BIMATOPROST CRYSTALLINE FORM I
First Claim
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1. A pure bimatoprost, wherein said bimatoprost contains (by HPLC) not more than (NMT) 2% of sum of all related impurities and 1% of 5-trans isomer.
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Abstract
The invention provides a novel polymorphic form I of crystalline bimatoprost, method for preparation thereof and new crystalline intermediates in the preparation. This form I of crystalline bimatoprost is used in purification of crude bimatoprost and in storage of bimatoprost as active pharmaceutical intermediate. Use of the physical form of bimatoprost in the manufacture of a medicament is also disclosed.
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9 Claims
- 1. A pure bimatoprost, wherein said bimatoprost contains (by HPLC) not more than (NMT) 2% of sum of all related impurities and 1% of 5-trans isomer.
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9. Use of crystalline form I of bimatoprost for the preparation of pure bimatoprost.
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