N-Acylthiourea and N-Acylurea Inhibitors of the Hedgehog Protein Signalling Pathway
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Abstract
The present invention relates to the use of acylthiourea or acylurea derivatives for the treatment of pathologies involving a tissue dysfunction associated with a deregulation of the Hedgehog protein signalling pathway, and also to novel acylthiourea or acylurea derivatives as such, to their use as a medicinal product, and to pharmaceutical compositions containing them.
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20 Claims
- 1. The use of compounds with the following formula (I):
- 2. The use of compounds with the following formula (I):
- 8. Compounds with the following formula (I′
- 16. A method for the treatment of tumors associated with a hyperactivation of the Hedgehog protein signaling pathway or of neuro-degenerative type pathologies, comprising the step of administering compounds with the following formula (I):
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17. A method for the treatment of tumors associated with a hyperactivation of the Hedgehog protein signaling pathway or of neuro-degenerative type pathologies, comprising the step of administering compounds with the following formula (I):
Specification