COMPOSITION FOR SKIN REGENERATION, CONTAINING A SECRETION IN THE CULTURE OF AN EMBRYONIC STEM CELL-DERIVED ENDOTHELIAL PROGENITOR CELL OR FRACTIONS THEREOF, AND USE THEREOF
First Claim
1. A composition for skin regeneration, comprising secretions from a culture of embryonic stem-cell derived endothelial progenitor cells or fractions thereof.
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Abstract
The present invention relates to a composition for skin regeneration, using a culture medium or a secretion in the culture of an embryonic stem cell-derived endothelial progenitor cell, and to the use thereof. As the present invention uses the secretion in the culture as a medicine and not the embryonic stem cell-derived endothelial progenitor cell itself, the risk of teratoma formation is prevented, and angiogenic activity is promoted to achieve improved effectiveness in healing wounds and burn wounds. The composition of the present invention, when used as a material in cosmetics, increases collagen synthesis and thus prevents skin aging. Particularly, the composition of the present invention in which the secretion in the culture is concentrated into a high concentration provides superior wound-healing effects as compared to a conventional human growth hormone (hGH).
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Citations
13 Claims
- 1. A composition for skin regeneration, comprising secretions from a culture of embryonic stem-cell derived endothelial progenitor cells or fractions thereof.
- 6. A composition for skin regeneration, comprising 1,250-1,250,000 pg/ml of epidermal growth factor (EGF), 35-35,000 pg/ml of (basic) fibroblast growth factor (FGF-2), 650-650,000 pg/ml of platelet-derived growth factor-AA (PDGF-AA), and 400-400,000 pg/ml of vascular endothelial growth factor (VEGF).
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11. A method for healing wounds, healing burn wounds, or skin cosmetics, comprising
(a) a step for culturing embryonic stem-cell derived endothelial progenitor cells; -
(b) a step for removing the endothelial progenitor cells and preparing the secretions from the culture or fractions thereof; and (c) a step for applying the culture secretions or fractions thereof to the skin of a mammal. - View Dependent Claims (12, 13)
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Specification