POROGEN COMPOSITIONS, METHOD OF MAKING AND USES
First Claim
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1. A porogen composition comprising:
- a) a shell material; and
b) a core material;
wherein the shell material has a melting temperature that is lower than a melting temperature of the core material.
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Abstract
The present specification discloses porogen compositions comprising a core material and shell material, methods of making such porogen compositions, methods of forming such porous materials using such porogen compositions, biocompatible implantable devices comprising such porous materials, and methods of making such biocompatible implantable devices.
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Citations
23 Claims
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1. A porogen composition comprising:
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a) a shell material; and b) a core material; wherein the shell material has a melting temperature that is lower than a melting temperature of the core material. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8)
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9. A porogen composition comprising:
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a) a shell material; and b) a core material; wherein under a given physical or physicochemical treatment the shell material is fusible and the core material is non-fusible. - View Dependent Claims (10, 11, 12, 13, 14, 15, 16, 17, 18)
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19. A method of making a porogen composition comprising the steps of:
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a) forming a particle out of a core material; and b) coating the particle with a shell material; wherein the porogen composition comprises a shell material and a core material, wherein the shell material has a melting temperature that is lower than a melting temperature of the core material.
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20. A method for m a porous material, the method comprising the steps of:
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a) coating porogens with a substance to form a substance coated porogen mixture, the porogens comprise a shell material and a core material, wherein the shell material has a melting temperature that is lower than a melting temperature of the core material; b) treating the substance coated porogen mixture to form a porogen scaffold comprising fused porogens and stabilized the material; and c) removing the porogen scaffold, wherein porogen scaffold removal results in a porous material, the porous material comprising a matrix defining an array of interconnected pores.
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21. A method for making biocompatible implantable device comprising the step of:
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a) coating a mandrel with an elastomer base; b) curing the elastomer base to form a base layer; c) coating the cured base layer with an elastomer base; d) coating the elastomer base with porogens to form an elastomer coated porogen mixture, the porogens comprise a shell material and a core material, wherein the shell material has a melting temperature that is lower than a melting temperature of the core material; e) treating the elastomer coated porogen mixture to form a porogen scaffold comprising fused porogens and cure the elastomer base, wherein the porogen scaffold comprises a three-dimensional structure where substantially all the fused porogens are each connected to at least four other fused porogens, and wherein the diameter of substantially all the connections between each fused porogen in between about 15% to about 80% of the mean porogen diameter; and f) removing the porogen scaffold, wherein porogen scaffold removal results in a porous material, the porous material comprising a non-degradable, biocompatible, elastomer matrix defining an array of interconnected pores. - View Dependent Claims (22, 23)
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Specification