IMPLANTABLE-GLUCOSE RESPONSIVE INSULIN DELIVERY DEVICE
First Claim
1. A biocompatible insulin delivery device comprising an insulin reservoir sealed with a glucose-responsive plug, wherein the plug functions to release insulin from the reservoir in response to a hyperglycemic glucose concentration and to prevent insulin release from the reservoir in response to hypoglycemic glucose concentration and wherein the plug incorporates an inorganic component.
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Accused Products
Abstract
A biocompatible insulin delivery device is provided comprising an insulin reservoir sealed with a glucose-responsive plug or membrane. The plug functions to release insulin from the reservoir in response to a hyperglycemic glucose concentration and to prevent insulin release from the reservoir in response to hypoglycemic glucose concentration. In one embodiment, the plug is made of a biocompatible polymeric matrix comprising an inorganic component, a stimulus-responsive component and a catalytic component.
6 Citations
20 Claims
- 1. A biocompatible insulin delivery device comprising an insulin reservoir sealed with a glucose-responsive plug, wherein the plug functions to release insulin from the reservoir in response to a hyperglycemic glucose concentration and to prevent insulin release from the reservoir in response to hypoglycemic glucose concentration and wherein the plug incorporates an inorganic component.
- 18. A biocompatible glucose responsive membrane comprises a polymeric matrix having an inorganic component and a stimuli-responsive component adapted to alter the porosity of the matrix in response to a change in glucose concentration.
Specification