NON-REACTIVE, HYDROPHILIC POLYMERS HAVING TERMINAL SILOXANES AND METHODS FOR MAKING AND USING THE SAME
First Claim
1. A composition comprising at least one stable, near-monodisperse, non-reactive hydrophilic polymer comprising in said polymer'"'"'s backbone, a hydrophilic segment having a degree of polymerization of about 300 to about 10,000, and a linear silicone segment on at least one terminal end of said non-reactive hydrophilic polymer, wherein said silicone segment comprises between about 6 and about 200 siloxy units, and said non-reactive hydrophilic polymer is associated, via the linear silicone block with a silicone hydrogel.
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Abstract
The present invention relates to compositions comprising at least one stable, near-monodisperse, non-reactive hydrophilic polymer comprising in said polymer'"'"'s backbone, a hydrophilic segment having a degree of polymerization of about 10 to about 1000, and a linear silicone segment at least one terminal end of said non-reactive hydrophilic polymer, wherein said silicone segment comprises between about 6 and about 200 siloxy units, and said non-reactive hydrophilic polymer is associated, via the linear silicone block with a silicone hydrogel. The non-reactive hydrophilic polymers may be incorporated into the formulation from which the silicone hydrogel is made or may be contacted with the silicone hydrogel post formation.
75 Citations
45 Claims
- 1. A composition comprising at least one stable, near-monodisperse, non-reactive hydrophilic polymer comprising in said polymer'"'"'s backbone, a hydrophilic segment having a degree of polymerization of about 300 to about 10,000, and a linear silicone segment on at least one terminal end of said non-reactive hydrophilic polymer, wherein said silicone segment comprises between about 6 and about 200 siloxy units, and said non-reactive hydrophilic polymer is associated, via the linear silicone block with a silicone hydrogel.
- 15. A process comprising contacting a silicone-containing contact lens with solution comprising contact angle lowering effective amount of at least one stable, near-monodisperse, non-reactive hydrophilic polymer comprising in said polymer'"'"'s backbone, a hydrophilic segment having a degree of polymerization of about 300 to about 10,000, and a linear silicone segment on at least one terminal end of said non-reactive hydrophilic polymer, wherein said silicone segment comprises between about 6 and about 200 siloxy units, under contacting conditions suitable to associate said non-reactive hydrophilic polymer with said silicone-containing contact lens.
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21. A process comprising
(a) Forming a reactive mixture comprising at least one silicone containing component, at least and at least one stable, near-monodisperse, non-reactive hydrophilic polymer comprising in said polymer'"'"'s backbone, a hydrophilic segment having a degree of polymerization of about 300 to about 10,000, and a linear silicone segment on at least one terminal end of said non-reactive hydrophilic polymer, wherein said silicone segment comprises between about 6 and about 200 siloxy units, and (b) Curing said reactive mixture to form a contact lens.
- 26. An ophthalmic device comprising a silicone-containing polymer and at least one stable, non-reactive hydrophilic polymer comprising in said non-reactive hydrophilic polymer'"'"'s backbone, a hydrophilic segment having a degree of polymerization of about 300 to about 10,000, and a linear silicone segment on at least one terminal end of said non-reactive hydrophilic polymer, wherein said silicone segment comprises between about 6 and about 200 siloxy units, wherein said non-reactive hydrophilic polymer is associated, via the linear silicone block, with said silicone-containing polymer and provides said ophthalmic device with a reduction in lipid uptake compared to the silicone-containing polymer of at least about 20%.
- 35. An ophthalmic solution comprising at least one stable, non-reactive hydrophilic polymer comprising in said polymer'"'"'s backbone, a hydrophilic segment having a degree of polymerization of about 300 to about 10,000, and a linear silicone segment at least one terminal end of said non-reactive hydrophilic polymer, wherein said silicone segment comprises between about 6 and about 200 siloxy units, wherein said non-reactive hydrophilic polymer is present in a contact angle reducing amount and said ophthalmic solution is transparent.
Specification