Chlorhexidine-Containing Antimicrobial Laminates

• US 20110290259A1
• Filed: 01/07/2010
• Published: 12/01/2011
• Est. Priority Date: 01/07/2009
• Status: Active Grant

• Current Assignee: Entrotech, Inc.
• Original Assignee: Entrotech Life Sciences, Inc.
• Inventors: Foor, John S., McGuire, James E. Jr.
• Granted Patent: US 10,314,935 B2
• Time in Patent Office: Days
• US Class Current: 128/849
• CPC Class Codes: A61B 2017/00889 antimicrobial, disinfectant
• CPC Class Codes: A61B 2046/205 Adhesive drapes
• CPC Class Codes: A61B 46/40 Drape material, e.g. laminates; Manufacture thereof
• CPC Class Codes: A61F 2013/00604 Multilayer
• CPC Class Codes: A61F 2013/0091 with disinfecting or anaesthetics means, e.g. anti-mycrobic
• CPC Class Codes: A61L 15/46 Deodorants or malodour counteractants, e.g. to inhibit the formation of ammonia or bacteria
• CPC Class Codes: A61L 2300/206 Biguanides, e.g. chlorohexidine
• CPC Class Codes: A61L 2300/404 Biocides, antimicrobial agents, antiseptic agents

Abstract

Antimicrobial laminates of the invention comprise at least one adhesive layer; a backing outwardly exposed on a first side of the adhesive layer; and, optionally, a release liner outwardly exposed on a second side of the adhesive layer opposite from the first side of the adhesive layer. At least one of the at least one adhesive layer and the backing comprises an antimicrobially effective amount of substantially pure chlorhexidine.

Claims

1. An antimicrobial laminate comprising:

at least one adhesive layer;

a backing outwardly exposed on a first side of the adhesive layer; and

optionally, a release liner outwardly exposed on a second side of the adhesive layer opposite from the first side of the adhesive layer,

wherein at least one of the adhesive layer and the backing comprises an antimicrobially effective amount of substantially pure chlorhexidine.

2. The antimicrobial laminate of claim 1, wherein the laminate is a surgical incise drape.

3. The antimicrobial laminate of claim 1, wherein the laminate essentially comprises substantially transparent or translucent flexible polymeric materials.

4. The antimicrobial laminate of claim 1, wherein the backing has a thickness of about 14 microns or less.

5. The antimicrobial laminate of claim 1, wherein the backing has a thickness of about 6 microns or less.

6. The antimicrobial laminate of claim 1, wherein the backing, irrespective of any structural integrity provided by the at least one adhesive layer, imparts structural integrity to the laminate.

7. The antimicrobial laminate of claim 1, wherein the backing is extensible.

8. The antimicrobial laminate of claim 1, wherein the backing comprises a polyurethane base polymer.

9. The antimicrobial laminate of claim 1, wherein the at least one adhesive layer comprises a pressure-sensitive adhesive.

10. The antimicrobial laminate of claim 1, wherein the at least one adhesive layer comprises a skin-compatible adhesive.

11. The antimicrobial laminate of claim 1, wherein the at least one adhesive layer comprises a (meth)acrylate adhesive.

12. The antimicrobial laminate of claim 1, wherein the at least one adhesive layer has a thickness of about 5 microns to about 150 microns.

13. The antimicrobial laminate of claim 1, wherein the at least one adhesive layer has a thickness of about 30 microns to about 100 microns.

14. The antimicrobial laminate of claim 1, wherein the at least one adhesive layer has a thickness of about 10 microns to about 50 microns.

15. The antimicrobial laminate of claim 1, wherein the laminate is essentially free of chlorhexidine salt.

16. The antimicrobial laminate of claim 1, wherein the at least one adhesive layer is essentially free of antimicrobial agents.

17. The antimicrobial laminate of claim 1, wherein the backing is essentially free of antimicrobial agents.

18. The antimicrobial laminate of claim 1, wherein the at least one adhesive layer comprises the antimicrobially effective amount of substantially pure chlorhexidine.

19. The antimicrobial laminate of claim 1, wherein the at least one adhesive layer comprises at least about 3% by weight of the substantially pure chlorhexidine.

20. The antimicrobial laminate of claim 1, wherein the at least one adhesive layer comprises about 8.75% by weight of the substantially pure chlorhexidine.

21. The antimicrobial laminate of claim 1, wherein, when the laminate is tested against stainless steel according to ASTM D1000, the laminate has an adhesion level of at least about 350 mL/cm.

22. The antimicrobial laminate of claim 1, wherein, when the laminate is tested against stainless steel according to ASTM D1000, the laminate has an adhesion level of at least about 580 mL/cm.