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MODIFIED TYPE A DNA POLYMERASES

  • US 20110281305A1
  • Filed: 11/03/2009
  • Published: 11/17/2011
  • Est. Priority Date: 11/03/2008
  • Status: Active Grant
First Claim
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1. A modified Taq DNA polymerase showing at least 70% amino acid sequence identity with wild type Taq DNA polymerase (SEQ ID NO:

  • 1) and differing from Taq DNA polymerase in that its amino acid sequence comprises one or more amino acid alterations at one or more positions corresponding to P6, K53, K56, E57, K171, T203, E209, D238, L294, V310, G364, E400 A414, E507, 5515, E742, or E797 of Taq polymerase, relative to the corresponding wild-type enzyme Taq polymeras,wherein the one or more amino acid alterations increase enzyme activity, processivity, resistance to nucleic acid intercalating dyes, and/or salt-resistance.

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