METHOD FOR POSITIONING THE FOCUS OF A GRADIENT FIELD AND TREATMENT FACILITY

• US 20110282184A1
• Filed: 05/10/2011
• Published: 11/17/2011
• Est. Priority Date: 05/12/2010
• Status: Active Grant

• Current Assignee: Siemens Healthcare GMBH (Siemens AG)
• Original Assignee: Siemens AG
• Inventors: Maschke, Michael, Klingenbeck, Klaus
• Granted Patent: US 9,057,759 B2
• Time in Patent Office: Days
• US Class Current: 600/411
• CPC Class Codes: A61B 2034/2051 Electromagnetic tracking systems
• CPC Class Codes: A61B 2034/2063 Acoustic tracking systems, e.g. using ultrasound
• CPC Class Codes: A61B 2090/364 Correlation of different images or relation of image positions in respect to the body
• CPC Class Codes: A61B 2090/374 NMR or MRI
• CPC Class Codes: A61B 2090/376 using X-rays, e.g. fluoroscopy
• CPC Class Codes: A61B 34/73 Manipulators for magnetic surgery
• CPC Class Codes: A61B 5/055 involving electronic [EMR] or nuclear [NMR] magnetic resonance, e.g. magnetic resonance imaging
• CPC Class Codes: A61B 6/12 Arrangements for detecting or locating foreign bodies
• CPC Class Codes: A61B 6/4458 the source unit or the detector unit being attached to robotic arms
• CPC Class Codes: A61K 9/0009 involving or responsive to electricity, magnetism or acoustic waves; Galenical aspects of sonophoresis, iontophoresis, electroporation or electroosmosis microelectromechanical systems A61K9/0097
• CPC Class Codes: G01R 33/287 involving active visualization of interventional instruments, e.g. using active tracking RF coils or coils for intentionally creating magnetic field inhomogeneities
• CPC Class Codes: G01R 33/4812 MR combined with X-ray or computed tomography [CT]

Abstract

A method for guiding nanoparticles to a target location by a magnetic gradient field and/or holding them at the target location is proposed. The magnetic gradient field is generated by a magnet system with at least one magnet. A focus of the magnet system is registered with an X-ray device. At least one three-dimensional image dataset showing the target location is captured by the X-ray device. The position of the target location is determined manually and/or automatically in the image dataset or in an image dataset determined therefrom and is positioned automatically based on the registration of the focus so that the focus coincides with the position of the target location.

Claims

1-15. -15. (canceled)

16. A method for treating a target location with magnetic nanoparticles, comprising:

generating a magnetic gradient field by a magnet system comprising a magnet;

registering a focus of the magnet system with an X-ray device;

capturing a three-dimensional image dataset showing the target location by the X-ray device;

determining a position of the target location in the image dataset; and

automatically positioning the target location based on the registration so that a position of the focus coincides with the position of the target location.

17. The method as claimed in claim 16,

wherein an X-ray marker for marking the focus relative to the magnet is arranged on a support,

wherein the support is a lead ball attached to the magnet system,

wherein at least two X-ray images are captured by the X-ray device, and

wherein a three-dimensional position of the X-ray marker is determined from the two X-ray images.

18. The method as claimed in claim 16,

wherein the image dataset is fused with a previously captured three-dimensional dataset, and

wherein the previously captured three-dimensional dataset is a CT image dataset and/or a magnetic resonance image dataset and/or a PET image dataset.

19. The method as claimed in claim 18, wherein the previously captured three-dimensional dataset is captured by a magnetic resonance device that is at least partly registered with the X-ray device.

20. The method as claimed in claim 19,

wherein the X-ray device and the magnetic resonance device comprise same z-axis using a rail system,

wherein the registration is carried out with regard to other axes based on data of a sensor, and

wherein the sensor is an electromechanical and/or optical and/or magnetic sensor.

21. The method as claimed in claim 16, wherein the magnet system is attached to the X-ray device via an attachment device allowing a reproducible attachment.

22. The method as claimed in claim 16, wherein the magnet is an electromagnet for electrically displacing the focus relative to the target location.

23. The method as claimed in claim 16,

wherein a mechanical device of the magnet system is activated for mechanically displacing the focus relative to the target location and the mechanical device is an articulated-arm robot, and/or

wherein a mechanical device of a patient couch supporting a patient is activated for mechanically displacing the focus relative to the target location.

24. The method as claimed in claim 16,

wherein the nanoparticles are injected to the target location by a treatment catheter,

wherein the injection and/or positioning of the nanoparticles is monitored by a fluoroscopy image captured with the X-ray device,

wherein the fluoroscopy image or a monitoring dataset derived from the fluoroscopy image is displayed, and

wherein the display is overlaid with the image dataset or with a further image dataset derived from the image dataset.

25. The method as claimed in claim 16,

wherein a field strength of the magnetic gradient field is adapted automatically as a function of data determined from the image dataset, and

wherein the adaption is performed by changing a voltage and/or a current of an electromagnet of the magnet system.

26. The method as claimed in claim 16, wherein an electromagnetic adaptation coil is used for locally modifying field strength and/or direction of the gradient field.

27. The method as claimed in claim 16, wherein the X-ray device comprises an X-ray emitter and an X-ray detector attached to a or to an articulated-arm robot.

28. The method as claimed in claim 16, wherein a two-dimensional local image dataset or a three-dimensional local image dataset having a catheter introduced into a patient or arranged on the patient is captured and is fused with the image dataset.

29. The method as claimed in claim 28, wherein the catheter is an intravascular magnetic resonance imaging catheter.

30. The method as claimed in claim 28,

wherein the catheter comprises a position sensor,

wherein the position sensor is an electromagnetic position sensor and/or an ultrasound position sensor, and

wherein the image dataset is registered with the local image dataset based on data of the position sensor.

31. The method as claimed in claim 16, wherein the magnetic nanoparticles are guided to the target location by the magnetic gradient field and/or held at the target location.

32. The method as claimed in claim 16, wherein a further image dataset is determined from the captured image dataset and the position of the target location is determined in the further image dataset.

33. A treatment device for treating a target location with magnetic nanoparticles, comprising:

a magnet system having a magnet for generating a magnetic gradient field;

an X-ray device for capturing a three-dimensional image dataset showing the target location, the X-ray device comprising a C-arm with an X-ray emitter and an X-ray detector arranged opposite one another thereon; and

a control device for;

registering a focus of the magnet system with the X-ray device;

determining a position of the target location in the image dataset; and

automatically positioning the target location based on the registration so that a position of the focus coincides with the position of the target location.

34. The treatment device as claimed in claim 33, wherein the target location is a tumor.