HYDROGEL IMPLANTS WITH VARYING DEGREES OF CROSSLINKING
First Claim
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1. An implant comprising a hydrogel comprising:
- a first reactive precursor comprising a multi-arm polyether possessing electrophilic groups;
a second reactive precursor comprising nucleophilic groups; and
at least one initiated precursor comprising at least one vinyl group.
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Abstract
The present disclosure relates to a hydrogel composition and methods of using the same. The hydrogel composition may include precursors that react with each other upon contact as well as precursors that react upon contact with an initiator. In embodiments, the resulting hydrogels may have varying levels of crosslinking with both denser and less dense regions.
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Citations
31 Claims
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1. An implant comprising a hydrogel comprising:
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a first reactive precursor comprising a multi-arm polyether possessing electrophilic groups; a second reactive precursor comprising nucleophilic groups; and at least one initiated precursor comprising at least one vinyl group. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16)
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17. A composite hydrogel composition comprising:
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a first hydrogel comprising a first reactive precursor comprising a multi-arm polyether possessing electrophilic groups in combination with a second reactive precursor comprising nucleophilic groups; and a second hydrogel comprising at least one initiated precursor comprising at least one vinyl group, wherein the second hydrogel forms a barrier layer over at least a portion of the surface of the first hydrogel. - View Dependent Claims (18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31)
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Specification