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GENE ENCODING HUMAN GLUCOKINASE MUTANT, ENZYME ENCODED BY THE SAME, RECOMBINANT VECTORS AND HOSTS, PHARMACEUTICAL COMPOSITIONS AND USES THEREOF, METHODS FOR TREATING AND PREVENTING DISEASES

  • US 20110286984A1
  • Filed: 07/07/2011
  • Published: 11/24/2011
  • Est. Priority Date: 01/07/2009
  • Status: Active Grant
First Claim
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1. A human glucokinase mutant-encoding gene, characterized in that the gene comprises at least one of:

  • a nucleotide sequence as shown in SEQ ID NO;

    2; and

    a nucleotide sequence that is identical to the nucleotide sequence shown in SEQ ID NO;

    2 except the open reading frame (ORF) ranging from position 487 to 1884 of the nucleotide sequence shown in SEQ ID NO;

    2, the ORF encoding the same amino acid sequence as that encoded by the ORF of the nucleotide sequence shown in SEQ ID NO;

    2.

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