OXYGEN ENHANCING MEMBRANE SYSTEMS FOR IMPLANTABLE DEVICES
First Claim
1. An implantable device for continuous in vivo measurement of an analyte concentration in a host, the implantable device comprising:
- a sensor configured to operatively connect with electronic circuitry, wherein the electronic circuitry is configured to generate a signal indicative of a concentration of an analyte in a host; and
a membrane located over the sensor, wherein the membrane has a thickness of from about 3 microns to about 100 microns, wherein the membrane has an oxygen permeability of from about 3 Barrers to about 1000 Barrers, and wherein the membrane has an oxygen solubility that is at least about three times greater than an oxygen solubility of water.
2 Assignments
0 Petitions
Accused Products
Abstract
The present invention relates generally to systems and methods for increasing oxygen availability to implantable devices. The preferred embodiments provide a membrane system configured to provide protection of the device from the biological environment and/or a catalyst for enabling an enzymatic reaction, wherein the membrane system includes a polymer formed from a high oxygen soluble material. The high oxygen soluble polymer material is disposed adjacent to an oxygen-utilizing source on the implantable device so as to dynamically retain high oxygen availability to the oxygen-utilizing source during oxygen deficits. Membrane systems of the preferred embodiments are useful for implantable devices with oxygen-utilizing sources and/or that function in low oxygen environments, such as enzyme-based electrochemical sensors and cell transplantation devices.
164 Citations
20 Claims
-
1. An implantable device for continuous in vivo measurement of an analyte concentration in a host, the implantable device comprising:
-
a sensor configured to operatively connect with electronic circuitry, wherein the electronic circuitry is configured to generate a signal indicative of a concentration of an analyte in a host; and a membrane located over the sensor, wherein the membrane has a thickness of from about 3 microns to about 100 microns, wherein the membrane has an oxygen permeability of from about 3 Barrers to about 1000 Barrers, and wherein the membrane has an oxygen solubility that is at least about three times greater than an oxygen solubility of water. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10)
-
-
11. An implantable device for continuous in vivo measurement of an analyte concentration in a host, the implantable device comprising:
-
a sensor configured to operatively connect with electronic circuitry, wherein the electronic circuitry is configured to generate a signal indicative of a concentration of an analyte in a host; and a membrane located over the sensor, the membrane comprising; a first domain comprising an enzyme configured to react with the analyte, wherein the first domain further comprises a material having an oxygen solubility at least about three times greater than an oxygen solubility of water; and a second domain configured to control a flux therethrough of an analyte to the first domain, wherein the second domain comprises a material having an oxygen permeability of from about 3 Barrers to about 1000 Barrers. - View Dependent Claims (12, 13, 14, 15, 16, 17, 18, 19, 20)
-
Specification