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METHOD FOR THE SYNTHESIS OF PHOSPHORUS ATOM MODIFIED NUCLEIC ACIDS

  • US 20110294124A1
  • Filed: 12/02/2009
  • Published: 12/01/2011
  • Est. Priority Date: 12/02/2008
  • Status: Active Grant
First Claim
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1. A method for a synthesis of a nucleic acid comprising a chiral X-phosphonate moiety comprising reacting a molecule comprising an achiral H-phosphonate moiety and a nucleoside comprising a 5′

  • -OH moiety to form a condensed intermediate; and

    converting the condensed intermediate to the nucleic acid comprising a chiral X-phosphonate moiety.

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