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SELF-ASSEMBLED SINGLE MOLECULE ARRAYS AND USES THEREOF

  • US 20110281738A1
  • Filed: 05/02/2011
  • Published: 11/17/2011
  • Est. Priority Date: 10/07/2005
  • Status: Active Grant
First Claim
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1. A method of making a probe array, the method comprising the steps of:

  • providing a plurality of polynucleotide molecules attached to a surface of a support, wherein each polynucleotide molecule has a random coil state and comprises a concatemer of multiple copies of a probe sequence such that the polynucleotide molecule is attached to the surface within a region substantially equivalent to a projection of the random coil on the surface and randomly disposed at a density such that at least thirty percent of the polynucleotide molecules have a nearest neighbor distance of at least fifty nm; and

    identifying the probe sequence of each polynucleotide molecule on the surface to form the probe array.

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