Injector having a displaceable stopper part

• US 20110270167A1
• Filed: 07/05/2011
• Published: 11/03/2011
• Est. Priority Date: 01/13/2009
• Status: Active Grant

• Current Assignee: LTS Lohmann Therapie-Systeme AG
• Original Assignee: LTS Lohmann Therapie-Systeme AG
• Inventors: Matusch, Rudolf
• Granted Patent: US 8,545,441 B2
• Time in Patent Office: Days
• US Class Current: 604/89
• CPC Class Codes: A61J 1/2041 having removable plugs
• CPC Class Codes: A61J 1/2051 having tap means, e.g. tap means activated by sliding
• CPC Class Codes: A61J 1/2096 Combination of a vial and a syringe for transferring or mixing their contents
• CPC Class Codes: A61M 2005/2013 triggering of discharging means by contact of injector with patient body
• CPC Class Codes: A61M 2005/2073 preventing premature release, e.g. by making use of a safety lock
• CPC Class Codes: A61M 5/1782 Devices aiding filling of syringes in situ combination of a vial and a syringe for transferring or mixing their contents A61J1/2096, filling of medical containers in general B65B3/003
• CPC Class Codes: A61M 5/2033 Spring-loaded one-shot injectors with or without automatic needle insertion multishot dosing syringes A61M5/31525, needle insertion only A61M5/3287
• CPC Class Codes: A61M 5/2066 comprising means for injection of two or more media, e.g. by mixing
• CPC Class Codes: A61M 5/30 Syringes for injection by jet action, without needle, e.g. for use with replaceable ampoules or carpules

Abstract

A disposable injector (4) having a two-chamber system (99), wherein at least one first chamber (105) is part of a piston-cylinder unit (100) that can be accommodated in the disposable injector (4), and wherein the second chamber (255) is part of a chamber (250) which is at least temporarily closed by means of a stopper (257) and inserted into a container adapter (200) detachably mounted on the disposable injector (4), or part of a piston-cylinder unit (254), and wherein the container adapter (200) comprises a connecting tube (242) initially closed by means of a cap (290). To this end, on the side oriented toward the second chamber, the stopper has a recess (271), into which at least one stopper channel (275) connecting the lateral surface (277) of the stopper to the recess (271) opens. After the container has been pushed in or activated, the connecting tube (242) connects the interior of the piston-cylinder unit to the interior of the container or of the piston-cylinder unit via the stopper channel and the tubular channel.

Claims

1. In combination with a device, comprising

a disposable injector (4) having a sterile and gastight cylinder-piston unit (100), which has a first chamber (105),

a container adapter (200) mounted on the disposable injector (4), and

a container (250) releasably fitted on the container adapter (200) and having a second chamber (255), or a cylinder-piston unit (254) with a second chamber (255), the cylinder-piston unit (254) releasably fitted on the container adapter (200), the second chamber (255) is at least temporarily closed in a sterile and gastight manner by means of a stopper (257), the container adapter (200) comprises a connecting tube (242) having a lateral surface (247), the connecting tube (242) having a longitudinal bore (244) initially closed by means of a cap (290) and having at least one tubular channel (245) connecting the longitudinal bore (244) to the lateral surface (247), the improvement which comprises:

the cap (290) includes a detachable cap base (294), the cap base (294) is initially surrounded on its inner side by a groove (293);

the stopper (257) having a lateral surface (277), the stopper (257) at the top thereof has on its underside oriented toward the second chamber (255) a central recess (271), the stopper at the top thereof includes a recess base (274) that initially lies above and aligned with the central recess (271), the recess base (274) is initially bounded on the upper side of the top of the stopper (257) by a surrounding annular groove (273), the stopper (257) below the top thereof has therein at least one stopper channel (275) connecting the lateral surface (277) of the stopper (257) to the central recess (271), the at least one stopper channel (275) having a channel base (278) nearest the top of the stopper (257),

the central recess (271) is sized to receive and to hold the cap base (294) and recess base (274), both the cap base (294) and the recess base (274) are moved within the central recess (271) by means of the connecting tube (242) when the container (250) or the cylinder-piston unit (254) is pushed in or activated and the cap base (294) and the recess base (274) are held by the stopper (257) in predetermined position after activation,

after the container (250) has been pushed in or activated, the connecting tube (242) connects the interior (110) of the cylinder-piston unit (100) to the interior (252) of the container (250) or the cylinder-piston unit (254) by way of the at least one stopper channel (275) and the tubular channel (245).

2. The device as claimed in claim 1, wherein firstly one chamber (105;

255) is at least partially filled with an active substance (2) and the other chamber respectively (255;

105) is at least partially filled with a solvent (1).

3. The device as claimed in claim 1, wherein the distance of the channel base (278) from the container (250) or cylinder piston unit (254) side end face of the stopper (257) is greater than the sums of the lengths of the cap base (294) and the recess base (274) as well as the diameter or the depth of the tubular channel (245).

4. The device as claimed in claim 1, wherein the cross section of the recess base (274) corresponds to the cross section of the recess (271).

5. The device as claimed in claim 4, wherein the cross section of the cap base (294) is smaller than the cross section of the recess base (274).

6. The device as claimed in claim 1, wherein the tubular channel (245) is at least approximately radially oriented.

7. The device as claimed in claim 1, wherein the tubular channel (245) is arranged at the end face of the connecting tube (242).

8. The device as claimed in claim 1, wherein the lateral surface (247) of the connecting tube (242) has a circumferential annular groove (248).

9. The device as claimed in claim 1, wherein the cap (290) has an elastically deformable wall area (291) surrounding the detachable cap base (294).

10. The device as claimed in claim 1, when the container (250) or the cylinder-piston unit (254) is pushed in or activated the connecting tube (242) sits in a sealing manner in the recess (271).

11. The device as claimed in claim 1, wherein the channel base (278) is rounded in the form of a half shell.

12. The device as claimed in claim 1, wherein the lateral surface (277) of the stopper (257) has a plurality of stages (279) each tapering frustoconically from the top to the bottom.

13. The device as claimed in claim 1, when the container (250) or the cylinder-piston unit (254) is pushed in or activated the recess base (274) is frictionally engaged with the central recess (271).

14. The device as claimed in claim 13, when the container (250) or the cylinder-piston unit (254) is pushed in or activated the cap base (294) is frictionally engaged with the central recess (271).