LINEARLY ACTUATED DISPENSER AND THERAPEUTIC PACKAGE SUITABLE FOR ADMINISTERING A THERAPEUTIC SUBSTANCE AND RELATED METHOD

• US 20110270220A1
• Filed: 03/03/2011
• Published: 11/03/2011
• Est. Priority Date: 03/03/2010
• Status: Abandoned Application

• Current Assignee: Aktivpak, Inc.
• Original Assignee: Aktivpak, Inc.
• Inventors: Genosar, Amir
• Application Number:
  US13/040,134
• Publication Number:
  US 20110270220A1
• Time in Patent Office: Days
• US Class Current: 604/506
• CPC Class Codes: A61J 1/067 Flexible ampoules, the contents of which are expelled by squeezing
• CPC Class Codes: A61J 1/2024 having peelable seals
• CPC Class Codes: A61J 1/2093 Containers having several compartments for products to be mixed
• CPC Class Codes: A61M 5/2425 by compression of deformable ampoule or carpule wall
• CPC Class Codes: A61M 5/2448 comprising means for injection of two or more media, e.g. by mixing
• CPC Class Codes: B65D 81/3261 Flexible containers having several compartments

Abstract

A device for administering a therapeutic substance includes a sealed package and an administration assembly. The sealed package includes a collapsible compartment containing the substance. The administration assembly includes a dispenser that is in fluid communication with the substance. At least one compression member is movable by linear actuation to progressively collapse the collapsible compartment and urge the therapeutic substance through the dispenser.

Claims

1. A device for administering a therapeutic substance, comprising:

a sealed package including a collapsible compartment containing the therapeutic substance; and

an administration assembly comprising;

a dispenser in fluid communication with the therapeutic substance; and

at least one compression member movable by linear actuation to progressively collapse the collapsible compartment and urge the therapeutic substance through the dispenser.

2. The device of claim 1, wherein the sealed package includes at least first and second collapsible compartments, and the at least one compression member progressively collapses at least one of the first and second collapsible compartments to combine the therapeutic substances of the first and second collapsible compartments.

3. The device of claim 1, wherein the dispenser comprises a needle.

4. The device of claim 1, wherein the at least one compression member is movable by linear actuator in a first direction to collapse the collapsible compartment, and movable by linear actuation in a second direction to urge the therapeutic substance through the dispenser.

5. The device of claim 1, wherein the at least one compression member changes direction of motion between progressively collapsing the collapsible compartment and urging the therapeutic substance through the dispenser.

6. A single use dispenser for hypodermic administration of a unit dose of a therapeutic fluid to a subject, comprising:

a hermetically sealed package comprising;

a collapsible first compartment containing a first therapeutic substance and comprising a first flexible wall;

a collapsible second compartment containing a second therapeutic substance and comprising a second flexible wall;

a frangible seal disposed between the collapsible first and second compartments;

an administration assembly comprising;

a dispenser positionable in fluid communication with at least one of the collapsible first and second compartments;

a compression member operable to rupture the frangible seal to permit the first and second therapeutic substances to merge and be dispensed.

7. The single use dispenser of claim 6, further comprising a rigid backing supporting the hermetically sealed package.

8. The single use dispenser of claim 6, wherein operation of the administration assembly moves the dispenser between extended and retracted positions.

9. The single use dispenser of claim 6, wherein the administration assembly includes an actuator linearly operable to move the compression member to force the merged first and second therapeutic substances through the dispenser.

10. The single use dispenser of claim 6, wherein the compression member comprises a roller.

11. The single use dispenser of claim 6, wherein the compression member is movable in opposite directions to first rupture the frangible seal and then force the first and second therapeutic substances through the dispenser.

12. The single use dispenser of claim 6, wherein the dispenser comprises an elongate needle.

13. The single use dispenser of claim 12, wherein the elongate needle extends in a direction perpendicular to a direction of movement of the compression member.

14. A therapeutic package for use in administering a dose of a therapeutic substance, comprising:

first and second sealed compartments mounted to a planar surface of a backing member and being pre-filled with first and second therapeutic substances, respectively;

a frangible seal disposed between the first and second sealed compartments;

a compression member operable to apply a first force to at least one of the first and second sealed compartments in a first direction in a plane parallel with the planar surface of the backing member to rupture the frangible seal and combine the first and second therapeutic substances to form a merged substance, and operable to apply a second force in a second direction opposite the first direction to force the merged substance out of the therapeutic package.

15. The therapeutic package of claim 14, wherein the first sealed compartment has a greater volume than the second sealed compartment.

16. The therapeutic package of claim 14, further comprising a housing and an actuator, the first and second sealed compartments being retained in the housing, and the compression member being coupled to the actuator, wherein advancing and retracting the actuator relative to the housing applies the first and second forces.

17. The therapeutic package of claim 14, wherein the compression member is coupled to a lever, and pivotal movement of the lever moves the compression member to apply the first and second forces.

18. The therapeutic package of claim 14, wherein the compression member comprises a planar portion arranged to contact at least one of the first and second sealed compartments to apply at least one of the first and second forces.

19. A method of administering a dose of a therapeutic substance, comprising:

providing a dispensing device having an administration assembly and a sealed package;

operating a portion of the administration assembly linearly to apply a first force to at least one sealed portion of the sealed package to activate a therapeutic substance contained therein;

operating the portion of the administration assembly linearly to apply a second force to the sealed package to dispense the therapeutic substance from the dispensing device.

20. The method of claim 19, wherein the administration assembly comprises a housing, a compression member, and an actuator, and operating the actuator linearly relative to the housing applies the first and second forces with the compression member.

21. The method of claim 20, wherein the administration assembly comprises a needle and an actuator, the method further comprising moving the needle out of the housing with operation of the actuator.

22. The method of claim 19, wherein applying the first force occurs in a first direction, and applying the second force occurs in a direction opposite the first direction.

23. A method of dispensing a substance to a subject, comprising:

providing a dispensing device having a compression member, a housing, and a sealed package, the sealed package including first and second sealed compartments that include different substances;

situating the dispensing device proximate an application region on the subject;

moving the compression member relative to the housing to apply a compression force to at least one of the first and second sealed compartments to combine the substances of the first and second sealed compartments and form a merged substance;

compressing at least one of the first and second sealed compartments to dispense the merged substance to the subject at the application region.

24. The method of claim 23, wherein the dispensing device includes an actuator coupled to the compression member, and compressing to dispense the merged substance includes moving the actuator linearly to apply a compression force to at least one of the first and second sealed compartments.

25. The method of claim 23, wherein the dispensing device includes an actuator coupled to the compression member and movable relative to the housing, the method including moving the actuator linearly relative to the housing to move the compression member relative to the housing to apply the compression force.

26. The method of claim 23, wherein the dispensing device includes an actuator coupled to the compression member and movable relative to the housing, the method including pivoting the actuator relative to the housing to move the compression member relative to the sealed package.

27. A dispensing device, comprising:

a sealed package comprising;

at least one compartment containing a substance;

a backing having at least one compression surface with a first surface shape when in a rest position; and

a compression panel for compressing the at least one compartment between the backing and the compression panel, the compression panel having at least one compression surface with a second surface shape when in a rest position that is different than the first surface shape;

wherein at least one of the first and second surface shapes is deformable to substantially accept a shape of the other during compression of the at least one compartment.

28. The dispensing device of claim 27, further comprising an actuator configured to cause dispensing of the substance from the dispensing device, wherein a position of the actuator before operation of the dispensing device and after dispensing the substance is substantially the same.

29. The dispensing device of claim 28, wherein the actuator causes mixing of at least two substances prior to dispensing.

30. A medical syringe for injecting a dose to a subject, comprising:

a dispensing assembly supporting a Luer lock connector that is configured to receive a needle, the Luer lock being retractable upon completion of injection of the dose to draw at least a portion of the needle into the medical syringe.

31. The medical syringe of claim 30, wherein the medical syringe further includes a sealed package that contains the dose.

32. The medical syringe of claim 30, wherein the dispensing assembly includes an actuator and a compression member, and linear operation of the actuator causes the compression member to inject the dose.

33. A sealed package, comprising:

a backing comprising an extension accommodating an dispensing feature;

at least one compartment mounted to the backing and containing at least one substance.

34. The sealed package of claim 33, wherein the backing includes a first surface upon which the at least one compartment is mounted, and the extension extends perpendicular to the first surface.

35. The sealed package of claim 33, further comprising a channel disposed on the backing and providing fluid communication between the at least one compartment and an administration feature.

36. The sealed package of claim 35, wherein a frangible seal is disposed along the channel to temporarily prevent fluid communication between the at least one compartment and the administration feature.

37. The sealed package of claim 33, wherein the dispensing feature is at least one of a needle, a mini needle, a micro-needle, a connector, a male Luer connector, a female Luer connector, a topical applicator, a spray nozzle, an ophthalmic applicator, an ear dispenser, a fitting, or a tube.

39. The dispensing device of claim 35, wherein the compression member has a panel construction.

40. The dispensing device of claim 35, wherein the sealed package includes first and second compartments containing first and second substances, respectively, the first frangible seal is defined between the first and second compartments, and rupturing the first frangible seal permits merging of the first and second substances.

38. A dispensing device, comprising:

a compression member; and

a sealed package comprising a first frangible seal and a second frangible seal that at least partially define a perimeter of a first compartment;

wherein moving the compression member in a first direction ruptures the first frangible seal, and moving the compression member in a second direction ruptures the second frangible seal.