COMPOSITIONS AND METHODS FOR TREATING OBESITY AND RELATED DISORDERS BY CHARACTERIZING AND RESTORING MAMMALIAN BACTERIAL MICROBIOTA
First Claim
1. A method of treating a disease in a mammal comprising administering to the mammal a therapeutically effective amount of a probiotic composition comprising one or more bacterial strains, wherein the composition (i) stimulates growth or activity of one or more bacterial taxa which are under-represented in microbiota of the mammal as compared to a healthy control or (ii) inhibits growth or activity of one or more bacterial taxa which are over-represented in microbiota of the mammal as compared to a healthy control.
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Abstract
The present invention relates to characterizing changes in mammalian gastrointestinal microbiota associated with antibiotic treatment and various disease conditions (such as obesity, metabolic syndrome, insulin-deficiency or insulin-resistance related disorders, glucose intolerance, diabetes, non-alcoholic fatty liver, abnormal lipid metabolism, short stature, osteoporosis, and other disorders of bone formation and mineralization, etc.) and related diagnostic and therapeutic methods. Therapeutic methods of the invention involve the use of probiotics, prebiotics, or narrow spectrum antibiotics/anti-bacterial agents that are capable of restoring healthy mammalian bacterial gastrointestinal microbiota.
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Citations
54 Claims
- 1. A method of treating a disease in a mammal comprising administering to the mammal a therapeutically effective amount of a probiotic composition comprising one or more bacterial strains, wherein the composition (i) stimulates growth or activity of one or more bacterial taxa which are under-represented in microbiota of the mammal as compared to a healthy control or (ii) inhibits growth or activity of one or more bacterial taxa which are over-represented in microbiota of the mammal as compared to a healthy control.
- 12. A method for treating a disease associated with antibiotic treatment in a mammal comprising (i) stimulating growth or activity of one or more bacterial taxa which have been depleted in microbiota of the mammal as a result of antibiotic treatment of the mammal or (ii) inhibiting growth or activity of one or more bacterial taxa which are over-represented in microbiota of the mammal as a result of antibiotic treatment of the mammal.
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22. A method for restoring at least one bacterial taxa depleted as a result of antibiotic treatment or disease in a mammal comprising:
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a) identifying under-represented bacterial taxa in an antibiotic-treated or diseased microbiota sample from the mammal as compared to a healthy control; b) culturing the identified under-represented bacteria from step a); and c) administering the bacterial inoculant(s) from step b) to the mammal, wherein the inoculant(s) increases growth of the under-represented bacteria in the mammal. - View Dependent Claims (23, 24, 25, 26, 27, 28, 29, 30, 31, 32)
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- 33. A method of treating a disease in a mammal, wherein said disease is associated with a change in microbiota of the mammal as compared to a healthy control, comprising administering to the mammal a therapeutically effective amount of a narrow spectrum antibiotic or another anti-bacterial agent to inhibit growth or activity of one or more bacterial taxa which are over-represented in the microbiota of the mammal as compared to the healthy control.
- 43. A method for increasing adult height or muscle mass in a mammal in need thereof comprising administering to the mammal a sub-therapeutic concentration of an antibiotic early in life.
- 45. A method for increasing adult height or muscle mass in a mammal in need thereof comprising (i) stimulating growth or activity of one or more bacterial taxa which is over-represented in microbiota of the mammal as a result of treatment with a sub-therapeutic concentration of an antibiotic early in life or (ii) inhibiting growth or activity of one or more bacterial taxa which is depleted in microbiota of the mammal as a result of treatment with a sub-therapeutic concentration of an antibiotic early in life.
Specification