POROGEN COMPOSITIONS, METHOD OF MAKING AND USES

• US 20110278755A1
• Filed: 05/10/2011
• Published: 11/17/2011
• Est. Priority Date: 05/11/2010
• Status: Active Grant

• Current Assignee: Allergan Incorporated (Abbvie Incorporated)
• Original Assignee: Allergan Incorporated (Abbvie Incorporated)
• Inventors: Chan, Athene W., Liu, Futian, Manesis, Nicholas J., Yu, Xiaojie
• Granted Patent: US 8,685,296 B2
• Time in Patent Office: Days
• US Class Current: 264/41
• CPC Class Codes: A61F 2/12 Mammary prostheses and implants
• CPC Class Codes: A61L 2430/04 for mammary reconstruction
• CPC Class Codes: A61L 27/16 obtained by reactions only involving carbon-to-carbon unsaturated bonds
• CPC Class Codes: A61L 27/18 obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
• CPC Class Codes: A61L 27/50 Materials characterised by their function or physical properties , e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
• CPC Class Codes: A61L 27/56 Porous materials, e.g. foams or sponges
• CPC Class Codes: A61L 27/58 Materials at least partially resorbable by the body
• CPC Class Codes: A61L 31/10 Macromolecular materials
• CPC Class Codes: C08L 23/22 Copolymers of isobutene; Butyl rubber ; Homo- or copolymers of other iso-olefins
• CPC Class Codes: C08L 53/02 of vinyl-aromatic monomers and conjugated dienes
• CPC Class Codes: C08L 83/04 Polysiloxanes
• CPC Class Codes: Y10T 428/2989 Microcapsule with solid core [includes liposome]

Abstract

The present specification discloses porogen compositions comprising a core material and shell material, methods of making such porogen compositions, methods of forming such porous materials using such porogen compositions, biocompatible implantable devices comprising such porous materials, and methods of making such biocompatible implantable devices.

Claims

1. A porogen composition comprising:

a) a shell material; and

b) a core material;

wherein the shell material has a melting temperature that is lower than a melting temperature of the core material.

2. The porogen composition of claim 1, wherein the shell material is a natural or synthetic material.

3. The porogen composition of claim 1, wherein the shell material is an inorganic or organic material.

4. The porogen composition of claim 2, wherein the shell material is a salt and its derivatives, a ceramic and/or its derivatives, a sugar and its derivatives, a polysaccharide and its derivatives, a wax and its derivatives, a metal and its derivatives, a surfactant and its derivatives, a water soluble solid and its derivatives, a polymer and its derivatives, composites thereof, or combinations thereof.

5. The porogen composition of claim 1, wherein the core material is a natural or synthetic material.

6. The porogen composition of claim 1, wherein the core material is an inorganic or organic material.

7. The porogen composition of claim 5, wherein the core material is a salt and its derivatives, a ceramic and/or its derivatives, a sugar and its derivatives, a polysaccharide and its derivatives, a wax and its derivatives, a metal and its derivatives, a water soluble solid and its derivatives, a polymer and its derivatives, composites thereof, or combinations thereof.

8. The porogen composition of claim 1, wherein the core material is a sugar and the shell material is a polymer.

9. A porogen composition comprising:

a) a shell material; and

b) a core material;

wherein under a given physical or physicochemical treatment the shell material is fusible and the core material is non-fusible.

10. The porogen composition of claim 9, wherein the shell fusion occurs by a physical state change from solid phase to liquid or rubbery phase.

11. The porogen composition of claim 9, wherein the physicochemical treatment is heat or an organic solvent.

12. The porogen composition of claim 9, wherein the shell material is a natural or synthetic material.

13. The porogen composition of claim 9, wherein the shell material is an inorganic or organic material.

14. The porogen composition of claim 12, wherein the shell material is a salt and its derivatives, a ceramic and/or its derivatives, a sugar and its derivatives, a polysaccharide and its derivatives, a wax and its derivatives, a metal and its derivatives, a surfactant and its derivatives, a water soluble solid and its derivatives, a polymer and its derivatives, composites thereof, or combinations thereof.

15. The porogen composition of claim 9, wherein the core material is a natural or synthetic material.

16. The porogen composition of claim 9, wherein the core material is an inorganic or organic material.

17. The porogen composition of claim 15, wherein the core material is a salt and its derivatives, a ceramic and/or its derivatives, a sugar and its derivatives, a polysaccharide and its derivatives, a wax and its derivatives, a metal and its derivatives, a water soluble solid and its derivatives, a polymer and its derivatives, composites thereof, or combinations thereof.

18. The porogen composition of claim 9, wherein the core material is a sugar and the shell material is a polymer.

19. A method of making a porogen composition comprising the steps of:

a) forming a particle out of a core material; and

b) coating the particle with a shell material;

wherein the porogen composition comprises a shell material and a core material, wherein the shell material has a melting temperature that is lower than a melting temperature of the core material.

20. A method for m a porous material, the method comprising the steps of:

a) coating porogens with a substance to form a substance coated porogen mixture, the porogens comprise a shell material and a core material, wherein the shell material has a melting temperature that is lower than a melting temperature of the core material;

b) treating the substance coated porogen mixture to form a porogen scaffold comprising fused porogens and stabilized the material; and

c) removing the porogen scaffold, wherein porogen scaffold removal results in a porous material, the porous material comprising a matrix defining an array of interconnected pores.

21. A method for making biocompatible implantable device comprising the step of:

a) coating a mandrel with an elastomer base;

b) curing the elastomer base to form a base layer;

c) coating the cured base layer with an elastomer base;

d) coating the elastomer base with porogens to form an elastomer coated porogen mixture, the porogens comprise a shell material and a core material, wherein the shell material has a melting temperature that is lower than a melting temperature of the core material;

e) treating the elastomer coated porogen mixture to form a porogen scaffold comprising fused porogens and cure the elastomer base, wherein the porogen scaffold comprises a three-dimensional structure where substantially all the fused porogens are each connected to at least four other fused porogens, and wherein the diameter of substantially all the connections between each fused porogen in between about 15% to about 80% of the mean porogen diameter; and

f) removing the porogen scaffold, wherein porogen scaffold removal results in a porous material, the porous material comprising a non-degradable, biocompatible, elastomer matrix defining an array of interconnected pores.

22. The method of claim 21, wherein steps (b) and (c) are repeated at least once.

23. The method of claim 21, wherein steps (b) and (c) are repeated at least repeated twice.