METHOD FOR DETERMINING THE RISK OF PREECLAMPSIA USING PIGF-2 AND PIGF-3 MARKERS
First Claim
1. A method for determining the risk of a pregnant woman developing pre-eclampsia, comprising:
- i) determining selectively the level of one or more biochemical markers in a sample obtained from a pregnant woman, wherein at least one biochemical marker is a P1GF isoform selected from P1GF-2 and P1GF-3;
ii) comparing the level of the at least one biochemical marker in the sample with the level of the same biochemical marker in a control sample;
wherein a difference in the level of the at least one biochemical marker in the sample relative to the control sample is indicative of an increased risk of developing pre-eclampsia.
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Abstract
The present invention relates to a method for determining the risk of a pregnant woman developing pre-eclampsia. The method comprises i) determining the level of one or more biochemical markers in a sample obtained from a pregnant woman, and ii) comparing the level of the at least one biochemical marker in the sample with the level of the same biochemical marker in a control sample. A difference in the level of the biochemical marker in the sample relative to the control sample is indicative of an increased risk of developing pre-eclampsia. The isoform biochemical markers are preferably P1GF-2 and P1GF-3. The present invention relates also to a method for determining whether a pregnant woman has pre-eclampsia and as well as a kit for assessing the risk or presence of pre-eclampsia. In addition, the invention relates also to a computer program used in these determinations.
4 Citations
33 Claims
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1. A method for determining the risk of a pregnant woman developing pre-eclampsia, comprising:
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i) determining selectively the level of one or more biochemical markers in a sample obtained from a pregnant woman, wherein at least one biochemical marker is a P1GF isoform selected from P1GF-2 and P1GF-3; ii) comparing the level of the at least one biochemical marker in the sample with the level of the same biochemical marker in a control sample; wherein a difference in the level of the at least one biochemical marker in the sample relative to the control sample is indicative of an increased risk of developing pre-eclampsia. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13)
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14. A method for determining whether a pregnant woman has pre-eclampsia, comprising:
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i) determining selectively the level of one or more biochemical markers in a sample obtained from a pregnant woman, wherein at least one biochemical marker is a P1GF isoform selected from P1GF-2 and P1GF-3; ii) comparing the level of the at least one biochemical marker in the sample with the level of the same biochemical marker in a control sample; wherein a difference in the level of the at least one biochemical marker in the subject sample relative to the control sample is indicative of pre-eclampsia. - View Dependent Claims (15, 16, 17, 18)
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19. A computer program which when executed on a computer causes the computer to perform a process for determining risk or presence of pre-eclampsia in a pregnant woman, the process comprising:
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inputting a measurement of at least one biomarker obtained by; 1) assaying a sample obtained from the pregnant woman for one or more biochemical markers, wherein at least one biochemical marker is selected from PIGF-2 and PIGF-3; ii) comparing the level of the one or more biochemical marker in the sample with the level of the same biochemical marker in a control sample, wherein a difference in level of the one or more biochemical marker in the sample relative to the control sample is indicative of pre-eclampsia, and iii) determining a quantitative estimate of pre-eclampsia risk based on the result of the comparing. - View Dependent Claims (20, 21, 22, 23, 24, 25)
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26. A kit for assessing risk or presence of pre-eclampsia in a pregnant woman, comprising:
i) at least two detectable binding partners, wherein each detectable binding partner binds specifically to an individual P1GF isoform selected from PIGF-1, PIGF-2 and PIGF-3. - View Dependent Claims (27, 28, 29, 31)
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30. A kit for assessing risk and presence of pre-eclampsia in a pregnant woman, comprising:
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i) at least one antibody or an antigen-binding fragment thereof, that binds specifically to a P1GF isoform selected from PIGF-2 and PIGF-3; ii) instructions for using the antibody or antigen-binding fragment in the determination. - View Dependent Claims (32, 33)
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Specification