted to selectively occlude the bronchus; and

a one-way valve coupled with a proximal region of the catheter and in fluid communication with the lumen,

wherein the occlusion member, when deployed in the bronchus, prevents air from being inhaled into the target lung compartment through the bronchus, wherein the catheter allows air exhaled from the target lung compartment to pass through the lumen and the one-way valve, and wherein the catheter has sufficient overall length so that the one-way valve is located outside the patient during use.

9. A system as in claim 8, further comprising a video camera adapted to capture video images of the one-way valve.

10. A system as in claim 9, wherein the video camera comprises a USB camera.

11. A system as in claim 9, wherein the video camera is coupled with the proximal region of the catheter.

12. A system as in claim 11, wherein the video camera is coupled with a housing member, wherein the one-way valve is coupled with the housing member, and wherein the proximal region of the catheter is coupled with the housing member.

13. A system as in claim 9, further comprising a video monitor for displaying the video images captured by the video camera.

14. A system as in claim 8, wherein the one-way valve is removably coupled with the catheter.

15. A system as in claim 14, wherein the one-way valve comprises an endobronchial valve device.

16. A system as in claim 8, wherein the one-way valve is housed inside a housing member that is removably coupled with the proximal region of the catheter.

17. A system as in claim 8, further comprising a filter coupled with the catheter to filter exhaled air traveling through the catheter to the valve, wherein at least a portion of the catheter distal to the filter is removable from the system, so that the valve may be used in multiple patients without fear of contamination.